Maternal-fetal signal relay via placenta regulates the formation of blood-brain barrier in fetal brain cortex
| Project/Area Number |
15K09732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
SHIMADA Hiroki 金沢医科大学, 看護学部, 准教授 (60278108)
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| Co-Investigator(Renkei-kenkyūsha) |
HATTA Toshihisa 金沢医科大学, 医学部, 教授 (20238025)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳発生 / 血液脳関門 / 胎盤 / 白血病抑制因子(LIF) / 副腎皮質刺激ホルモン(ACTH) / 透明化 |
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| Outline of Final Research Achievements |
We previously reported that the materna-fetal signal relay pathway of maternal leukemia inhibitory factor (LIF)-adrenocorticotropic hormone (ACTH)-fetal LIF via the placenta (maternal-fetal LIF signal relay) leaded finally to neurogenesis in the cerebrum of the fetus. In this study, we investigated the role of the signal relay in the formation of blood-brain barrier (BBB) in fetal brain cortex.
Injection of polyriboinosinicpolyribocytidylic acid into dams, which induced maternal immune activation and suppressed maternal-fetal LIF signal relay, accelerated formation of tight junction in BBB and suppressed the transition of interleukin-6 from mother to fetal cerebrospinal fluid. These results indicated that maternal-fetal LIF signal relay regulates BBB formation in fetal brain cortex.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Melanocortins Contribute to Sequential Differentiation and Enucleation of Human Erythroblasts via Melanocortin Receptors 1,2 and 52015
Author(s)
Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T
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Journal Title
PLOS ONE
Volume: 10
Issue: 4
Pages: 1-17
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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