The investigation of pathophysiology and biomarkers in subacute sclerosing panencephalitis (SSPE)
| Project/Area Number |
15K09654
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HASEGAWA Shunji 山口大学, 大学院医学系研究科, 教授 (90314806)
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| Co-Investigator(Kenkyū-buntansha) |
大賀 正一 九州大学, 医学研究院, 教授 (60233053)
松重 武志 山口大学, 医学部附属病院, 講師 (60528941)
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| Research Collaborator |
ICHIYAMA Takashi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 亜急性硬化性全脳炎 / バイオマーカー / プロテオミクス / トリプトファン代謝 / キノリン酸 |
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| Outline of Final Research Achievements |
Cerebrospinal fluid (CSF) levels of microtubule-associated protein 2 (MAP2) were higher in the patients with SSPE, compared with control group, but not serum levels. In addition, CSF quinolinic acid (QA) levels were increased in the patients with SSPE. Our results show that there may be relationships between CSF MAP2 or QA levels and conditions of SSPE. They may be involved in the pathophysiology of SSPE, and they may be candidates as biomarkers of SSPE.
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Report
(4 results)
Research Products
(4 results)
