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Genetic factors of interstitial lung disease associated with polymyositis and dermatomyositis.

Research Project

Project/Area Number 15K09543
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Collagenous pathology/Allergology
Research InstitutionTokyo National Hospital (Clinical research) (2017)
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital (2015-2016)

Principal Investigator

Tohma Shigeto  独立行政法人国立病院機構東京病院(臨床研究部), 臨床研究部, 院長 (50207528)

Co-Investigator(Kenkyū-buntansha) 古川 宏  筑波大学, 医学医療系, 准教授 (00372293)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords病因・病態 / 多発性筋炎 / 皮膚筋炎
Outline of Final Research Achievements

Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases and are frequently complicated with interstitial lung disease. PM/DM associated interstitial lung disease (PM/DM-ILD) influenced on the prognosis of the patients. Genetic factors of rheumatoid arthritis associated interstitial lung disease have been analyzed and these genetic factors are investigated in this study. HLA-DRB1*08:03 and DPB1*05:01 were associated with the susceptibility of PM/DM and DPB1*02:01 was protectively associated with PM/DM.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (35 results)

All 2018 2017 2016 2015

All Journal Article (22 results) (of which Int'l Joint Research: 22 results,  Peer Reviewed: 22 results,  Open Access: 8 results,  Acknowledgement Compliant: 4 results) Presentation (13 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population.2018

    • Author(s)
      Oka S, Higuchi T, Furukawa H, Nakamura M, Komori A, Abiru S, Nagaoka S, Hashimoto S, Naganuma A, Naeshiro N, Yoshizawa K, Shimada M, Nishimura H, Tomizawa M, Kikuchi M, Makita F, Yamashita H, Ario K, Yatsuhashi H, Tohma S, Kawasaki A, Tsuchiya N, Migita K.
    • Journal Title

      J Hum Genet.

      Volume: 印刷中 Issue: 6 Pages: 739-744

    • DOI

      10.1038/s10038-018-0440-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population2018

    • Author(s)
      A Kawasaki, K Yamashita, F Hirano, KE Sada, D Tsukui, Y Kondo, Y Kimura, K Asako, S Kobayashi, H Yamada, H Furukawa, K Nagasaka, T Sugihara, K Yamagata, T Sumida, S Tohma, H Kono, S Ozaki, S Matsuo, H Hashimoto, H Makino, Y Arimura, M Harigai, N Tsuchiya
    • Journal Title

      Journal of Human Genetics

      Volume: 63 Issue: 1 Pages: 55

    • DOI

      10.1038/s10038-017-0362-2

    • URL

      https://pure.teikyo.jp/en/publications/c184d55b-1ecc-4987-991d-fd64c36d75b6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Biomarker for nontuberculous mycobacterial pulmonary disease in patients with rheumatoid arthritis: anti-glycopeptidolipid core antigen immunoglobulin A antibodies.2018

    • Author(s)
      Iwata K, Oka S, Tsuno H, Furukawa H, Shimada K, Hashimoto A, Komiya A, Tsuchiya N, Katayama M, Tohma S.
    • Journal Title

      Mod Rheumatol.

      Volume: 28 Issue: 2 Pages: 271-275

    • DOI

      10.1080/14397595.2017.1336866

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype2017

    • Author(s)
      Oka Shomi、Furukawa Hiroshi、Yasunami Michio、他
    • Journal Title

      PLOS ONE

      Volume: 12 Issue: 10 Pages: e0187325-e0187325

    • DOI

      10.1371/journal.pone.0187325

    • NAID

      120007128808

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Incidence and risk factors for infections requiring hospitalization, including pneumocystis pneumonia, in Japanese patients with rheumatoid arthritis.2017

    • Author(s)
      Hashimoto A, Suto S, Horie K, Fukuda H, Nogi S, Iwata K, Tsuno H, Ogihara H, Kawakami M, Komiya A, Furukawa H, Matsui M, Tohma S.
    • Journal Title

      Int J Rheumatol.

      Volume: 2017 Pages: 6730812-6730812

    • DOI

      10.1155/2017/6730812

    • NAID

      120007134663

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still's disease.2017

    • Author(s)
      Asano T, Furukawa H, Sato S, Yashiro M, Kobayashi H, Watanabe H, Suzuki E, Ito T, Ubara Y, Kobayashi D, Iwanaga N, Izumi Y, Fujikawa K, Yamasaki S, Nakamura T, Koga T, Shimizu T, Umeda M, Nonaka F, Yasunami M, Ueki Y, Eguchi K, Tsuchiya N, Tohma S, Yoshiura KI, Ohira H, Kawakami A, Migita K.
    • Journal Title

      Arthritis Res Ther.

      Volume: 19 Issue: 1 Pages: 199-199

    • DOI

      10.1186/s13075-017-1406-x

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Response to: ‘HLA-A 31:01 is not associated with the development of methotrexate pneumonitis in the UK population: results from a genome wide association study.’ by Bluett et al.2017

    • Author(s)
      Furukawa H, Oka S, Shimada K, Tsuchiya N, Tohma S, the Rheumatoid Arthritis associated Interstitial Lung Disease Study Consortium.
    • Journal Title

      Ann Rheum Dis.

      Volume: 76 Issue: 12 Pages: e52-e53

    • DOI

      10.1136/annrheumdis-2017-211518

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis.2017

    • Author(s)
      Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, et al.
    • Journal Title

      Ann Rheum Dis.

      Volume: 印刷中 Issue: 6 Pages: 1150-1158

    • DOI

      10.1136/annrheumdis-2016-210645

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The 23-valent pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis: a double-blinded, randomized, placebo-controlled trial.2017

    • Author(s)
      Izumi Y, Akazawa M, Akeda Y, Tohma S, Hirano F, Ideguchi H, Matsumura R, Miyamura T, Mori S, Fukui T, Iwanaga N, Jiuchi Y, Kozuru H, Tsutani H, Saisyo K, Sugiyama T, Suenaga Y, Okada Y, Katayama M, Ichikawa K, Furukawa H, Kawakami K, Oishi K, Migita K.
    • Journal Title

      Arthritis Res Ther.

      Volume: 19 Pages: 15-15

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The Role of Common Protective Alleles HLA-DRB1*13 Among Systemic Autoimmune Diseases.2017

    • Author(s)
      Furukawa H, Oka S, Tsuchiya N, Shimada K, Hashimoto A, Tohma S, Kawasaki A.
    • Journal Title

      Genes Immun.

      Volume: 18 Issue: 1 Pages: 1-7

    • DOI

      10.1038/gene.2016.40

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Plasma miRNA Expression Profiles in Rheumatoid Arthritis Associated Interstitial Lung Disease.2017

    • Author(s)
      Oka S, Furukawa H, Shimada K, Hashimoto A, Komiya A, Fukui N, Tsuchiya N, Tohma S.
    • Journal Title

      BMC Musculoskelet Disord.

      Volume: 18 Issue: 1 Pages: 21-21

    • DOI

      10.1186/s12891-017-1389-4

    • NAID

      120007134825

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1.2017

    • Author(s)
      Higuchi T, Oka S, Furukawa H, Nakamura M, Komori A, Abiru S, Nagaoka S, Hashimoto S, Naganuma A, Naeshiro N, Yoshizawa K, Shimada M, Nishimura H, Tomizawa M, Kikuchi M, Makita F, Yamashita H, Ario K, Yatsuhashi H, Tohma S, Kawasaki A, Ohira H, Tsuchiya N, Migita K.
    • Journal Title

      J Hum Genet.

      Volume: in press Issue: 4 Pages: 481-484

    • DOI

      10.1038/jhg.2016.155

    • NAID

      40021158271

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Association of HLA-G 3' Untranslated region polymorphisms with systemic lupus erythematosus in a Japanese population: A case-control association study2016

    • Author(s)
      Hachiya Y, Kawasaki A, Oka S, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Setoguchi K, Nagai T,Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Kono H, Hirohata S, Takasaki Y, Hashimoto H, Sumida T, Nagaoka S, Tohma S, Furukawa H, Tsuchiya N.
    • Journal Title

      PLoS ONE.

      Volume: 11 Issue: 6 Pages: 22-22

    • DOI

      10.1371/journal.pone.0158065

    • NAID

      120007135354

    • URL

      https://pure.teikyo.jp/en/publications/27bff8f9-afac-4339-b349-252fa8dffd65

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protective role of HLA-DRB1*13:02 against microscopic polyangiitis and MPO-ANCA positive vasculitis in a Japanese population: a case-control study.2016

    • Author(s)
      Kawasaki A, Hasebe N, Hidaka M, Hirano F, Sada K, Kobayashi S, Yamada H, Furukawa H, Yamagata K, Sumida T, Miyasaka N, Tohma S, Ozaki S, Matsuo S, Hashimoto H, Makino H, Arimura Y, Harigai M, Tsuchiya N.
    • Journal Title

      PLoS ONE.

      Volume: 11 Issue: 5 Pages: e0154393-e0154393

    • DOI

      10.1371/journal.pone.0154393

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human leukocyte antigen and systemic sclerosis in japanese: The sign of the four independent protective alleles, DRB1 13:02, DRB1 14:06, DQB1 03:01, and DPB1 02:012016

    • Author(s)
      Furukawa H, Tohma S, Tsuchiya N, et al
    • Journal Title

      PLoS One.

      Volume: 11 Issue: 4 Pages: e0154255-e0154255

    • DOI

      10.1371/journal.pone.0154255

    • NAID

      120007135446

    • URL

      https://pure.teikyo.jp/en/publications/2762e93e-c37c-4485-a9e3-955ba35dfb9e

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neutrophil CD64 is upregulated in RA patients with lymphoma but not in other solid cancers.2016

    • Author(s)
      Komiya A, Matsui T, Horie K, Fukuda H, Iwata K, Tsuno H, Ogihara H, Ikenaka T, Kawakami M, Furukawa H, Hashimoto A, Hirai K, Tohma S.
    • Journal Title

      Mod Rheumatol.

      Volume: 26 Issue: 2 Pages: 216-23

    • DOI

      10.3109/14397595.2015.1078986

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Opsonic and Antibody Responses to Pneumococcal Polysaccharide in Rheumatoid Arthritis Patients Receiving Golimumab Plus Methotrexate.2015

    • Author(s)
      Migita K, Akeda Y, Akazawa M, Tohma S, , Furukawa H, et al
    • Journal Title

      Medicine (Baltimore).

      Volume: ;94(52) Issue: 52 Pages: e2184-e2184

    • DOI

      10.1097/md.0000000000002184

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of abatacept on the immunogenicity of 23-valent pneumococcal polysaccharide vaccination (PPSV23) in rheumatoid arthritis patients.2015

    • Author(s)
      Migita K, Akeda Y, Akazawa M, Tohma S,Furukawa H, Oishi K.et al
    • Journal Title

      Arthritis Res Ther.

      Volume: 10 Issue: 1 Pages: 357-357

    • DOI

      10.1186/s13075-015-0863-3

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neutrophil CD64 for the diagnosis of organizing pneumonia in patients with rheumatoid arthritis.2015

    • Author(s)
      Hashimoto A, Komiya A, Matsui T, Tohma S.
    • Journal Title

      Mod Rheumatol.

      Volume: 23 Pages: 1-2

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.2015

    • Author(s)
      Furukawa H, Oka S, Shimada K, Masuo K, Nakajima F, Funano S, Tanaka Y, Komiya A, Fukui N, Sawasaki T, Tadokoro K, Nose M, Tsuchiya N, Tohma S.
    • Journal Title

      Biomark Insights.

      Volume: 16 Pages: 63-73

    • DOI

      10.4137/bmi.s28209

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Incidence of Symptomatic Vertebral Fractures Among Newly Diagnosed Autoimmune Diseases Initiating Glucocorticoid Therapy.2015

    • Author(s)
      Migita K, Iwanaga N, Imadachi S, Jiuchi Y, Izumi Y, Tsuji Y, Kawahara C, Kawakami A, Furukawa H, Tohma S.
    • Journal Title

      Medicine (Baltimore)

      Volume: 94 Issue: 27 Pages: e875-e875

    • DOI

      10.1097/md.0000000000000875

    • NAID

      120006986908

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetics of Interstitial Lung Disease: Vol de Nuit (Night Flight).2015

    • Author(s)
      Furukawa H, Oka S, Shimada K, Tsuchiya N, Tohma S.
    • Journal Title

      Clin Med Insights Circ Respir Pulm Med.

      Volume: 29 Pages: 1-7

    • DOI

      10.4137/ccrpm.s23283

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 自己免疫性肝炎とTNIP1遺伝子多型の関連2017

    • Author(s)
      岡笑美,古川宏,當間重人,川崎綾,土屋尚之, 右田清志:
    • Organizer
      第28回日本リウマチ学会関東支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 食餌によるメトトレキサート毒性の増強2017

    • Author(s)
      樋口貴士,吉村美郁,岡笑美,川崎綾,蕨栄治,水野聖哉,小野栄夫,高橋智,當間重人,土屋尚之,古川宏:
    • Organizer
      第28回日本リウマチ学会関東支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 関節リウマチとの比較による変形性関節症の滑膜病変の成立機序に関する検討2017

    • Author(s)
      福井尚志,田中信帆,田代俊之,桂川陽三,古川宏,大橋暁,増田公男,岩澤三康,森俊仁,當間重人:
    • Organizer
      第28回日本リウマチ学会関東支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自己免疫性肝炎とTNIP1遺伝子多型の関連2017

    • Author(s)
      岡笑美,古川宏,當間重人,川崎綾,土屋尚之, 右田清志
    • Organizer
      第61回日本リウマチ学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 自己免疫性肝炎とTNIP1遺伝子多型の関連2017

    • Author(s)
      岡笑美,古川宏,當間重人,川崎綾,土屋尚之,右田清志:
    • Organizer
      第71回国立病院総合医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 変形性関節症と関節リウマチの滑膜組織におけるmiRNA の発現比較2017

    • Author(s)
      田中信帆,田代俊之,桂川陽三,古川宏,大橋暁,増田公男,岩澤三康,森俊仁,當間重人,福井尚志:
    • Organizer
      第28回日本リウマチ学会関東支部学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] HLAクラスIIと強皮症2017

    • Author(s)
      古川宏,岡笑美,川崎綾,島田浩太,杉井章二,松下貴史,橋本篤,小宮明子,福井尚志,小林幸司,長田侑,井畑淳,近藤裕也,永井立夫,瀬戸口京吾,岡本明子,岡本享,千葉実行,末松栄一,河野肇,片山雅夫,廣畑俊成,住田孝之,右田清志,長谷川稔,藤本学,佐藤伸一,長岡章平,竹原和彦,當間重人,土屋尚之
    • Organizer
      第20回強皮症研究会議
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] 関節リウマチ関連間質性肺病変における血漿中miRNA2016

    • Author(s)
      岡笑美,古川宏,島田浩太,橋本篤,小宮明子,土屋尚之,當間重人
    • Organizer
      第70回国立病院総合医学会
    • Place of Presentation
      宜野湾
    • Related Report
      2016 Research-status Report
  • [Presentation] 日本人全身性エリテマトーデスとHLA-G多型の関連2016

    • Author(s)
      川崎綾,八谷有紀,古川宏,近藤裕也,伊藤聡,松本功,草生真規雄,天野浩文,須田昭子,長岡章平,瀬戸口京吾,永井立夫,廣畑俊成,島田浩太,杉井章二,岡本享,千葉実行,末松栄一,大野滋,片山雅夫,河野肇,髙崎芳成,橋本博史,住田孝之,當間重人,土屋尚之
    • Organizer
      第60回日本リウマチ学会
    • Place of Presentation
      横浜
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチに合併する間質性肺病変と血漿中miRNA発現2016

    • Author(s)
      岡笑美,古川宏,島田浩太,橋本篤,小宮明子,土屋尚之,當間重
    • Organizer
      第60回日本リウマチ学会
    • Place of Presentation
      横浜
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチに合併する間質性肺病変と抗MICA抗体2015

    • Author(s)
      古川宏、當間重人
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 日本人集団におけるANCA関連血管炎の遺伝素因Genetic Background of ANCA-Associated Vasculitis in the Japanese population.2015

    • Author(s)
      Tsuchiya N, Hasebe N, Hidaka M, Sada K, Kobayashi S, Yamada H, Furukawa H, Yamagata K, Sumida T, Miyasaka N, Tohma S, Ozaki S, Matsuo S, Hashimoto H, Makino H, Arimura Y, Harigai M, Kawasaki A
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] リウマチ性疾患の疾患感受性・薬剤応答性とHLA-新たな知見2015

    • Author(s)
      古川宏、當間重人
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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