Studies on thyroid autoimmunity: anti-mouse TSH receptor immune response and central tolerance in mice
| Project/Area Number |
15K09437
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAGAYAMA Yuji 長崎大学, 原爆後障害医療研究所, 教授 (30274632)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 甲状腺 / 自己免疫 / バセドウ病 / TSH受容体 / マウスモデル |
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| Outline of Final Research Achievements |
Mice respond well to immunization with human thyrotropin receptor (TSHR), but not to immunization with mouse TSHR. We have previously found that peripheral immune tolerance plays a minor role in immune tolerance against mouse TSHR. The present studies was therefore designed to study a role for central tolerance in immune tolerance against mouse TSHR in BALB/c mice. By using deleton of thymic cells with anti-RANKL antibody and alos SKG mice which have a point mutation in ZAP-70 gene, we here clearly showed a significant role for central tolerance in immune tolerance against mouse TSHR in mice.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Long-term follow-up of a patient with sporadic non-autoimmune hyperthyroidism due to a thyrotropin receptor mutation (D619G).2018
Author(s)
Nishihara E, Tsugawa M, Ozaki Y, Nagayama Y, Fukata S, Hirokawa M, Ito M, Nishikawa M, Nakamura H, Ito Y, Miyauchi A.
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Journal Title
AACE Clin Case Rep.
Volume: 1
Related Report
Peer Reviewed / Open Access
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[Journal Article] Targeted Foxe1 overexpression in mouse thyroid causes the development of multinodular goiter but does not promote carcinogenesis.2016
Author(s)
Nikitski A, Saenko V, Shimamura M, Nakashima M, Matsuse M, Suzuki K, Rogounovitch T, Bogdanova T, Shibusawa N, Yamada M, Nagayama Y, Yamashita S, Mitsutake N
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Journal Title
Endocrinology
Volume: 印刷中
Issue: 5
Pages: 2182-2195
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency.2015
Author(s)
Guo C, Nakazawa Y, Woodbine L, Bjorkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS,Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T.
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Journal Title
J Allergy Clin Immunol.
Volume: 136 (4)
Issue: 4
Pages: 1007-1017
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Haploinsufficiency of interferon regulatory factor 4 strongly protects against autoimmune diabetes in non-obese diabetic mice.2015
Author(s)
Akazawa S, Kobayashi K, Kuriya G, Horie I, Yu L, Yamasaki H, Okita M, Nagayama Y, Matsuyama T, Akbari M, Yui K, Kawakami A, Abiru N.
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Journal Title
Diabetologia
Volume: 58 (11)
Issue: 11
Pages: 2606-2614
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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