Oxysterols in children: potential biomarker for pediatric liver disease

• Project/Area Number: 15K09704
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kurume University
• Principal Investigator: Mizuochi Tatsuki 久留米大学, 医学部, 講師 (20368921)
• Co-Investigator(Renkei-kenkyūsha): KIMURA Akihiko 久留米大学, 医学部, 臨床教授 (00211201)
• Research Collaborator: NITTONO Hiroshi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: オキシステロール / 小児 / 肝臓病 / 肝疾患

Outline of Final Research Achievements

The aim of this study was to clarify whether developmental pattern of oxysterols during childhood are present. We also evaluated whether oxysterols can be a biomarker for pediatric liver disease. There were some significant differences in urinary and serum oxysterols among 5 groups such as Neonate (under 1 month after birth), Infant (1 to 11-month-old), Preschool-age (1 to 6-year-old), School-age (7 to 15-year-old), and Adults (over 18-year-old). In comparing between 8 healthy children and 8 patients with liver disease, total and some kinds of oxysterols in patients with liver disease significantly increased in urine and serum.
We clarified that urinary and serum oxysterols have unique developmental pattern during childhood while may be a useful biomarker for pediatric liver disease.