Critical factors for the neonatal bronchopulmonary dysplasia, and development of the inflammation-specific therapeutic strategies

• Project/Area Number: 15K09717
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Kyushu University
• Principal Investigator: Masayuki Ochiai 九州大学, 大学病院, 助教 (90507782)
• Co-Investigator(Kenkyū-buntansha): 井上 普介 九州大学, 大学病院, その他 (90467902)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 新生児 / 周産期 / 早産児 / 呼吸器

Outline of Final Research Achievements

The pathophysiology of neonatal bronchopulmonary dysplasia (BPD) involves underlying multi-factors including immaturity of the fetal lung, oxygen toxicity, baro-/volu-trauma and inflammatory mediators. We previously established “Kyushu University High-Risk Neonatal Clinical Research Network” to conduct a multicenter cohort study. In addition, a new scoring system of chest computed tomography was reported to assess the clinical severity of BPD. We here investigated clinical and biochemical factors associated with the severity of BPD, based on the research platform. The future plans were the biotrauma-specific randomized controlled trials for the high-risk patients, and the inflammation-specific therapeutic strategies.

Research Products

• [Journal Article] Transient Hemi-Lower Limb Ischemia in the Newborn: Arterial Thrombosis or Persistent Sciatic Artery? (2017)
  • Author(s): Kirino M, Ochiai M, Ichiyama M, Inoue H, Kusuda T, Kinjo T, Ishimura M, Ohga S.
  • Journal Title: AJP Rep. Volume: 7(1) Issue: 01 Pages: 13-16
  • DOI: 10.1055/s-0037-1598044
  • Peer Reviewed / Open Access
• [Journal Article] Successful Liver Transplantation for Transient Abnormal Myelopoiesis-Associated Liver Failure (2017)
  • Author(s): Yasuoka Kazuaki、Inoue Hirosuke、Tanaka Koichi、Fujiyoshi Junko、Matsushita Yuki、Ochiai Masayuki、Koga Yuhki、Matsuura Toshiharu、Taguchi Tomoaki、Ohga Shouichi
  • Journal Title: Neonatology Volume: 112 Issue: 2 Pages: 159-162
  • DOI: 10.1159/000474930
  • Peer Reviewed / Open Access
• [Journal Article] High incidence of progressive stenosis in aberrant left subclavian artery with right aortic arch (2017)
  • Author(s): Muraoka Mamoru、Nagata Hazumu、Hirata Yuichiro、Uike Kiyoshi、Terashi Eiko、Morihana Eiji、Ochiai Masayuki、Fujita Yasuyuki、Kato Kiyoko、Yamamura Kenichiro、Ohga Shouichi
  • Journal Title: Heart and Vessels Volume: 33 Issue: 3 Pages: 309-315
  • DOI: 10.1007/s00380-017-1056-6
  • Peer Reviewed
• [Journal Article] Early Mortality and Morbidity in Infants with Birth Weight of 500?Grams or Less in Japan (2017)
  • Author(s): Inoue Hirosuke、Ochiai Masayuki、Yasuoka Kazuaki、Tanaka Koichi、Kurata Hiroaki、Fujiyoshi Junko、Matsushita Yuki、Suga Shutaro、Nonaka Kazuaki、Taguchi Tomoaki、Kato Kiyoko、Ohga Shouichi
  • Journal Title: The Journal of Pediatrics Volume: 190 Pages: 112-117.e3
  • DOI: 10.1016/j.jpeds.2017.05.017
  • Peer Reviewed / Open Access
• [Journal Article] An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis and Bronchopulmonary Dysplasia in Erythropoietin-Treated Very-Low-Birth-Weight Infants. (2017)
  • Author(s): Ochiai M, Kurata H, Inoue H, Tanaka K, Matsushita Y, Fujiyoshi J, Wakata Y, Kato K, Taguchi T, Takada H.
  • Journal Title: Neonatology. Volume: 111 Issue: 1 Pages: 68-75
  • DOI: 10.1159/000447991
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Blood Reference Intervals for Preterm Low-Birth-Weight Infants: A Multicenter Cohort Study in Japan (2016)
  • Author(s): Ochiai M, Matsushita Y, Inoue H, Kusuda T, Kang D, Ichihara K, Nakashima N, Ihara K, Ohga S, Hara T
  • Journal Title: PLoS One Volume: 11 Issue: 8 Pages: e0161439-e0161439
  • DOI: 10.1371/journal.pone.0161439
  • Peer Reviewed / Open Access
• [Presentation] Neonatal Outcomes of Infants with Birth Weight of 500g or Less from the Neonatal Research Network of Japan (2017)
  • Author(s): Inoue H, Yasuoka K, Tanaka K, Kurata H, Ichiyama M, Fujiyoshi J, Matsushita Y, Ochiai M, Ohga S
  • Organizer: The 13th Congress of the Asian Society for Pediatric Research
  • Int'l Joint Research
• [Presentation] Successful Living-Donor Liver Transplantation for Transient Abnormal Myelopoiesis-Associated Liver Failure in an Infant with Down Syndrome (2017)
  • Author(s): Yasuoka K, Inoue H, Tanaka K, Ichiyama M, Fujiyoshi J, Matsushita Y, Ochiai M, Koga Y, Matsuura T, Taguchi T, Ohga S
  • Organizer: The 13th Congress of the Asian Society for Pediatric Research
  • Int'l Joint Research
• [Presentation] 学会主催プログラム 新生児に対する鉄剤投与のガイドライン2017コンセンサスミーティング (2016)
  • Author(s): 板橋家頭夫、萩原亨、落合正行、川口千晴、楠田聡、諏訪敏幸、高橋幸博、田中恭子、中野有也、長谷川真理、平野慎也、松波聡子、三ツ橋偉子
  • Organizer: 第61回日本新生児成育医学会
  • Place of Presentation: 大阪市
  • Year and Date: 2016-12-01
• [Presentation] An Elevation of Serum Ferritin Level Might Increase Clinical Risk for the Persistence of Patent Ductus Arteriosus, Sepsis, and Bronchopulmonary Dysplasia in Erythropoietin-Treated Very Low Birth Weight Infants (2016)
  • Author(s): Ochiai M, Kurata H, Inoue H, Tanaka K, Matsushita Y, Fujiyoshi J, Wakata Y, Kato K, Taguchi T, Takada H
  • Organizer: Asian Society for Pediatric Research 2016
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2016-11-10
  • Int'l Joint Research
• [Presentation] Survival and neonatal morbidity among infants with birth weight 500 g or less in Japan (2016)
  • Author(s): Inoue H, Yasuoka K, Suga S, Tanaka K, Kurata H, Fujiyoshi J, Matsushita Y, Ochiai M, Ohga S, for the Neonatal Research Network of Japan (NRNJ)
  • Organizer: 10th Database Quality Improvement Conference
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2016-10-10
  • Int'l Joint Research
• [Presentation] 極低出生体重児における高フェリチン血症はBPD重症化と関連する (2016)
  • Author(s): 落合正行、倉田浩昭、藤吉順子、井上普介、松下悠紀
  • Organizer: 第29回新生児慢性肺疾患研究会
  • Place of Presentation: 仙台市
  • Year and Date: 2016-10-08
• [Presentation] Sustained Inflammation and Small-for-Gestational Age were associated with Aggravation of Neonatal Bronchopulmonary Dysplasia (2016)
  • Author(s): Hiroaki Kurata, Masayuki Ochiai, Hirosuke Inoue, Takeshi Kusuda, Tadamune Kinjo, Yoshifumi Wakata, Kiyoko Kato, Tomoaki Taguchi, Hidetoshi Takada
  • Organizer: THE NEONATE, An International Symposium For Asia
  • Place of Presentation: Shanghai, China
  • Year and Date: 2016-03-30
  • Int'l Joint Research
• [Presentation] 気管支肺異形成症の重症化に関連する周産期因子とサイトカインプロファイルの解析 (2015)
  • Author(s): 倉田浩昭、落合正行、田中幸一、中村有香里、楠田 剛、井上普介、藤吉順子、松下悠紀、原 寿郎
  • Organizer: 第51回日本周産期・新生児医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2015-07-10
• [Book] 多胎児の管理と予後 双胎児の長期予後 (2016)
  • Author(s): 落合 正行
  • Publisher: 産婦人科の実際