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Development of HTLV-1 carrier model mice aming for preventing ATL development

Research Project

Project/Area Number 15K09462
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Hamaguchi Isao  国立感染症研究所, 血液・安全性研究部, 部長 (90348780)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsHTLV-1 / ヒト化マウス / キャリア / モデルマウス / 免疫不全マウス / 経口感染 / 潜伏感染
Outline of Final Research Achievements

We developed humanized mice by using NOJ (NOD/SCID/JAK3 KO) mice. Human hematopoietic stem cells were transplanted into neonatal liver of NOJ mice, HTLV-1 infected cells are administrated through the humanized mice oral. The mice were infected by HTLV-1, and we could analyze the infectious mechanism of HTLV-1 for the long periods.
Furthermore, we have developed new immunodeficient mice with HLA-A*02:01 gene (NOG-HLA-A2 Tg). Hematopoietic stem cells that contained HLA-A*02:01 were transplanted into the humanized mice. These mice would be appropriate for extrapolation to human HTLV-1 carrier.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor.2018

    • Author(s)
      Tezuka K, Okuma K, Kuramitsu M, Matsuoka S, Tanaka R, Tanaka Y, Hamaguchi I.
    • Journal Title

      Journal of Virology

      Volume: 92(4) Issue: 4

    • DOI

      10.1128/jvi.01885-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel neuropilin-1 binding sequence in the human T-cell lymphotropic virus type 1 envelope glycoprotein2018

    • Author(s)
      Kusunoki H, Tanaka T, Kohno T, Matsuhashi K, Hosoda K, Wakamatsu K, Hamaguchi I
    • Journal Title

      Biochim Biophys Acta

      Volume: 1866 Issue: 4 Pages: 541-548

    • DOI

      10.1016/j.bbapap.2018.02.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proviral features of human T cell leukemia virus type 1 in carriers with indeterminate western blot analysis results.2017

    • Author(s)
      Kuramitsu M, Sekizuka T, Yamochi T, Firouzi S, Sato T, Umeki K, Sasaki D, Hasegawa H, Kubota R, Sobata R, Matsumoto C, Kaneko N, Momose H, Araki K, Saito M, Nosaka K, Utsunomiya A, Koh K, Ogata M, Uchimaru K, Iwanaga M, Sagara Y, Yamano Y, et al.
    • Journal Title

      J Clin Microbiol.

      Volume: 55(9) Issue: 9 Pages: 2838-2849

    • DOI

      10.1128/jcm.00659-17

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence of new HTLV-1 infections among adolescents and adults in Japan: a nationwide retrospective cohort analysis of repeat blood donors.2016

    • Author(s)
      Satake M, Iwanaga M, Sagara Y, Watanabe T, Okuma K, Hamaguchi I
    • Journal Title

      Lancet Infect Dis

      Volume: 16 Issue: 11 Pages: 1246-1254

    • DOI

      10.1016/s1473-3099(16)30252-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of the SCF signaling pathway on leukemia stem cell-mediated ATL initiation and progression in an HBZ transgenic mouse model.2016

    • Author(s)
      Kuribayashi W, Takizawa K, Sugata K, Kuramitsu M, Momose H, Sasaki E, Hiradate Y, Furuhata K, Asada Y, Iwama A, Matsuoka M, Mizukami T*, Hamaguchi I*.
    • Journal Title

      Oncotarget

      Volume: 7(32) Issue: 32 Pages: 51027-51043

    • DOI

      10.18632/oncotarget.10210

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Furin-dependent CCL17-fused recombinant toxin controls HTLV-1 infection by targeting and eliminating infected CCR4-expressing cells in vitro and in vivo.2015

    • Author(s)
      Okuma K, Hiyoshi M, Tateyama S, Takizawa K, Saito M, Kuramitsu M, Araki K, Morishita K, Okada S, Yamamoto N, Biragyn A, Yamaguchi K, Hamaguchi I.
    • Journal Title

      Retrovirology

      Volume: 12 Issue: 1 Pages: 1-14

    • DOI

      10.1186/s12977-015-0199-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Standardization of quantitative PCR for human T-cell leukemia virus type 1 in Japan: A collaborative study2015

    • Author(s)
      Kuramitsu M, Okuma K, Yamochi T. et al
    • Journal Title

      J. Clin. Microbien.

      Volume: 53 Issue: 11 Pages: 3485-3491

    • DOI

      10.1128/jcm.01628-15

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Targeting and Eliminating HTLV-1-infected Cells with Cytolytic Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor2017

    • Author(s)
      Kenta Tezuka, Kazu Okuma, Madoka Kuramitsu, Yuetsu Tanaka, Reiko Tanaka, Isao Hamaguchi
    • Organizer
      18th International Conference on Human Retrovirology: HTLV and Related Viruses
    • Place of Presentation
      東京
    • Year and Date
      2017-03-07
    • Related Report
      2016 Research-status Report
  • [Presentation] HTLV-1受容体をコードする組換え水疱性口内炎ウイルスを用いたHTLV-1感染の制御2017

    • Author(s)
      手塚健太、大隈和、倉光球、田中勇悦、田中礼子、浜口功
    • Organizer
      日本HTLV-1学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The c-kit-SCF signaling in the leukemic stem cells development and differentiation in ATL model mice2015

    • Author(s)
      Kuribayashi W, Mizukami T, Takizawa K, Sugata K, Kuramitsu M, Kojima K, Momose H, Asada Y, Iwama A, Matsuoka M, Hamaguchi I
    • Organizer
      日本血液学会
    • Place of Presentation
      金沢
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Patent(Industrial Property Rights)] 組換え水疱性口内炎ウイルスを用いたワクチン・治療薬開発に向けたモニタリングのためのウイルスベクター定量法2017

    • Inventor(s)
      手塚健太、大隈和、浜口功
    • Industrial Property Rights Holder
      手塚健太、大隈和、浜口功
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-131361
    • Filing Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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