| Project/Area Number |
15K09463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Honda Shigenori 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (00303959)
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| Co-Investigator(Kenkyū-buntansha) |
宮田 敏行 国立研究開発法人国立循環器病研究センター, 病院, 非常勤研究員 (90183970)
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| Co-Investigator(Renkei-kenkyūsha) |
Tomiyama Yoshiaki 大阪大学, 医学研究科, 准教授 (80252667)
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| Research Collaborator |
Ikejima Hiroko 国立循環器病研究センター, 研究所, 研究補助者
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | インテグリン / シグナル伝達 |
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| Outline of Final Research Achievements |
β3 integrins are heterodimeric adhesion receptors and members of the integrin superfamily consisted of αIIbβ3 and αVβ3. αIIbβ3, a major integrin expressed on platelets, is critical for platelet aggregation mediated by bindings of fibrinogen and von Willebrand factor. αVβ3 (also called vitronectin receptor), an integrin widely expressed on several cell types including blood vessel tissue constitutive cells and tumor cells, is involved in diverse vascular disease states, tumor proliferation and metastasis.
Kindlins function as an integrin activator that interacts with intracellular proteins such as integrin-linked kinase (ILK). We have reported that ILK is associated with integrin activation. In this study, we investigated the role of each domain of Kindlin-3 in αIIbβ３ activation, and it was suggested that each subdomain could have an important role in αIIbβ3 activation.
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