Longitudinal study on the elucidation of actual state of dementia and its risk/protective factors in Hisayama elderly residents
Project/Area Number |
15K09835
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
吉田 大悟 九州大学, 医学研究院, 共同研究員 (10596828)
二宮 利治 九州大学, 大学病院, 助教 (30571765)
神庭 重信 九州大学, 医学研究院, 教授 (50195187)
清原 裕 九州大学, 医学研究院, 教授 (80161602)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 認知症 / アルツハイマー型認知症 / 血管性認知症 / 有病率 / 発症率 / 予後 / 危険因子 / 家庭血圧 / 日間変動 / 罹患率 / 時代的変化 |
Outline of Final Research Achievements |
To examine secular trends in the prevalence of clinically-diagnosed dementia and its subtypes, five cross-sectional surveys were conducted among Hisayama residents aged 65 years or older in 1985, 1992, 1998, 2005, and 2012. The age- and sex-adjusted prevalence of all-cause dementia, especially Alzheimer’s disease (AD), increased significantly from 1985 to 2012. This steep increase in prevalence may have been caused by the increasing incidence of dementia and the improvement of the survival rate of individuals with dementia, in addition to the rapid aging of the population. To evaluate the risk factor for dementia, about 1,000 elder residents without dementia in Hisayama Town were followed up prospectively. As a result, tooth loss was a significant risk factor for the development of dementia. In addition, increased day-to-day blood pressure variability was significantly associated with higher risks of all-cause dementia, AD, and vascular dementia.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Albuminuria increases the risks for both Alzheimer disease and vascular dementia in community-dwelling Japanese elderly: the Hisayama Study.2018
Author(s)
Takae K, Hata J, Ohara T, Yoshida D, Shibata M, Mukai N, Hirakawa Y, Kishimoto H, Tsuruya K, Kitazono T, Kiyohara Y, Ninomiya T
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Journal Title
J Am Heart Assoc
Volume: 7
Related Report
Peer Reviewed
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[Journal Article] Trends in dementia prevalence, incidence, and survival rate in a Japanese community2017
Author(s)
Ohara T, Hata J, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y.
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Journal Title
Neurology
Volume: 印刷中
Issue: 20
Pages: 1925-1932
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study.2017
Author(s)
Oishi E, Ohara T, Sakata S, Fukuhara M, Hata J, Yoshida D, Shibata M, Ohtsubo T, Kitazono T, Kiyohara Y, Ninomiya T.
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Journal Title
Circulation
Volume: 136
Issue: 6
Pages: 516-525
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Alternative measures of hyperglycemia and risk of alzheimer's disease in the community: the Hisayama Study.2017
Author(s)
Mukai N, Ohara T, Hata J, Hirakawa Y, Yoshida D, Kishimoto H, Koga M, Nakamura U, Kitazono T, Kiyohara Y, Ninomiya T
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Journal Title
J Clin Endocrinol Metab
Volume: 102
Issue: 8
Pages: 3002-3010
DOI
Related Report
Peer Reviewed
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[Journal Article] The changing prevalence and incidence of dementia over time ? current evidence2017
Author(s)
Wu Yu-Tzu、Beiser Alexa S.、Breteler Monique M. B.、Fratiglioni Laura、Helmer Catherine、Hendrie Hugh C.、Honda Hiroyuki、Ikram M. Arfan、Langa Kenneth M.、Lobo Antonio、Matthews Fiona E.、Ohara Tomoyuki、P?r?s Karine、Qiu Chengxuan、Seshadri Sudha、Sj?lund Britt-Marie、Skoog Ingmar、Brayne Carol
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Journal Title
Nature Reviews Neurology
Volume: 13
Issue: 6
Pages: 327-339
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The long-term association between physical activity and risk of dementia in the community: the Hisayama Study.2016
Author(s)
Hiro Kishimoto, Tomoyuki Ohara, Jun Hata, Toshiharu Ninomiya, Daigo Yoshida, Naoko Mukai, Masaharu Nagata, Fumie Ikeda, Masayo Fukuhara, Shuzo Kumagai, Shigenobu Kanba, Takanari Kitazono, Yutaka Kiyohara.
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Journal Title
Euro J Epidemiol
Volume: 31
Issue: 3
Pages: 267-274
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between diabetes and hippocampal atrophy in elderly Japanese: the Hisayama Study.2016
Author(s)
4.Hirabayashi N, Hata J, Ohara T, Mukai N, Nagata M, Shibata M, Gotoh S, Furuta Y, Yamashita F, Yoshihara K, Kitazono T, Sudo N, Kiyohara Y, Ninomiya T
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Journal Title
Diabetes Care
Volume: 39
Issue: 9
Pages: 1543-1549
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Type 2 diabetes as a risk factor for dementia in women compared with men: a pooled analysis of 2.3 million people comprising more than 100,000 cases of dementia2016
Author(s)
Chatterjee S, Peters SA, Woodward M, Mejia Arango S, Batty GD, Beckett N, Beiser A, Borenstein AR, Crane PK, Haan M, Hassing LB, Hayden KM, Kiyohara Y, Larson EB, Li CY, Ninomiya T, Ohara T, Peters R, Russ TC, Seshadri S, Strand BH, Walker R, Xu W, Huxley RR
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Journal Title
Diabetes Care
Volume: 39
Issue: 2
Pages: 300-307
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Serum angiopoietin-like protein 2 (ANGPTL2) is a novel risk factor for cardiovascular disease in the community: the Hisayama Study.2016
Author(s)
Hata J, Mukai N, Nagata M, Ohara T, Yoshida D, Kishimoto H, Shibata M, Hirakawa Y, Endo M, Ago T, Kitazono T, Oike Y, Kiyohara Y & Ninomiya T.
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 36
Issue: 8
Pages: 1686-1691
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Combination of <i>Helicobacter pylori</i> Antibody and Serum Pepsinogen as a Good Predictive Tool of Gastric Cancer Incidence: 20-Year Prospective Data From the Hisayama Study2016
Author(s)
5.Ikeda F, Shikata K, Hata J, Fukuhara M, Hirakawa Y, Ohara T, Mukai N, Nagata M, Yoshida D, Yonemoto K, Esaki M, Kitazono T, Kiyohara Y, Ninomiya T
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Journal Title
Journal of Epidemiology
Volume: 26
Issue: 12
Pages: 629-636
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Midlife and late-life smoking and risk of dementia in the community: the Hisayama Study2015
Author(s)
Ohara T, Ninomiya T, Hata J, Ozawa M, Yoshida D, Mukai N, Nagata M, Iwaki T, Kitazono T, Kanba S, Kiyohara Y
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Journal Title
J Am Geriatr Soc
Volume: 63
Issue: 11
Pages: 2332-2339
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A genome-wide association study of late-onset Alzheimer's disease in a Japanese population.2015
Author(s)
Hirano A, Ohara T, Takahashi A, Aoki M, Fuyuno Y, Ashikawa K, Morihara T, Takeda M, Kamino K, Oshima E, Okahisa Y, Shibata N, Arai H, Akatsu H, Ikeda M, Iwata N, Ninomiya T, Monji A, Kitazono T, Kiyohara Y, Kubo M, Kanba S.
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Journal Title
Psychiatr Genet.
Volume: 25(4)
Issue: 4
Pages: 139-146
DOI
Related Report
Peer Reviewed
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