Role of Prdm16 in hematopoiesis via mitochondrial metabolic pathway

• Project/Area Number: 15K09455
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Kyushu University
• Principal Investigator: KAMEZAKI KENJIRO 九州大学, 大学病院, 講師 (70380433)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 白血病幹細胞

Outline of Final Research Achievements

We revealed that mitochondrial metabolic pathway plays an important role in the maintenance of hematopoietic stem cells. Leukemia stem cells produce glutathione-SH to compete with reactive oxygen species that can be harmful to stem cells. That can be provided via increased expression of amino acid transporters. These findings can lead to establish the targeted therapy of leukemia without any severe adverse effects.

Research Products

• [Journal Article] Antiemetic efficacy and safety of granisetron or palonosetron alone and in combination with a corticosteroid for ABVD therapy-induced nausea and vomiting (2018)
  • Author(s): Uchida Mayako、Nakamura Tsutomu、Hata Kojiro、Watanabe Hiroyuki、Mori Yasuo、Kato Koji、Kamezaki Kenjiro、Takenaka Katsuto、Shiratsuchi Motoaki、Hosohata Keiko、Miyamoto Toshihiro、Akashi Koichi
  • Journal Title: J Pharm Health Care Sci. Volume: 4 Issue: 1
  • DOI: 10.1186/s40780-017-0097-4
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent Subcutaneous Sweet's Disease in a Myelofibrosis Patient Treated with Ruxolitinib before Allogeneic Stem Cell Transplantation (2017)
  • Author(s): Sakoda T, Kanamitsu Y, Mori Y, Sasaki K, Yonemitsu E, Nagae K, Yoshimoto G, Kamezaki K, Kato K, Takenaka K, Miyamoto T, Furue M, Iwasaki H, Akashi K
  • Journal Title: Internal Medicine Volume: 56 Issue: 18 Pages: 2481-2485
  • DOI: 10.2169/internalmedicine.8491-16
  • NAID: 130006078596
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Comparison between Antiemetic Effects of Palonosetron and Granisetron on Chemotherapy-Induced Nausea and Vomiting in Japanese Patients Treated with R-CHOP (2017)
  • Author(s): Uchida Mayako、Mori Yasuo、Nakamura Tsutomu、Kato Koji、Kamezaki Kenjiro、Takenaka Katsuto、Shiratsuchi Motoaki、Kadoyama Kaori、Miyamoto Toshihiro、Akashi Koichi
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 40 Issue: 9 Pages: 1499-1505
  • DOI: 10.1248/bpb.b17-00318
  • NAID: 130006038771
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Successful treatment of Ph ALL with hematopoietic stem cell transplantation from the same HLA-haploidentical related donor of previous liver transplantation (2017)
  • Author(s): Sasaki K, Mori Y, Yoshimoto G, Sakoda T, Kato K, Inadomi K, Kamezaki K, Takenaka K, Iwasaki H, Maeda T, Miyamoto T, Akashi K
  • Journal Title: Leuk Lymphoma. Volume: － Issue: 8 Pages: 1-3
  • DOI: 10.1080/10428194.2017.1403021
  • Peer Reviewed
• [Journal Article] Mobilization of human immature hematopoietic progenitors through combinatory use of bortezomib and immunomodulatory drugs. (2017)
  • Author(s): T. Tochigi, T. Aoki, *Y. Kikushige, T. Kamimura, Y. Ito, T. Shima, T. Yamauchi, Y. Mori, G. Yoshimoto, K. Kamezaki, K. Kato, K. Takenaka, H. Iwasaki, K. Akashi, T. Miyamoto
  • Journal Title: Int J Hematol Volume: 105 Issue: 4 Pages: 423-432
  • DOI: 10.1007/s12185-016-2148-2
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cardiac metastasis of squamous cell carcinoma of the thyroid gland with severe disseminated intravascular coagulation: A case report. (2017)
  • Author(s): Yoshihiro T, Tsuchihashi K, Kusaba H, Nakashima T, Obara T, Nio K, Takayoshi K, Kodama H, Tsuruta N, Kiyohara H, Asai K, Harada E, Kamezaki K, Arita T, Sato M, Yamamoto H, Arita S, Ariyama H, Odashiro K, Oda Y, Akashi K, Baba E.
  • Journal Title: Mol Clin Oncol. Volume: 6 Issue: 1 Pages: 91-95
  • DOI: 10.3892/mco.2016.1091
  • Peer Reviewed
• [Journal Article] Mogamulizumab Treatment Prior to Allogeneic Hematopoietic Stem Cell Transplantation Induces Severe Acute Graft-versus-Host Disease. (2016)
  • Author(s): Sugio T, Kato K, Aoki T, Ohta T, Saito N, Yoshida S, Kawano I, Henzan H, Kadowaki M, Takase K, Muta T, Miyawaki K, Yamauchi T, Shima T, Takashima S, Mori Y, Yoshimoto G, Kamezaki K, Takenaka K, Iwasaki H, Ogawa R, Ohno Y, Eto T, Kamimura T, Miyamoto T, Akashi K.
  • Journal Title: Biol Blood Marrow Transplant. Volume: 22 Issue: 9 Pages: 1608-1614
  • DOI: 10.1016/j.bbmt.2016.05.017
  • Peer Reviewed / Open Access
• [Journal Article] Ascites Retention during Mogamulizumab Treatment in a Patient with Adult T-cell Leukemia/lymphoma (2016)
  • Author(s): Shima T, Kamezaki K, Higashioka K, Takashima S, Yoshimoto G, Kato K, Muta T, Takenaka K, Iwasaki H, Miyamoto T, Akashi K.
  • Journal Title: Internal Medicine Volume: 55 Issue: 13 Pages: 1793-1796
  • DOI: 10.2169/internalmedicine.55.5987
  • NAID: 130005161039
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Successful treatment of adult Langerhans cell histiocytosis with intensified chemotherapy. (2015)
  • Author(s): Minami M, Shima T, Kato K, Yamamoto H, Tsuchihashi K, Oku S, Shimokawa T, Tochigi T, Yoshimoto G, Kamezaki K, Takenaka K, Iwasaki H, Oda Y, Miyamoto T, Akashi K.
  • Journal Title: Int J Hematol. Volume: 102 Pages: 244-8
  • Peer Reviewed / Open Access