| Project/Area Number |
15K09819
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Department of Clinical Research, National Hospital Organization Kure Medical Center |
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Principal Investigator |
Takebayashi Minoru 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他(移行) (60304440)
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| Co-Investigator(Kenkyū-buntansha) |
上園 保仁 国立研究開発法人国立がん研究センター, 研究所, 分野長 (20213340)
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| Co-Investigator(Renkei-kenkyūsha) |
OKADA MAMI 国立病院機構呉医療センター, 中国がんセンター 臨床研究部, 研究員 (30517280)
MIYANO KANAKO 国立がん研究センター, 研究所, 研究員 (50597888)
HASHIMOTO ERI 札幌医科大学, 医学部, 准教授 (30301401)
UKAI WATARU 札幌医科大学, 医学部, 准教授 (40381256)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | うつ病 / グリア / 抗うつ薬 / 抗うつ薬受容体 / リゾホスファチジン酸受容体１ / アストロサイト |
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| Outline of Final Research Achievements |
I revealed that “antidepressant receptors” on glia were lysophosphatidic acid receptors 1 (LPA1). I also found that antidepressants may have stimulatory effects on LPA1.Further, I found that both blood and cerebrospinal fluid (CSF) levels of autotaxin (ATX), a synthase of LPA, in patients with depression were significantly reduced when compared to healthy controls. Therefore, these results demonstrated a possibility that pathophysiology of depression might be related to abnormality in ATX-LPA axis and that the mechanism of LPA1 activation on glia might be useful for development of antidepressants.
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