Development of supplementary laboratory test for the differential diagnosis of depression

• Project/Area Number: 15K09832
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Yamaguchi University
• Principal Investigator: MATSUO Koji 山口大学, 大学院医学系研究科, 准教授 (00292912)
• Co-Investigator(Kenkyū-buntansha): 山形 弘隆 山口大学, 医学部附属病院, 講師 (10549934) ; 藤田 悠介 山口大学, 大学院創成科学研究科, 准教授 (40509527) ; 松原 敏郎 山口大学, 大学教育機構, 准教授 (60526896)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 神経画像 / MRI / 遺伝子 / 脳体積 / 遺伝子発現 / うつ病 / 双極性障害 / 気分障害 / 前部帯状回 / 島領域 / エンドフェノタイプ

Outline of Final Research Achievements

We examined biological marker for the differential diagnosis of depression and bipolar disorder using MR imaging and gene expression. We found that patients with depression showed abnormal gray matter volume and white matter integrity of frontal and temporal regions. Patients with depression demonstrated abnormal gene expressions, which were observed in depression-like mice. These findings are suggested to be potentially biomarker for the differential diagnosis of depression and bipolar disorder.

Research Products

• [Int'l Joint Research] The University of Texas(米国)
• [Int'l Joint Research] University of Texas(U.S.A.)
• [Journal Article] Altered Connectivity of the Anterior Cingulate and the Posterior Superior Temporal Gyrus in a Longitudinal Study of Later-life Depression (2018)
  • Author(s): Harada Kenichiro、Ikuta Toshikazu、Nakashima Mami、Watanuki Toshio、Hirotsu Masako、Matsubara Toshio、Yamagata Hirotaka、Watanabe Yoshifumi、Matsuo Koji
  • Journal Title: Frontiers in Aging Neuroscience Volume: 10 Pages: 1-11
  • DOI: 10.3389/fnagi.2018.00031
  • Peer Reviewed / Open Access
• [Journal Article] Altered plasma protein glycosylation in a mouse model of depression and in patients with major depression (2018)
  • Author(s): Yamagata Hirotaka、Uchida Shusaku、Matsuo Koji、Harada Kenichiro、Kobayashi Ayumi、Nakashima Mami、Higuchi Fumihiro、Watanuki Toshio、Matsubara Toshio、Watanabe Yoshifumi
  • Journal Title: Journal of Affective Disorders Volume: 233 Pages: 79-85
  • DOI: 10.1016/j.jad.2017.08.057
  • Peer Reviewed
• [Journal Article] Differences in frontotemporal dysfunction during social and non-social cognition tasks between patients with autism spectrum disorder and schizophrenia (2018)
  • Author(s): Hirata Keiko、Egashira Kazuteru、Harada Kenichiro、Nakashima Mami、Hirotsu Masako、Isomura Shinji、Watanuki Toshio、Matsubara Toshio、Kaku Yoichi、Kaneyuki Hiroshi、Watanabe Yoshifumi、Matsuo Koji
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41598-018-21379-w
  • Peer Reviewed / Open Access
• [Journal Article] Identification of commonly altered genes between in major depressive disorder and a mouse model of depression (2017)
  • Author(s): Yamagata Hirotaka、Uchida Shusaku、Matsuo Koji、Harada Kenichiro、Kobayashi Ayumi、Nakashima Mami、Nakano Masayuki、Otsuki Koji、Abe-Higuchi Naoko、Higuchi Fumihiro、Watanuki Toshio、Matsubara Toshio、Miyata Shigeo、Fukuda Masato、Mikuni Masahiko、Watanabe Yoshifumi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 3044-3044
  • DOI: 10.1038/s41598-017-03291-x
  • Peer Reviewed / Open Access
• [Journal Article] Disconnectivity between Dorsal Raphe Nucleus and Posterior Cingulate Cortex in Later Life Depression (2017)
  • Author(s): Ikuta Toshikazu、Matsuo Koji、Harada Kenichiro、Nakashima Mami、Hobara Teruyuki、Higuchi Naoko、Higuchi Fumihiro、Otsuki Koji、Shibata Tomohiko、Watanuki Toshio、Matsubara Toshio、Yamagata Hirotaka、Watanabe Yoshifumi
  • Journal Title: Frontiers in Aging Neuroscience Volume: 9 Pages: 236-236
  • DOI: 10.3389/fnagi.2017.00236
  • Peer Reviewed / Open Access
• [Journal Article] Effects of task language and second-language proficiency on the neural correlates of phonemic fluency in native Japanese speakers (2017)
  • Author(s): Wroblewski Greggory J.、Matsuo Koji、Hirata Keiko、Matsubara Toshio、Harada Kenichiro、Watanabe Yoshifumi、Shinoda Koh
  • Journal Title: NeuroReport Volume: 28 Issue: 14 Pages: 884-889
  • DOI: 10.1097/wnr.0000000000000852
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Distinctive Neuroanatomical Substrates for Depression in Bipolar Disorder versus Major Depressive Disorder (2017)
  • Author(s): Matsuo Koji、Harada Kenichiro、Fujita Yusuke、Okamoto Yasumasa、Ota Miho、Narita Hisashi、Mwangi Benson、Gutierrez Carlos A、Okada Go、Takamura Masahiro、Yamagata Hirotaka、Kusumi Ichiro、Kunugi Hiroshi、Inoue Takeshi、Soares Jair C、Yamawaki Shigeto、Watanabe Yoshifumi
  • Journal Title: Cerebral Cortex Volume: 29 Issue: 1 Pages: 202
  • DOI: 10.1093/cercor/bhx319
  • URL: https://pure.teikyo.jp/en/publications/4de8afcf-5b94-43c7-8eec-8d8ae223beea
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder. (2017)
  • Author(s): Ikeda M, Shimasaki A, Takahashi A,et al.
  • Journal Title: Mol Psychiatry Volume: in press Issue: 3 Pages: 1-9
  • DOI: 10.1038/mp.2016.259
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Abnormal asymmetries in subcortical brain volume in schizophrenia. (2016)
  • Author(s): Okada, N.;Nemoto, K.;Hibar, D. P.;van Erp, T. G.;Fujino, H.;Isobe, M.;Isomura, S.;Natsubori, T.;Narita, H.;Hashimoto, N.;Miyata, J.;Koike, S.; Suzuki, M.;Turner, J. A.; Ozaki, N.;Kasai, K.;Hashimoto, R.
  • Journal Title: Mol Psychiatry Volume: － Issue: 10 Pages: 1460-6
  • DOI: 10.1038/mp.2015.209
  • NAID: 120007129397
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Disrupted orbitomedial prefrontal limbic network in individuals with later-life depression (2016)
  • Author(s): Harada K, Matsuo K, Nakashima M, Hobara T, Higuchi N, Higuchi F, Nakano M, Otsuki K, Shibata T, Watanuki T, Matsubara T, Fujita Y, Shimoji K, Yamagata H, Watanabe Y
  • Journal Title: Journal of Affective Disorders Volume: 204 Pages: 112-119
  • DOI: 10.1016/j.jad.2016.06.031
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders. (2016)
  • Author(s): Matsubara T, Matsuo K, Harada K, Nakano M, Nakashima M, Watanuki T, Egashira K, Furukawa M, Matsunaga N, Watanabe Y.
  • Journal Title: PLoS One Volume: 28 Issue: 12 Pages: 1-16
  • DOI: 10.1371/journal.pone.0168493
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Blood transcriptomic markers in patients with late-onset major depressive disorder (2016)
  • Author(s): Miyata S, Kurachi M, Okano Y, Sakurai N, Kobayashi A, Harada K, Yamagata H, Matsuo K, Takahashi K, Narita K, Fukuda M, Ishizaki Y, Mikuni M
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0150262-e0150262
  • DOI: 10.1371/journal.pone.0150262
  • Peer Reviewed / Open Access
• [Journal Article] Exome sequencing for bipolar disorder points to roles of de novo loss-of-function and protein-altering mutations (2016)
  • Author(s): Kataoka M, Matoba N, Sawada T, Kazuno A, Ishiwata M, Fujii K, Matsuo K, Takata A, Kato T
  • Journal Title: Molecular Psychiatry Volume: in press
  • Peer Reviewed
• [Journal Article] Blunted brain activation in patients with schizophrenia in response to emotional cognitive inhibition: A functional near-infrared spectroscopy study (2015)
  • Author(s): Egashira K, Matsuo K, Nakashima M, Watanuki T, Harada K, Nakano M, Matsubara T, Takahashi K, Watanabe Y
  • Journal Title: Schizophrenia Research Volume: 162 Issue: 1-3 Pages: 196-204
  • DOI: 10.1016/j.schres.2014.12.038
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Altered Connectivity of the Anterior Cingulate and the Posterior Superior Temporal Gyrus in a Longitudinal Study of Later-life Depression (2017)
  • Author(s): Harada K, Ikuta T, Nakashima M, Watanuki T, Hirotsu M, Matsubara T, Yamagata H, Watanabe Y, Matsuo K.
  • Organizer: 第39回日本生物学的精神医学会
• [Presentation] Different fronto-temporal activation during emotional and cognitive tasks in patients with unipolar and bipolar depression: A functional near-infrared spectroscopy study. (2016)
  • Author(s): Matsubara T, Matsuo K, Harada K, Nakashima M, Nakano M, Hirotsu M, Hirata K, Higuchi N, Watanuki T, Higuchi F, Yamagata H, Watanabe Y
  • Organizer: 18th Annual Conference of the International Society for Bipolar Disorders Held Jointly with the 8th Biennial Conference of the International Society for Affective Disorders
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2016-07-13
  • Int'l Joint Research
• [Presentation] Structural and functional brain abnormalities in patients with late-life depression: a longitudinal MRI study of multiple imaging analysis. (2016)
  • Author(s): Harada K, Matsuo K, Nakashima M, Hobara T, Higuchi N, Higuchi F, Nakano M, Otsuki K, Shibata T, Watanuki T, Ikuta T, Matsubara T, Yamagata H, Watanabe Y
  • Organizer: 18th Annual Conference of the International Society for Bipolar Disorders Held Jointly with the 8th Biennial Conference of the International Society for Affective Disorders
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2016-07-13
  • Int'l Joint Research
• [Presentation] Distinct and shared morphometric biomarkers of depressed individuals with bipolar disorder and major depressive disorder (2016)
  • Author(s): Matsuo K, Fujita Y, Harada K, Inoue T, Kunugi H, Kusumi I, Narita H, Okada G, Okamoto Y, Ota M, Takamura M, Watanabe Y, Yamagata H, Yamawaki S
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-03
  • Int'l Joint Research
• [Presentation] Distinction of brain morphometric abnormalities in bipolar and unipolar depression: A voxel-based multi-center study (2015)
  • Author(s): Matsuo K, Harada K, Okamoto Y, Ohta M, Narita H, Fujita Y, Okada G, Takamura M, Yamagata H, Kusumi I, Inoue T, Kunugi H, Yamawaki S, Watanabe Y
  • Organizer: Neuroscience 2015
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-17
  • Int'l Joint Research
• [Presentation] Different fronto-temporal activation during an emotional word task in patients with unipolar and bipolar depression: A functional near-infrared spectroscopy study (2015)
  • Author(s): Matsubara T, Matsuo K, Harada K, Nakashima M, Nakano M, Hirotsu M, Hirata K, Higuchi N, Watanuki T, Higuchi F, Otsuki K, Shibata T, Hobara T, Yamagata H, Watanabe Y
  • Organizer: Society of Biological Psychiatry 70th Annual Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Reduced Gray-matter Volume of Fronto-temporal Cortex in Patients with Late-life Depression (2015)
  • Author(s): Harada K, Matsuo K, Yamagata H, Nakashima M, Nakano M, Higuchi N, Higuchi F, Hobara T, Otsuki K, Shibata T, Watanuki T, Ueda K, Furukawa M, Fukunaga M, Fujita Y, Shimoji K, Matubata T, Matsunaga N, Watanabe Y
  • Organizer: Society of Biological Psychiatry 70th Annual Meeting
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2015-05-14
  • Int'l Joint Research