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Development of the novel therapy for rheumatoid arthritis by micro RNA-containing exosomes

Research Project

Project/Area Number 15K09526
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionKobe University

Principal Investigator

Nakamachi Yuji  神戸大学, 医学部附属病院, 臨床検査技師 (80379429)

Co-Investigator(Kenkyū-buntansha) 河野 誠司  神戸大学, 医学部附属病院, 特命教授 (20351512)
三枝 淳  神戸大学, 医学部附属病院, 講師 (20514970)
笠木 伸平  神戸大学, 医学(系)研究科(研究院), その他 (80457051)
Co-Investigator(Renkei-kenkyūsha) SAEGUSA JUN  神戸大学, 医学部附属病院, 講師 (20514970)
Research Collaborator KASAGI SHINPEI  神戸大学, 医学部附属病院, 助教 (80457051)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsリウマチ学 / エクソソーム / 関節リウマチ / マイクロRNA
Outline of Final Research Achievements

We have reported that miR-124 inhibits the progression of adjuvant-induced arthritis rats by the ankle injection. In this study we investigated whether systemic administration of miR-124-containig exosomes could ameliorate arthritis of mouse collagen induced arthritis (CIA) model. Exosomes carrying miR-124 were separated from culture supernatants of a rheumatoid arthritis synovium cell line and mouse adipose-derived stem cell line which were transfected with miR-124. A single administration of 10μg miR-124-containing exosomes, or multiple administration (three times) of 5 μg exosomes did not significantly inhibit the progression of arthritis in CIA.
It was considered that further qualitative improvement would be necessary to efficiently deliver micro RNA to arthritic joints.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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