The effects of cognitive remediation on the activatity of the reward systems in schizophrenia

• Project/Area Number: 15K09866
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tottori University
• Principal Investigator: Kaneko Koichi 鳥取大学, 医学部, 教授 (50194907)
• Research Collaborator: PU Shenhong ; ITAKURA Masashi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 統合失調症 / 認知機能障害 / 認知リハビリテーション / 動機付け / 報酬系 / fMRI / 脳内報酬系 / 内発的動機付け / 磁気共鳴画像 / 構造的結合性 / 機能的結合性 / 拡散テンソル画像法 / 陰性症状 / 自己効力感 / ドーパミン系

Outline of Final Research Achievements

We investigated the effects of NEAR, which is one method of cognitive remediation therapy, on motivational states of the participants assessed with "Quality of Life Scale (QLS)" and on functional connectivity between the pairs of brain regions within brain reward system measured with resting-state functional magnetic resonance imaging.
After three months of NEAR, the score of the "Motivation" item increased by 2.1 points compared with that assessed at baseline. On the other hand, NEAR did not affect functional connectivity between any pair of two brain regions within brain reward system. The finding that NEAR did not influence the functional connectivity may result from two factors: the contribution of the brain regions outside the reward system and methodological issues on defining region of interest within the brain reward system.

Research Products

• [Int'l Joint Research] The University of Texas Health Center(米国)
• [Int'l Joint Research]
• [Journal Article] Association of fronto-temporal function with cognitive ability in schizophrenia. (2017)
  • Author(s): Pu S, Nakagome K, Itakura M, Iwata M, Nagata, Kaneko K.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1
  • DOI: 10.1038/srep42858
  • Peer Reviewed
• [Journal Article] Social cognition and prefrontal hemodynamic responses during a working memory task in schizophrenia (2016)
  • Author(s): Pu S, Nakagome K, Yamada T, Itakura M, Yamanashi T, Yamada S, Masai M, Miura A, Yamauchi T, Satake T, Iwata M, Nagata I, Roberts DL,Kaneko K
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 1-9
  • DOI: 10.1038/srep22500
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 認知機能障害と陰性症状のリカバリーを中心に (2016)
  • Author(s): 兼子幸一
  • Organizer: 第11回日本統合失調症学会
  • Place of Presentation: ベイシア文化ホール(群馬県前橋市)
  • Year and Date: 2016-03-25
  • Invited