Search for a novel anti-pathogen defense system by studying host-pathogen interactions
Project/Area Number |
15K09568
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Infectious disease medicine
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Research Institution | Yamaguchi University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
ASAOKA Yoichi 山口大学, 大学院医学系研究科, 講師 (10436644)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 病原体 / アポトーシス / 免疫 / YAPシグナル |
Outline of Final Research Achievements |
1) In an attempt to elucidate host factor involvement in apoptosis regulation, we found that inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in Hela and MEF cells. 2) To clarify the YAP signaling involvement in the host-pathogen interaction by using small fish medaka as model system, we carried out RNA-seq analysis of YAP knockout medaka. We found that YAP regulates many of the key genes involved in host immune pathway.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] The mevalonate pathway regulates primitive streak formation via protein farnesylation2016
Author(s)
Okamoto-Uchida Y, Yu R, Miyamura N, Arima N, Ishigami-Yuasa M, Kagechika H, Yoshida S, Hosoya T, Nawa M, Kasama T, Asaoka Y, Alois RW, Elling U, Penninger JM, Nishina S, Azuma N, Nishina H
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 37697-37697
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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