| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Mouse skin aging was analyzed by comprehensively comparing gene expression on the skin of parallel mice between elderly and young mice as well as examining the skin of mice of each age, very old, old, young mice by RNA microarray. It was confirmed that genes belonging to early responsive gene including fos, fos-B, atf3, Jun, Jun-B, egr-1, are elevated along with aging, and it is also induced in young mice by serum factor transfer from old mice in parabiotic experiments. The expression of the PTGS2 gene was strongly enhanced as in the aging mice, similarly to the AP1 binding proteins. Thus, it was understood that some factor acts on epidermal keratinocytes, and results in the induction of COX 2 and Caspase 1, and the sustained chronic inflammation on the skin leads to the skin damage and aging.
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