The role of hematopoietic microenvironment in the pathogenesis and spontaneous remission of fetal leukemia
| Project/Area Number |
15K09729
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
Miyauchi Jun 東京歯科大学, 歯学部, 客員教授 (20146707)
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| Co-Investigator(Kenkyū-buntansha) |
川口 裕之 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 小児科学, 准教授 (00313130)
宮下 俊之 北里大学, 医学部, 教授 (60174182)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ダウン症候群 / 胎児性白血病 / 一過性白血病 / 自然治癒 / 造血微小環境 / 胎児造血 / 造血因子 / サイトカイン / 肝臓 / 肝芽細胞 / 乳児白血病 |
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| Outline of Final Research Achievements |
Transient leukemia (TL) in neonates with Down syndrome is a unique fetal leukemia, which arises in fetal liver and spontaneously resolves after birth. Prenatal hematopoietic microenvironment is thought to be relevant to the pathogenesis of TL. We analyzed the functions of hepatoblasts, one of the major constituents of fetal liver hematopoietic microenvironment, on TL cells by using co-culture system. The hepatoblasts produced several human hematopoietic growth factors, including stem cell factor, and stimulated growth and induced megakaryocytic differentiation of TL cells. These data indicate that hematopoietic growth factors produced from fetal liver hematopoietic microenvironment play an important role in the pathogenesis of TL.
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Monocyte chemoattractant protein-1 (MCP-1) as a potential therapeutic target and a noninvasive biomarker of liver fibrosis associated with transient myeloproliferative disorder in Down syndrome2017
Author(s)
Kobayashi K, Yoshioka T, Miyauchi J, Nakazawa A, Yamazaki S, Ono H, Tatsuno M, Iijima K, Takahashi C, Okada Y, Teranishi K, Matsunaga T, Matsushima C, Inagaki M, Suehiro M, Suehiro S, Nishitani M, Kubota H, Iio J, Nishida Y, Katayama T, Takada N, Watanabe K, Yamamoto T, Yasumizu R, Matsuoka K, Ohki K, et al.
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Journal Title
J Pediatr Hematol Oncol
Volume: 39
Related Report
Peer Reviewed / Open Access
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[Journal Article] L-leucine and SPNS1 coordinately ameliorate dysfunction of autophagy in mouse and human Niemann-Pick type C disease.2017
Author(s)
Yanagisawa H, Ishii T, Endo K, Kawakami E, Nagao K, Miyashita T, Akiyama K, Watabe K, Komatsu M, Yamamoto D, Eto Y.
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Journal Title
Sci Rep
Volume: 7
Issue: 1
Pages: 15994-15994
DOI
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Peer Reviewed / Open Access
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[Journal Article] Somatic mosaicism containing double mutations in PTCH1 revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome.2017
Author(s)
Ikemoto, Y., Takayama, Y., Fujii, K., Masuda, M., Kato, C., Hatsuse, H., Fujitani, K., Nagao, K., Kameyama, K., Ikehara, H., Toyoda, M., Umezawa, A. and Miyashita, T.
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Journal Title
Journal of Medical Genetics
Volume: －
Issue: 8
Pages: 579-584
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Gorlin syndrome with an ovarian leiomyoma associated with a PTCH1 second hit2016
Author(s)
Akizawa, Y., Miyashita, T., Sasaki, R., Nagata, R., Aoki, R., Ishitani, K., Nagashima, Y., Matsui, H., Saito, K
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Journal Title
Am J Med A
Volume: 170
Issue: 4
Pages: 1029-1034
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Mirror syndrome associated with fetal transient abnormal myelopoiesis in Down syndrome2015
Author(s)
Kobayashi, Y., Miyoshi, T., Matsuyama, T., Miyauchi, J., Miyashita, T., Ishibashi-Ueda, H. and Yoshimatsu, J.
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Journal Title
Pathology International
Volume: 印刷中
Issue: 8
Pages: 443-445
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A rare case of a symptomatic tumor found in the groin area: An atypical location unexposed to the known causes2015
Author(s)
Toyonaga, E., Hata, H., Nakayama, C., Homma, E., Miyashita, T., Shimizu, H
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Journal Title
Case Rep. Oncol
Volume: 8
Issue: 3
Pages: 536-539
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Intragenic amplification of PAX5 in oediatric B-cell precursor acute lymphoblastic leukemia2015
Author(s)
Yano N, Imamura T, Ohki K, Asai D, Deguchi T, Hashii T, Takahashi H, Kanai R, Yajima S, Kosaka Y, Kawaguchi H, Kikuta A, Sato A
Organizer
第57回小児血液・がん学会
Place of Presentation
甲府市
Year and Date
2015-11-27
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