| Project/Area Number |
15K09732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
SHIMADA Hiroki 金沢医科大学, 看護学部, 准教授 (60278108)
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| Co-Investigator(Renkei-kenkyūsha) |
HATTA Toshihisa 金沢医科大学, 医学部, 教授 (20238025)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳発生 / 血液脳関門 / 胎盤 / 白血病抑制因子(LIF) / 副腎皮質刺激ホルモン(ACTH) / 透明化 |
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| Outline of Final Research Achievements |
We previously reported that the materna-fetal signal relay pathway of maternal leukemia inhibitory factor (LIF)-adrenocorticotropic hormone (ACTH)-fetal LIF via the placenta (maternal-fetal LIF signal relay) leaded finally to neurogenesis in the cerebrum of the fetus. In this study, we investigated the role of the signal relay in the formation of blood-brain barrier (BBB) in fetal brain cortex.
Injection of polyriboinosinicpolyribocytidylic acid into dams, which induced maternal immune activation and suppressed maternal-fetal LIF signal relay, accelerated formation of tight junction in BBB and suppressed the transition of interleukin-6 from mother to fetal cerebrospinal fluid. These results indicated that maternal-fetal LIF signal relay regulates BBB formation in fetal brain cortex.
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