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Comprehensive analysis of maternal and fetal epigenetic changes during perinatal period

Research Project

Project/Area Number 15K09707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

miyasaka naoyuki  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70313252)

Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsDOHaD / エピゲノム / 注意欠陥多動性障害 / 白血球組成 / マイクロRNA / 慢性疾患 / 先制医療 / DNAメチル化 / miRNA / 周産期
Outline of Final Research Achievements

We have studied the maternal and fetal epigenetic changes during pregnancy using peripheral blood samples, and their association with the maternal environmental factors. Maternal epigenetic changes in lipid metabolism genes (CPT1A and SREBF1) during mid-gestation was similar to those reported in obese women. On the other hand, dynamic changes in methylation levels during pregnancy was affected by not only these metabolic changes but also differences in peripheral leukocyte population. Methylation in attention deficit hyperactivity disorder (ADHD) associated gene (SKI) in cord blood was correlated with protein/energy ratio of the dietary intake in early pregnancy. This finding might be useful for the prevention of ADHD. Finally, circulating exosomal micro RNA level was associated with fetal/placental weight ratio, which indicated that micro RNA might be a biomarker of feto-placental function and fetal growth.

Academic Significance and Societal Importance of the Research Achievements

妊娠中の母体環境が胎児の遺伝子発現調節を修飾し、将来の慢性疾患の要因となること(Developmental Origin of Health and Disease, DOHaD)が注目されている。本研究では、妊娠中の母体栄養摂取や精神状態などの環境因子、母体血、臍帯血のエピゲノム関連因子を測定し、そのメカニズムを検討した。妊娠中の脂質代謝は肥満のそれと類似しているが、代謝変化以外にも細胞組成の影響を受けること、妊娠初期に母体が摂取したたんぱく質エネルギー比が注意欠陥多動性障害関連遺伝子に影響すること、母体血中の循環しているマイクロRNAが胎児胎盤機能の指標となることなどを明らかにした。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017 2015 Other

All Journal Article (8 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (7 results) (of which Int'l Joint Research: 2 results) Remarks (1 results)

  • [Journal Article] Metabolic and Immunological Shifts during Mid-to-Late Gestation Influence Maternal Blood Methylation of CPT1A and SREBF12019

    • Author(s)
      Pavethynath Shilpa、Imai Chihiro、Jin Xin、Hichiwa Naomi、Takimoto Hidemi、Okamitsu Motoko、Tarui Iori、Aoyama Tomoko、Yago Satoshi、Fudono Ayako、Muramatsu Masaaki、Miyasaka Naoyuki、Sato Noriko
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 5 Pages: 1066-1066

    • DOI

      10.3390/ijms20051066

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental Origin of Health and Disease(DOHaD)を理解する新時代の到来―ゲノム・エピゲノムと加齢性慢性疾患の関連性に関する新たな視点2018

    • Author(s)
      佐藤憲子
    • Journal Title

      化学と生物

      Volume: 56 Pages: 613-620

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Porphyromonas gingivalis infection in the placenta and umbilical cord in pregnant mice with low birth weight2018

    • Author(s)
      Udagawa Sayuri、Katagiri Sayaka、Maekawa Shogo、Takeuchi Yasuo、Komazaki Rina、Ohtsu Anri、Sasaki Naoki、Shiba Takahiko、Watanabe Kazuki、Ishihara Kazuyuki、Sato Noriko、Miyasaka Naoyuki、Izumi Yuichi
    • Journal Title

      Acta Odontologica Scandinavica

      Volume: 15 Issue: 6 Pages: 1-9

    • DOI

      10.1080/00016357.2018.1426876

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism2017

    • Author(s)
      Komazaki Rina、Katagiri Sayaka、Takahashi Hirokazu、Maekawa Shogo、Shiba Takahiko、Takeuchi Yasuo、Kitajima Yoichiro、Ohtsu Anri、Udagawa Sayuri、Sasaki Naoki、Watanabe Kazuki、Sato Noriko、Miyasaka Naoyuki、Eguchi Yuichiro、Anzai Keizo、Izumi Yuichi
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 13950-13950

    • DOI

      10.1038/s41598-017-14260-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early gestational maternal low-protein diet diminishes hepatic response to fasting in young adult male mice2017

    • Author(s)
      Sato Noriko、Sudo Katsuko、Mori Masayo、Imai Chihiro、Muramatsu Masaaki、Sugimoto Masahiro
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 9812-9812

    • DOI

      10.1038/s41598-017-10380-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 特集 将来に備えて胎児環境を整えるーDOHaDを学ぼうー企画者のことば2017

    • Author(s)
      宮坂尚幸
    • Journal Title

      産婦人科の実際

      Volume: 66 Pages: 942-942

    • Related Report
      2017 Research-status Report
  • [Journal Article] DOHaD の基礎:DOHaD の分子機構2017

    • Author(s)
      佐藤憲子
    • Journal Title

      産婦人科の実際

      Volume: 66 Pages: 959-966

    • Related Report
      2017 Research-status Report
  • [Journal Article] DOHaDの臨床(胎児):わが国における妊婦の栄養摂取の現状2017

    • Author(s)
      瀧本秀美
    • Journal Title

      産婦人科の実際

      Volume: 66 Pages: 979-986

    • Related Report
      2017 Research-status Report
  • [Presentation] Trimester specific difference in exosomal microRNA expression2019

    • Author(s)
      Ayako Fudono, Noriko Sato, Naoyuki Miyasaka
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 妊娠による炎症関連遺伝子TNFのGene body領域DNAメチル化状態の変化 学会名2018

    • Author(s)
      金昕、今井千裕、Shilpa Pavethynath、飛知和尚美、瀧本秀美、岡光基子、Nay Chi Thun、青山友子、矢郷哲志、不殿絢子、宮坂尚幸、望月和樹、佐藤憲子
    • Organizer
      第7回DOHaD学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 新生児におけるSKI遺伝子ADHD関連部位のDNAメチル化個人差2018

    • Author(s)
      飛知和 尚美、今井 千裕、Shilpa Pavethynath、金 昕、瀧本 秀美、岡光 基子、Nay Chi Thun、青山 友子、矢郷 哲志、不殿 絢子、宮坂 尚幸、佐藤 憲子
    • Organizer
      第41回日本分子生物学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Study design: the evaluation of interindividual differences in neonatal epigenome: the BC-GENIST project2017

    • Author(s)
      Noriko Sato, Hidemi Takimoto, Motoko Okamitsu, Tay Zar Kyaw, Chihiro Imai, Nay Chi Htun, Satoshi Yago, Tomoko Aoyama, Seiji Yamaguchi and Naoyuki Miyasaka
    • Organizer
      The 21st international Epidemiological Association World Congress of Epidemiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dietary intakes from 3-day weighed dietary records among pregnant participants in the Birth Cohort - Gene and ENvironment Interaction Study of TMDU (BC-GENIST)2017

    • Author(s)
      Hidemi Takimoto , Motoko Okamitsu, Noriko Sato, Tay Zar Kyaw, Nay Chi Htun, Chihiro Imai, Yuiri Tsubota, Reiko Tajirika-Shirai, Satoshi Yago, Tomoko Aoyama, Naoyuki Miyasaka
    • Organizer
      The 21st international Epidemiological Association World Congress of Epidemiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 妊娠中の環境要因が影響するエピゲノム変化と母児の健康指標との関連- BC-GENIST-2017

    • Author(s)
      今井千裕、Shilpa Pavethynath, 瀧本秀美、岡光基子、Tay Zar Kyaw, Nay Chi Thun, 五十嵐麻子、青山友子、矢郷哲志、不殿絢子、宮坂尚幸、佐藤憲子.
    • Organizer
      第6回DOHaD学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 使用済み新生児マススクリーニング濾紙血を用いたゲノム・エピゲノム解析の有効性の検討2015

    • Author(s)
      Tay Zar Kyaw
    • Organizer
      日本DOHaD研究会
    • Place of Presentation
      昭和大学(東京 品川区)
    • Year and Date
      2015-08-01
    • Related Report
      2015 Research-status Report
  • [Remarks] 東京医科歯科大学 先制医療実現化DOHaD研究プロジェクト ホームページ

    • URL

      http://www.tmd.ac.jp/ppepi/index.html

    • Related Report
      2018 Annual Research Report 2017 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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