Clinicopathological study for differential radiological diagnosis of dementia
Project/Area Number |
15K09824
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Yokohama City University (2018-2019) Nagoya University (2015-2017) |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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Keywords | 老人斑 / アミロイド / 神経原線維変化 / レビー病理 / レビー小体 / シヌクレイン / ドパミントランスポーター / 脳血流 / レビー小体病 / うつ病 / 自律神経障害 / レム睡眠行動障害 / 睡眠ポリグラフ検査 / 黒質 / 基底核ドパミントランスポーター / MIBG心筋シンチグラフィー / 神経変性疾患 / タウ / グレイン / 4リピートタウオパチー / 嗜銀顆粒 / 嗜銀顆粒病 / 神経画像 / アルツハイマー病 / 抑うつ / 身体症状症 |
Outline of Final Research Achievements |
In the recent research criteria, the prodromal phase of dementia with Lewy bodies includes psychiatric-onset presentations. However, its clinicopathological features remains unclear. In 36 autopsy cases with diffuse Lewy body disease, clinical and pathological variables were statistically compared among three groups according to initial symptoms. The severity of parkinsonism was significantly greater in the parkinsonism group than those in the psychotic state and memory disturbance. As to pathological findings, the median senile plaque score was significantly higher in the memory disturbance group than in the other groups. These results support the fact that cerebral β-amyloid accumulation contributes to determining the clinical phenotypes in terms of the timing the onset of dementia relative to that of parkinsonism in Lewy body dementia. Further clinicopathological studies with specific biomarker data are needed to clarify disease progression patterns in Lewy body dementia.
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Academic Significance and Societal Importance of the Research Achievements |
老年期にはじめて精神症状が出現する脳病態、とくに病理学的背景は明らかになっていない。しかし、近年の脳機能画像やレビー小体病の知見が蓄積されているが、症候学的による分類に基づく診療が実施されているのが現状である。レビー小体病は、病初期に精神症状が前景化する場合があり、老年期発症の精神疾患の鑑別診断に重要であるが、その方法は確立されていない。レビー小体病を早期に鑑別することは、薬物療法の選択ばかりでなく、認知機能低下を含む臨床経過を把握するうえで重要である。また、臨床病理学的知見の更なる蓄積は、今後の疾患修飾薬を見据え、貴重と考えられる。
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Report
(6 results)
Research Products
(122 results)
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[Journal Article] Research criteria for the diagnosis of prodromal dementia with Lewy bodies.2020
Author(s)
McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O’Brien JT, Postuma RB, Tiraboschi P
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Journal Title
Neurology
Volume: 94
Issue: 17
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Globular glial tauopathy Type I presenting with bvFTD2020
Author(s)
Hirano M, Iritani S, Fujishiro H, Torii Y, Sekiguchi H, Habuchi C, Yamada K, Ikeda T, Hasegawa M, Ikeuchi T, Yoshida M, Ozaki N.
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Journal Title
Neuropathology
Volume: -
Issue: 5
Pages: 515-525
DOI
Related Report
Peer Reviewed
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[Journal Article] The neuropathological study of myelin oligodendrocyte glycoprotein in the temporal lobe of schizophrenia patients.2018
Author(s)
Marui T,Torii Y, Iritani S, Sekiguchi H, Habuchi C, Fujishiro H,,Oshima K, Niizato K, Hayashida S, Masaki K, Kira J,Ozaki N.
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Journal Title
Acta Neuropsychiatr
Volume: 22
Issue: 4
Pages: 1-9
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of hypnotics on prefrontal cortex activity during a verbal fluency task in healthy male subjects: A near-infared spectroscopy study.2018
Author(s)
Tsuruta Y, Iwamoto K, Banno M, Kawano N, Kohmura K, Miyata S, Fujishiro H, Noda Y, Noda A, Iritani S, Ozaki N.
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Journal Title
Hum Psychopharmacol
Volume: 33
Issue: 6
DOI
Related Report
Peer Reviewed
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[Journal Article] Risk of alcohol use relapse after liver transplantation for alcoholic liver disease2017
Author(s)
Yasuharu Onishi, Hiroyuki Kimura, Tomohide Hori, Shinichi Kishi, Hideya Kamei, Nobuhiko Kurata, Chisato Tsuboi, Naoko Yamaguchi, Mayu Takahashi, Saki Sunada, Mitsuaki Hirano, Hiroshige Fujishiro, Takashi Okada, Masatoshi Ishigami, Hidemi Goto, Norio Ozaki, Yasuhiro Ogura
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Journal Title
World Journal of Gastroenterology
Volume: 23
Issue: 5
Pages: 869-875
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.2017
Author(s)
McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, et al.
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Journal Title
Neurology
Volume: 89
Issue: 1
Pages: 88-100
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Successful Post-Transplant Psychiatric Interventions During Long-Term Follow-Up of Patients Receiving Liver Transplants for Alcoholic Liver Disease.2017
Author(s)
Kimura H, Onishi Y, Kishi S, Kurata N, Ogiso S, Kamei H, Tsuboi C, Yamaguchi N, Shiga A, Kondo M, Yokoyama Y, Takasato F, Fujishiro H, Ishizuka K, Okada T, Ogura Y, Ozaki N.
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Journal Title
Am J Case Rep
Volume: 18
Pages: 1215-1219
Related Report
Peer Reviewed
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[Journal Article] An autopsy case of cortical superficial siderosis with persistent abnormal behavior.2016
Author(s)
Torii Y,Iritani S, Fujishiro H, Sekiguchi H, Habuchi C, Umeda K, Matsunaga S, Mimuro M, Ozaki N, Yoshida M, Fujita K.
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Journal Title
Neuropathology
Volume: 36
Issue: 6
Pages: 544-550
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Autopsy-confirmed hippocampal-sparing Alzheimer’s disease with delusional jealousy as initial manifestation.2015
Author(s)
Fujishiro H, Iritani S, Hattori M, Sekiguchi H, Matsunaga S, Habuchi C, Torii Y, Umeda K, Ozaki N, Yoshida M, Fujita K.
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Journal Title
Psychogeriatrics
Volume: 15
Issue: 3
Pages: 198-203
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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