• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Detecting cortical gamma band oscillation deficit in first-episode schizophrenia and clinical high risk subjects

Research Project

Project/Area Number 15K09836
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

Hirano Yoji  九州大学, 大学病院, 助教 (90567497)

Co-Investigator(Kenkyū-buntansha) 神庭 重信  九州大学, 医学研究院, 教授 (50195187)
Research Collaborator Onitsuka Toshiaki  
Oribe Naoya  
Spencer Kevin  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords初発統合失調症 / クリニカルハイリスク群 / ガンマ帯域皮質活動 / ガンマオシレーション / 脳波 / バイオマーカー / 脳機能 / 進行性の障害 / 統合失調症 / ハイリスク群 / 神経発達障害仮説 / 脳磁図 / 認知機能 / 未治療群 / ガンマ帯皮質活動
Outline of Final Research Achievements

We detected neurophysiological changes of auditory cortex function (early auditory-evoked gamma-band oscillation) in first episode schizophrenia patients during a one-year period, which were not observed in individuals at clinical high risk. These progressive functional gamma-band oscillation abnormalities may underlie neurodevelopmental models of schizophrenia, which would be a useful biomarker for early detection and intervention.

Academic Significance and Societal Importance of the Research Achievements

本研究により、統合失調症の発症後に、既に報告されている進行性の脳構造異常に加え、進行性の聴覚情報処理に関わる脳機能異常が生じていることが示唆され、統合失調症の進行性の神経発達障害仮説を脳の機能面からも裏付ける重要な知見が得られた。つまり、統合失調症の進行性の脳機能異常を食い止めるためにも、早期の治療介入が重要であり、本研究で用いた指標であるガンマオシレーションが、早期の診断や脳機能評価に関わるバイオマーカーとして有用であることが示された。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (54 results)

All 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (6 results) Journal Article (19 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 17 results,  Open Access: 8 results,  Acknowledgement Compliant: 6 results) Presentation (25 results) (of which Int'l Joint Research: 17 results,  Invited: 12 results) Book (3 results) Remarks (1 results)

  • [Int'l Joint Research] Harvard Medical School/University of Massachusetts(米国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] National Taiwan University(中国)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] The University of New South Wales(オーストリア)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Harvard Medical School/Neural Dynamics Laboratory/Psychiatry Neuroimaging Laboratory(米国)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Harvard Medical School/VA Boston Healthcare System/Psychiatry Neuroimaging Laboratory(米国)

    • Related Report
      2016 Research-status Report
  • [Int'l Joint Research] Harvard Medical School/VA Boston Healthcare System/Neural Dynamics Laboratory(米国)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Progressive reduction of auditory evoked gamma in first episode schizophrenia but not clinical high risk individuals2019

    • Author(s)
      Oribe Naoya、Hirano Yoji、del Re Elisabetta、Seidman Larry J.、Mesholam-Gately Raquelle I.、Woodberry Kristen A.、Wojcik Joanne D.、Ueno Takefumi、Kanba Shigenobu、Onitsuka Toshiaki、Shenton Martha E.、Goldstein Jill M.、Niznikiewicz Margaret A.、McCarley Robert W.、Spencer Kevin M.
    • Journal Title

      Schizophrenia Research

      Volume: In Press Pages: 145-152

    • DOI

      10.1016/j.schres.2019.03.025

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuroanatomical substrate of chronic psychosis in epilepsy: an MRI study2019

    • Author(s)
      Hirakawa Noriaki、Kuga Hironori、Hirano Yoji、Sato Jinya、Oribe Naoya、Nakamura Itta、Hirano Shogo、Ueno Takefumi、Oda Yuko、Togao Osamu、Hiwatashi Akio、Honda Hiroshi、Kanba Shigenobu、Onitsuka Toshiaki
    • Journal Title

      Brain Imaging and Behavior

      Volume: In Press Issue: 5 Pages: 1382-1387

    • DOI

      10.1007/s11682-019-00044-4

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormalities of eye movement are associated with work hours in schizophrenia.2018

    • Author(s)
      Morita K, Miura K, Fujimoto M, Shishido E, Shiino T, Takahashi J, Yamamori H, Yasuda Y, Kudo N, Hirano Y, Koshiyama D, Okada N, Ikeda M, Onitsuka T, Ozaki N, Kasai K, Hashimoto R.
    • Journal Title

      Schizophr Res

      Volume: 202 Pages: 420-422

    • DOI

      10.1016/j.schres.2018.06.064

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phase-Amplitude Coupling of the EEG in the Auditory Cortex in Schizophrenia2018

    • Author(s)
      Hirano S, Nakhnikian A, Hirano Y, Oribe N, Kanba S, Onitsuka T, Levin M, Spencer KM
    • Journal Title

      Biol Psychiatry Cogn Neurosci Neuroimaging

      Volume: 3 Issue: 1 Pages: 69-76

    • DOI

      10.1016/j.bpsc.2017.09.001

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Creativity and arts in psychiatry2018

    • Author(s)
      Hirano Yoji、Hosaka Kenjiro
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 72 Issue: 1 Pages: 1-1

    • DOI

      10.1111/pcn.12617

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Artwork Description2018

    • Author(s)
      Hosaka Kenjiro、Hirano Yoji
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 72 Issue: 2 Pages: 132-132

    • DOI

      10.1111/pcn.12619

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Altered sulcogyral patterns of orbitofrontal cortex in a large cohort of patients with schizophrenia2017

    • Author(s)
      Isomura S, Hashimoto R, Nakamura M, Yamashita F, Jimbo S, Hirano Y, Yamamori H, Fujimoto M, Yasuda Y, Mears R, Onitsuka T
    • Journal Title

      nature partner journal Schizophrenia

      Volume: 3 Issue: 1 Pages: 1-4

    • DOI

      10.1038/s41537-016-0008-y

    • Related Report
      2018 Annual Research Report 2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Right hemisphere pitch-mismatch negativity reduction in patients with major depression: An MEG study.2017

    • Author(s)
      Hirakawa N, Hirano Y, Nakamura I, Hirano S, Sato J, Oribe N, Ueno T, Kanba S, Onitsuka T.
    • Journal Title

      J Affect Disord.

      Volume: 215 Pages: 225-229

    • DOI

      10.1016/j.jad.2017.03.046

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 精神疾患におけるバイオマーカーとしての脳波・脳磁図2017

    • Author(s)
      平野羊嗣, 高橋潤一, 鬼塚俊明
    • Journal Title

      分子精神医学

      Volume: 17 Pages: 160-169

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 統合失調症のガンマ帯域活動異常2017

    • Author(s)
      平野羊嗣
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 28 Pages: 88-94

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] わたしの研究 ボストン留学体験記2017

    • Author(s)
      平野羊嗣
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 28 Pages: 201-202

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differentiation between major depressive disorder and bipolar disorder by auditory steady-state responses2016

    • Author(s)
      Isomura S, Onitsuka T, Tsuchimoto R, Nakamura I, Hirano S, Oda Y, Oribe N, Hirano Y, Ueno T, Kanba S
    • Journal Title

      Journal of Affective Disorders

      Volume: 190 Pages: 800-806

    • DOI

      10.1016/j.jad.2015.11.034

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Increased BOLD Signals Elicited by High Gamma Auditory Stimulation of the Left Auditory Cortex in Acute State Schizophrenia.2016

    • Author(s)
      Kuga H, Onitsuka T, Hirano Y, Nakamura I, Oribe N, Mizuhara H, Kanai R, Kanba S, Ueno T
    • Journal Title

      EBioMedicine

      Volume: 12 Pages: 143-149

    • DOI

      10.1016/j.ebiom.2016.09.008

    • NAID

      120005997816

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 統合失調症の聴覚皮質におけるγ帯域活動異常と体積異常(MINI REVIEW)2016

    • Author(s)
      平野羊嗣
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 27 Pages: 94-94

    • Related Report
      2016 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] 統合失調症の聴覚皮質におけるγ帯域自発活動2016

    • Author(s)
      平野羊嗣
    • Journal Title

      九州神経精神医学誌

      Volume: 61 Pages: 128-131

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Spontaneous gamma activity in schizophrenia2015

    • Author(s)
      Hirano Y, Oribe N, Kanba S, Onitsuka T, Nestor PG, Spencer KM
    • Journal Title

      JAMA Psychiatry

      Volume: 印刷中 Issue: 8 Pages: 813-821

    • DOI

      10.1001/jamapsychiatry.2014.2642

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early Integration Processing between Faces and Vowel Sounds in Human Brain: An MEG Investigation2015

    • Author(s)
      Nakamura I, Hirano Y, Ohara N, Hirano S, Ueno T, Tsuchimoto R, Kanba S, Onitsuka T
    • Journal Title

      Neuropsychobiology

      Volume: 71 Issue: 4 Pages: 187-195

    • DOI

      10.1159/000377680

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Progressive Reduction of Visual P300 Amplitude in Patients With First-Episode Schizophrenia: An ERP Study2015

    • Author(s)
      Oribe N, Hirano Y, Kanba S, Del Re E, Seidman L, Mesholam-Gately R, Goldstein JM, Shenton M, Spencer KM, McCarley RW, Niznikiewicz M
    • Journal Title

      Schizophrenia Bulletin

      Volume: 41 Issue: 2 Pages: 460-470

    • DOI

      10.1093/schbul/sbu083

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 神経生理学的研究からみた統合失調症のGABA機能障害2015

    • Author(s)
      平野羊嗣
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 26 Pages: 199-203

    • NAID

      130005395609

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Progressive spontaneous and synchrony gamma-band oscillation deficits in first episode schizophrenia (SIRS Young Investigator Award)2018

    • Author(s)
      Yoji Hirano
    • Organizer
      The 2018 Congress of The Schizophrenia International Research Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Abnormal cortical activities in psychosis: toward translational research.2018

    • Author(s)
      Yoji Hirano, Kevin Spencer
    • Organizer
      21st International Conference on Biomagnetism
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neural Oscillation Abnormalities in Psychosis (Cutting-edge translational research in schizophrenia -from neurophysiological perspective-)2018

    • Author(s)
      Yoji Hirano
    • Organizer
      The 40th Annual Meeting of JSBP
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Abnormal Neural Oscillation and Auditory Hallucination in Schizophrenia2018

    • Author(s)
      Yoji Hirano
    • Organizer
      The International Consortium on Hallucination Research 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 若手研究者育成プログラム:プログレスレポート2018

    • Author(s)
      平野羊嗣
    • Organizer
      第40回日本生物学的精神医学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 統合失調症の神経生理学的研究 -ここまで分かった統合失調症-2018

    • Author(s)
      平野羊嗣
    • Organizer
      第13回日本統合失調症学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Progressive spontaneous and synchrony gamma-band oscillation deficits in first episode schizophrenia (SIRS Award, by invitation)2018

    • Author(s)
      HIrano Y
    • Organizer
      6th Biennial Schizophrenia International Research Society Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Hirano Y, Nakanishi S, Oda Y, Nakamura I, Takei Y, Kanba S, Onitsuka T2017

    • Author(s)
      Altered Gamma Oscillation Patterns During Name Recognition in Schizophrenia
    • Organizer
      International Congress on Schizophrenia Research 2017
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sensory processing dysfunction in psychosis (symposium)2017

    • Author(s)
      HIrano Y
    • Organizer
      International Society for the Advancement of Clinical MEG -Biomagnetic Sendai 2017-
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Progressive auditory gamma oscillation deficit in clinical high-risk subjects and first- episode schizophrenia (TSSR Award, by invitation)2017

    • Author(s)
      HIrano Y
    • Organizer
      Taiwanese Society of Schizophrenia Research Meeting 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Coincidental disruption of gamma rhythms in first episode schizophrenia2017

    • Author(s)
      Hirano Y, Oribe N, Onitsuka T, Kanba S, McCarley RW, Spencer KM
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Facial Emotion Processing in Schizophrenia using Newly Created Facial Stimuli by Japanese Actors; fMRI study2017

    • Author(s)
      Oribe N, Kuga H, Takao H, Fukushima S, Hirano Y, Onitsuka T, Ueno.T
    • Organizer
      Society for Neuroscience 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合失調症の神経生理学的研究:エキスパートレクチャー2016

    • Author(s)
      平野羊嗣
    • Organizer
      第46回日本臨床神経生理学会学術大会
    • Place of Presentation
      郡山
    • Year and Date
      2016-10-29
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 統合失調症のガンマ帯域神経活動異常2016

    • Author(s)
      平野羊嗣
    • Organizer
      第38回日本生物学的精神医学会 合同シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 統合失調症の聴覚皮質におけるγ帯域活動異常と体積異常:プログレスレポート2016

    • Author(s)
      平野羊嗣
    • Organizer
      第38回日本生物学的精神医学会若手研究者育成プログラム
    • Place of Presentation
      福岡
    • Year and Date
      2016-09-10
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Whole Brain Analysis of Spontaneous Gamma Activity in Schizophrenia2016

    • Author(s)
      Nakhnikian A, Hirano Y, Oribe N, Niznikiewicz MA, Spencer KM
    • Organizer
      Society of Biological Psychiatry 71st Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Translatable Biomarkers of Schizophrenia: Assessment of Three NMDA Receptor Antagonistbased Pharmacological Mouse Models of Schizophrenia Using the Auditory Steady State Response (ASSR)2016

    • Author(s)
      Levin ME, Richardson KA, Eric Buerger E, Hirano Y, Spencer KM, Gerber D
    • Organizer
      Society of Biological Psychiatry 71st Annual Meeting
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2016-05-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gamma band auditory steady-state responses in first episode psychosis, schizophrenia, bipolar disorder and major depressive disorder: An ERP study2015

    • Author(s)
      Oribe N, Kuga H, Nakamura I, Hirano Y, Onitsuka T, and Ueno T
    • Organizer
      Neuroscience 2015
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-19
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 統合失調症の聴覚皮質におけるγ帯域活動異常と体積異常2015

    • Author(s)
      平野羊嗣
    • Organizer
      第37回日本生物学的精神医学会 若手研究者育成プログラム
    • Place of Presentation
      東京都
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 統合失調症の視聴覚統合機能障害の評価:脳磁図研究2015

    • Author(s)
      中村一太, 平野羊嗣, 平野昭吾, 鬼塚俊明
    • Organizer
      第37回日本生物学的精神医学会
    • Place of Presentation
      東京都
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
  • [Presentation] 統合失調症者の視聴覚統合機能異常に対する脳磁図を用いた評価2015

    • Author(s)
      中村一太, 平野羊嗣, 平野昭吾, 鬼塚俊明
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      兵庫県
    • Year and Date
      2015-07-30
    • Related Report
      2015 Research-status Report
  • [Presentation] Reduced auditory evoked oscillations and underlying structural abnormality in Schizophrenia2015

    • Author(s)
      Hirano Y, Oribe N, Kanba S, Onitsuka T, McCarley RW, Spencer KM
    • Organizer
      OHBM 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-06-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Abnormal face-voice integration in schizophrenia: A magnetoencephalography study2015

    • Author(s)
      Nakamura I, Hirano Y, Hirano S, Ueno T, Onitsuka
    • Organizer
      OHBM 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-06-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gamma oscillation deficit in clinical high-risk subjects2015

    • Author(s)
      Hirano Y
    • Organizer
      15th International Congress on Schizophrenia Research
    • Place of Presentation
      Colorado Springs, Colorado, USA
    • Year and Date
      2015-04-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Progressive auditory gamma oscillation deficit in clinical high-risk subjects and first-episode schizophrenia2015

    • Author(s)
      Hirano Y, Oribe N, Onitsuka T, Kanba S, McCarley RW, Spencer KM
    • Organizer
      15th International Congress on Schizophrenia Research
    • Place of Presentation
      Colorado Springs, Colorado, USA
    • Year and Date
      2015-04-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] ブレインサイエンス・レビュー2017

    • Author(s)
      平野羊嗣(分担)・監修 廣川信隆
    • Total Pages
      308
    • Publisher
      クバプロ
    • Related Report
      2017 Research-status Report
  • [Book] ブレインサイエンス・レビュー 20172017

    • Author(s)
      平野羊嗣(分担: 監修 廣川信隆)
    • Total Pages
      308
    • Publisher
      KUBAPRO
    • Related Report
      2016 Research-status Report
  • [Book] 精神科のくすりハンドブック第二版(分担: 監修 樋口輝彦)2016

    • Author(s)
      平野羊嗣
    • Total Pages
      373
    • Publisher
      総合医学社
    • Related Report
      2016 Research-status Report
  • [Remarks] 九州大学大学院医学研究院 精神病態医学 業績

    • URL

      https://www.med.kyushu-u.ac.jp/psychiatry/

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-02-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi