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cognitive dysfunctioning and its process in the people with ARMS

Research Project

Project/Area Number 15K09876
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionToho University

Principal Investigator

MIZUNO Masafumi  東邦大学, 医学部, 教授 (80245589)

Co-Investigator(Kenkyū-buntansha) 辻野 尚久  東邦大学, 医学部, 講師 (00459778)
根本 隆洋  東邦大学, 医学部, 准教授 (20296693)
Research Collaborator INOUE Naomi  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords精神病発症危険状態 / 精神病発症超ハイリスク / 移行例・非移行例 / ロールシャッハ検査 / ARMS / At-risk mental state / Ultra-high risk / 減弱精神病症候群
Outline of Final Research Achievements

The objective of this study was to detect reliable markers of developing psychosis, ranging from an at-risk mental state (ARMS) to full-blown psychosis.
Of the 18 individuals with ARMS who completed a 2-year follow-up, 4 developed psychosis. Among four transitioners, two had overincorporative information processing style (subtype 1), as assessed by the Rorschach Comprehensive System (CS); the other two had an underincorporative information processing style (subtype 2). The former cognitive functioning style is known to be typical of full-blown schizophrenia; the latter appears to be a new cognitive marker of potential clinical value in predicting psychosis outcomes among ARMS populations.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (18 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Peer Reviewed: 5 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (7 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results) Book (3 results)

  • [Journal Article] An open-label study of cognitive behavioural therapy for individuals with at-risk mental state: feasibility in the Japanese clinical setting2018

    • Author(s)
      Matsumoto K, Ohmuro N, Tsujino N, Nishiyama S, Abe K, Hamaie Y, Katsura M, Inoue N, Matsuoka H, Kawasaki Y, Kishimoto T, Suzuki M, Mizuno M.
    • Journal Title

      Early Intervention in Psychiatry

      Volume: 25 Issue: 1 Pages: 31-40

    • DOI

      10.1111/eip.12541

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stigma toward psychosis and its formulation process: Prejudice and discrimination against early stages of schizophrenia2017

    • Author(s)
      Yoko Baba, Takahiro Nemoto, Naohisa Tsujino, Taiju Yamaguchi, Naoyuki Katagiri, Masafumi Mizuno
    • Journal Title

      Comprehensive Psychiatry

      Volume: 73 Pages: 181-186

    • DOI

      10.1016/j.comppsych.2016.11.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identifying comorbidities of patients at ultra-high risk for psychosis using the Rorschach comprehensive system.2016

    • Author(s)
      Naomi Inoue, Yuko Yorozuya, Tomoyuki Funatogawa, Taiju Yamaguchi, Naoyuki Katagiri, Naohisha Tsujino, Takahiro Nemoto, Masafumi Mizuno
    • Journal Title

      Journal of Psychopathology and Projective Tests

      Volume: 25 Pages: 31-40

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Heterogeneity of risk for psychosis within subjects at clinical high risk: Meta-analytical stratification.2016

    • Author(s)
      Fusar-Poli P, Mizuno M, et al.
    • Journal Title

      JAMAPsychiatry

      Volume: 73 Issue: 2 Pages: 113-20

    • DOI

      10.1001/jamapsychiatry.2015.2324

    • Related Report
      2015 Research-status Report
  • [Journal Article] Characteristics of motivation and their impacts on the functional outcomes in patients with schizophrenia.2016

    • Author(s)
      Miki Tobe, Takahiro Nemoto, Naohisa Tsujino, Taiju Yamaguchi, Naoyuki Katagiri, Chiyo Fujii, Masafumi Mizuno
    • Journal Title

      Comprehensive Psychiatry

      Volume: 65 Pages: 103-109

    • DOI

      10.1016/j.comppsych.2015.10.006

    • Related Report
      2015 Research-status Report
  • [Journal Article] Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset2015

    • Author(s)
      Shinya Ito, Takahiro Nemoto, Naohisa Tsujino, Noriyuki Ohmuro, Kazunori Matsumoto, Hiroo Matsuoka, Kodai Tanaka, Shimako Nishiyama, Michio Suzuki, Hirohisa Kinoshita, Hiroki Ozawa, Hirokazu Fujita, Shinji Shimodera, Toshifumi Kishimoto, Kunichika Matsumoto, Tomonori Hasegawa, Masafumi Mizuno
    • Journal Title

      European Psychiatry

      Volume: 30 Issue: 8 Pages: 995-1001

    • DOI

      10.1016/j.eurpsy.2015.08.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differences between subjective experiences and observed behaviors in near-fatal suicide attempters with untreated schizophrenia: a qualitative pilot study.2015

    • Author(s)
      46.Taiju Yamaguchi, Chiyo Fujii, Takahiro Nemoto, Naohisa Tsujino, Kiyoaki Takeshi and Masafumi Mizuno
    • Journal Title

      Annals of General Psychiatry

      Volume: 14 Issue: 1 Pages: 17-17

    • DOI

      10.1186/s12991-015-0055-1

    • Related Report
      2015 Research-status Report
  • [Journal Article] A longitudinal study investigating sub-threshold symptoms and white matter changes in individuals with an 'at risk mental state' (ARMS).2015

    • Author(s)
      Katagiri N, Pantelis C, Nemoto T, Zalesky A, Hori M, Shimoji K, Saito J, Ito S, Dwyer DB, Fukunaga I, Morita K, Tsujino N, Yamaguchi T, Shiraga N, Aoki S, Mizuno M.
    • Journal Title

      Schizophr Res.

      Volume: 162 Issue: 1-3 Pages: 7-13

    • DOI

      10.1016/j.schres.2015.01.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] Mental health literacy and early intervention for youth generation.2018

    • Author(s)
      Mizuno M
    • Organizer
      WPA Thematic Congress 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Utilizing the Rorschach comprehensive system: Optimizing case formulation of cognitive-behavior therapy for Ultra-high risk of psychosis.2017

    • Author(s)
      Inoue N, Yorozuya Y, Tsujino N, Funatogawa T, Katagiri N, Nemoto T, Mizuno M
    • Organizer
      22nd International congress for the society of Rorschach and Projective methods.
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Implementing early intervention in Japan: challenges and opportunities.2016

    • Author(s)
      Mizuno M.
    • Organizer
      Global Round Table Meeting
    • Place of Presentation
      Hong Kong
    • Year and Date
      2016-12-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Rorschach data for ultra-high risk subjects who converted to psychosis.2016

    • Author(s)
      Naomi Inoue, Yuko Yorozuya, Naohisa Tsujino, Tomoyuki Funatogawa, Taijyu Yamaguti, Naoyuki Katagiri, Takahiro Nemoto, Masafumi Mizuno
    • Organizer
      IEPA 10th International Conference on Early Intervention in Mental Health
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2016-10-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] IEPA Presidential Note 20162016

    • Author(s)
      Mizuno M.
    • Organizer
      IEPA 10th International Conference on Early Intervention in Mental Health
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2016-10-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] The Early Intervention Service development in the real world. Today and its future possibilities.2016

    • Author(s)
      Mizuno M.
    • Organizer
      Convegno Nazionale Interventi Precoci in salute mentale.
    • Place of Presentation
      L'Aquila, Italy
    • Year and Date
      2016-05-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] State of the art of early psychosis in the world.2015

    • Author(s)
      Mizuno M
    • Organizer
      4th Giornata Scientifica AIPP(Associazione Italiana Interventi Precoci nelle Psicosi)
    • Place of Presentation
      Bari, Italy
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
  • [Book] 学術会議双書23 子どもの健康をはぐくむために 神尾陽子編集2017

    • Author(s)
      水野雅文
    • Total Pages
      304
    • Publisher
      日本学術協力財団
    • Related Report
      2016 Research-status Report
  • [Book] 今日の治療指針2016年度版2016

    • Author(s)
      水野雅文
    • Total Pages
      2192
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report
  • [Book] 外来で診る統合失調症2015

    • Author(s)
      水野雅文
    • Total Pages
      220
    • Publisher
      医学書院
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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