A pharmacological and clinical study of G protein-coupled antidepressant receptors on astrocytes
Project/Area Number |
15K09819
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Department of Clinical Research, National Hospital Organization Kure Medical Center |
Principal Investigator |
Takebayashi Minoru 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他(移行) (60304440)
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Co-Investigator(Kenkyū-buntansha) |
上園 保仁 国立研究開発法人国立がん研究センター, 研究所, 分野長 (20213340)
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Co-Investigator(Renkei-kenkyūsha) |
OKADA MAMI 国立病院機構呉医療センター, 中国がんセンター 臨床研究部, 研究員 (30517280)
MIYANO KANAKO 国立がん研究センター, 研究所, 研究員 (50597888)
HASHIMOTO ERI 札幌医科大学, 医学部, 准教授 (30301401)
UKAI WATARU 札幌医科大学, 医学部, 准教授 (40381256)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | うつ病 / グリア / 抗うつ薬 / 抗うつ薬受容体 / リゾホスファチジン酸受容体1 / アストロサイト |
Outline of Final Research Achievements |
I revealed that “antidepressant receptors” on glia were lysophosphatidic acid receptors 1 (LPA1). I also found that antidepressants may have stimulatory effects on LPA1.Further, I found that both blood and cerebrospinal fluid (CSF) levels of autotaxin (ATX), a synthase of LPA, in patients with depression were significantly reduced when compared to healthy controls. Therefore, these results demonstrated a possibility that pathophysiology of depression might be related to abnormality in ATX-LPA axis and that the mechanism of LPA1 activation on glia might be useful for development of antidepressants.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Identification of lysophosphatidic acid receptor 1 in astroglial cells as a target for glial cell line-derived neurotrophic factor expression induced by antidepressants.2016
Author(s)
Kajitani, N., Miyano, K., Okada-Tsuchioka, M., Abe, H., Itagaki, K., Hisaoka-Nakashima, K., Morioka, N., Uezono, Y., Takebayashi, M.
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Journal Title
J Biol Chem
Volume: 291
Issue: 53
Pages: 27364-27370
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia.2016
Author(s)
Hisaoka-Nakashima K, Kajitani N, Kaneko M, Shigetou T, Kasai M, Matsumoto C, Yokoe T, Azuma H, Takebayashi M, Morioka N, Nakata Y
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Journal Title
Brain Res
Volume: 1634
Pages: 57-67
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Amitriptyline induces brain-derived neurotrophic factor (BDNF) mRNA expression through ERK-dependent modulation of multiple BDNF mRNA variants in primary cultured rat cortical astrocytes and microglia.2016
Author(s)
Hisaoka-Nakashima K, Kajitani N, Kaneko M, Shigetou T, Kasai M, Matsumoto C, Yokoe T, Azuma H, Takebayashi M, Morioka N, Nakata Y.
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Journal Title
Brain Research
Volume: 1634
Pages: 57-67
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] ricyclic antidepressant amitriptyline-induced glial cell line-derived neurotrophic factor production involves pertussis toxin-sensitive Gi/oactivation in astroglial cells2015
Author(s)
Hisaoka-Naashima K, Miyano K, Matsumoto C, Kajitani N , Abe H, Okada-Tsuchioka M, Yokoyama A, Uezono Y, Morioka N, Nakata Y, Takebayashi M
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Journal Title
Journal of Biological Chemistry
Volume: 290
Pages: 13678-13691
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Reduced serum and cerebrospinal fluid levels of autotaxin in major depressive disorder2017
Author(s)
Itagaki K, Abe H, Shibasaki C, Omori W, Kajitani N, Abe H, Okada-Tsuchioka M, Hattori K, Yoshida S, Kunugi H, Takebayashi M
Organizer
47th Annual Meeting of Society for Neuroscience
Related Report
Int'l Joint Research
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