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Pathogenesis and diagnostic approach for cerebral amyloid angiopathy by focusing transient focal neurological episodes

Research Project

Project/Area Number 15K09837
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionKumamoto University

Principal Investigator

Nakajima Makoto  熊本大学, 医学部附属病院, 特任教授 (90530147)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経症候学 / 脳表ヘモジデローシス / 限局性くも膜下出血 / 一過性脳局所徴候 / 脳皮質下出血 / 脳表へモジデローシス / 一過性局所神経徴候
Outline of Final Research Achievements

We reported that TFNE was detected in not a few patients in acute stroke hospitals and neuroimaging using MRI was the key for diagnosis. The difference in TFNE between A-beta type and ATTR type amyloid angiopathy were compared: patients with ATTR type amyloidosis demonstrated hallucination more frequently than those with A-beta type amyloid angiopathy. In memory clinic, we found that cortical superficial siderosis was strongly associated with Alzheimer disease and also with strictly lobar microbleeds. SRPX1 was detected as an important constitute of arteries in CAA patients. Finally, we reviewed literatures regarding drugs for vascular cognitive impairment.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment2017

    • Author(s)
      Smith EE, Cieslak A, Barber P, Chen J, Chen YW, Donnini I, Edwards JD, Frayne R, Field TS, Hegedus J, Hanganu V, Ismail Z, Kanji J, Nakajima M, Noor R, Peca S, Sahlas D, Sharma M, Sposato LA, Swartz RH, Zerna C, Black SE, Hachinski V.
    • Journal Title

      J Am Heart Assoc

      Volume: 6 Issue: 5

    • DOI

      10.1161/jaha.117.005568

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful switching of anticoagulants in a patient with superficial siderosis and atrial fibrillation2016

    • Author(s)
      Inatomi Y, Nakajima, M, Yonehara T, ANdo Y
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 5 Issue: 1 Pages: 36-38

    • DOI

      10.1111/ncn3.12094

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic significance of cortical superficial siderosis for Alzheimer’s disease in patients with cognitive impairment.2016

    • Author(s)
      Inoue Y, Nakajima M, Uetani H, Hirai T, Ueda M, Kitajima M, Utsunomiya D, Watanabe M, Hashimoto M, Ikeda M, Yamashita Y, Ando Y.
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 37 Issue: 2 Pages: 223-227

    • DOI

      10.3174/ajnr.a4496

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Comparison of clinical features in transient focal neurological episodes between hereditary transthyretin type and Aß type cerebral amyloid angiopathy2018

    • Author(s)
      Nakajima M, Takeuchi Y, Nagao Y, Masuda T, Yamashita T, Terasaki T, Ando Y.
    • Organizer
      International Symposium on Amyloidosis
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳アミロイドアンギオパチーの臨床像2016

    • Author(s)
      中島誠,井上泰輝,山下太郎,安東由喜雄
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳アミロイドアンギオパチーのメカニズムとその予防への応用2016

    • Author(s)
      井上泰輝,中島誠,山下太郎,安東由喜雄
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 一過性神経脱落徴候を呈した患者における脳表ヘモジデローシス2016

    • Author(s)
      長尾洋一郎,中島誠,平原智雄,和田邦泰,寺崎修司,安東由喜雄
    • Organizer
      第41回日本脳卒中学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2016-04-14
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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