Pathogenesis and diagnostic approach for cerebral amyloid angiopathy by focusing transient focal neurological episodes

• Project/Area Number: 15K09837
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kumamoto University
• Principal Investigator: Nakajima Makoto 熊本大学, 医学部附属病院, 特任教授 (90530147)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 神経症候学 / 脳表ヘモジデローシス / 限局性くも膜下出血 / 一過性脳局所徴候 / 脳皮質下出血 / 脳表へモジデローシス / 一過性局所神経徴候

Outline of Final Research Achievements

We reported that TFNE was detected in not a few patients in acute stroke hospitals and neuroimaging using MRI was the key for diagnosis. The difference in TFNE between A-beta type and ATTR type amyloid angiopathy were compared: patients with ATTR type amyloidosis demonstrated hallucination more frequently than those with A-beta type amyloid angiopathy. In memory clinic, we found that cortical superficial siderosis was strongly associated with Alzheimer disease and also with strictly lobar microbleeds. SRPX1 was detected as an important constitute of arteries in CAA patients. Finally, we reviewed literatures regarding drugs for vascular cognitive impairment.

Research Products

• [Journal Article] Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment (2017)
  • Author(s): Smith EE, Cieslak A, Barber P, Chen J, Chen YW, Donnini I, Edwards JD, Frayne R, Field TS, Hegedus J, Hanganu V, Ismail Z, Kanji J, Nakajima M, Noor R, Peca S, Sahlas D, Sharma M, Sposato LA, Swartz RH, Zerna C, Black SE, Hachinski V.
  • Journal Title: J Am Heart Assoc Volume: 6 Issue: 5
  • DOI: 10.1161/jaha.117.005568
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Successful switching of anticoagulants in a patient with superficial siderosis and atrial fibrillation (2016)
  • Author(s): Inatomi Y, Nakajima, M, Yonehara T, ANdo Y
  • Journal Title: Neurology and Clinical Neuroscience Volume: 5 Issue: 1 Pages: 36-38
  • DOI: 10.1111/ncn3.12094
  • Peer Reviewed / Open Access
• [Journal Article] Diagnostic significance of cortical superficial siderosis for Alzheimer’s disease in patients with cognitive impairment. (2016)
  • Author(s): Inoue Y, Nakajima M, Uetani H, Hirai T, Ueda M, Kitajima M, Utsunomiya D, Watanabe M, Hashimoto M, Ikeda M, Yamashita Y, Ando Y.
  • Journal Title: AJNR Am J Neuroradiol Volume: 37 Issue: 2 Pages: 223-227
  • DOI: 10.3174/ajnr.a4496
  • Peer Reviewed / Open Access
• [Presentation] Comparison of clinical features in transient focal neurological episodes between hereditary transthyretin type and Aß type cerebral amyloid angiopathy (2018)
  • Author(s): Nakajima M, Takeuchi Y, Nagao Y, Masuda T, Yamashita T, Terasaki T, Ando Y.
  • Organizer: International Symposium on Amyloidosis
  • Int'l Joint Research
• [Presentation] 脳アミロイドアンギオパチーの臨床像 (2016)
  • Author(s): 中島誠，井上泰輝，山下太郎，安東由喜雄
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] 脳アミロイドアンギオパチーのメカニズムとその予防への応用 (2016)
  • Author(s): 井上泰輝，中島誠，山下太郎，安東由喜雄
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-18
• [Presentation] 一過性神経脱落徴候を呈した患者における脳表ヘモジデローシス (2016)
  • Author(s): 長尾洋一郎，中島誠，平原智雄，和田邦泰，寺崎修司，安東由喜雄
  • Organizer: 第41回日本脳卒中学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2016-04-14