2017 Fiscal Year Final Research Report
Search for a novel anti-pathogen defense system by studying host-pathogen interactions
| Project/Area Number |
15K09568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ASAOKA Yoichi 山口大学, 大学院医学系研究科, 講師 (10436644)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 病原体 / アポトーシス / 免疫 / YAPシグナル |
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| Outline of Final Research Achievements |
1) In an attempt to elucidate host factor involvement in apoptosis regulation, we found that inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in Hela and MEF cells.
2) To clarify the YAP signaling involvement in the host-pathogen interaction by using small fish medaka as model system, we carried out RNA-seq analysis of YAP knockout medaka. We found that YAP regulates many of the key genes involved in host immune pathway.
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| Free Research Field |
感染症内科学
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