Development of fusion peptides of beta-hairpin peptides and survivin binding molecules as cancer-specific internal radiotherapeutic agents
| Project/Area Number |
15K09895
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUCHIGAMI Takeshi 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (30432206)
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| Co-Investigator(Kenkyū-buntansha) |
大庭 誠 長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (20396716)
吉田 さくら 長崎大学, 医歯薬学総合研究科(薬学系), 助教 (40736419)
中山 守雄 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (60164373)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 薬学 / 放射線 / 内用放射線療法 / 癌 / survivin / ペプチド / Survivin / がん |
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| Outline of Final Research Achievements |
In this study, we aimed to develop radiopharmaceuticals targeting survivin with the aim of developing internal radiotherapeutic agents that can be applied to nearly all cancers and show high selective effects on cancer tissues. Therefore, we designed survivin target peptides using cationic β-hairpin peptides (CHPs) as cancer cell carriers.
Within the research period, we succeeded in developing several peptides that bind to survivin with a completely new mechanism and found r9-INC-7c with stronger antitumor activity than reported a low molecular compound (S12). We also developed SVS-1 derivatives with high selectivity for cancer cells. In the future, we plan to develop fusion peptides of SVS-1 derivatives and survivin binding molecules as cancer-specific internal radiotherapeutic agents.
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Report
(4 results)
Research Products
(66 results)
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[Journal Article] Tofla virus: A newly identified Nairovirus of the Crimean-Congo hemorrhagic fever group isolated from ticks in Japan.2016
Author(s)
Shimada S, Aoki K, Nabeshima T, Fuxun Y, Kurosaki Y, Shiogama K, Onouchi T, Sakaguchi M, Fuchigami T, Ono H, Nishi K, Posadas-Herrera G, Uchida L, Takamatsu Y, Yasuda J, Tsutsumi Y, Fujita H, Morita K, Hayasaka D.
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Journal Title
Scientific Reports
Volume: 6
Issue: 1
Pages: 20213-20213
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Characterisation of radioiodinated flavonoid derivatives for SPECT imaging of cerebral prion deposits.2015
Author(s)
Fuchigami T, Yamashita Y, Kawasaki M, Ogawa A, Haratake M, Atarashi R, Sano K, Nakagaki T, Ubagai K, Ono M, Yoshida S, Nishida N, Nakayama M.
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Journal Title
Sci Rep.
Volume: 5
Issue: 1
Pages: 18440-18440
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 異常型プリオンの脳内沈着を可視化するための放射性ヨウ素標識ベンゾフラン誘導体の開発2016
Author(s)
川崎 仁央, 淵上 剛志, 中垣 岳大, 佐野 和憲, 新 竜一郎, 吉田 さくら, 小野 正博, 渡邊 裕之, 佐治 英郎, 西田 教行, 中山 守雄
Organizer
第56回日本核医学会学術総会
Place of Presentation
名古屋国際会議場（愛知県・名古屋市）
Year and Date
2016-11-03
Related Report
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[Presentation] 脳内異常型プリオン蛋白質を標的としたSPECTイメージング剤としてのフラボノイド関連化合物の開発2016
Author(s)
淵上剛志, 山下有紀, 川崎仁央, 原武衛, 新竜一郎, 佐野和憲, 中垣岳大, 祖母井香織, 小野正博, 吉田さくら, 西田教行, 中山守雄
Organizer
日本分子イメージング学会
Place of Presentation
神戸国際会議場（兵庫県・神戸市）
Year and Date
2016-05-28
Related Report
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[Presentation] 放射性ヨウ素標識ベンゾフラン誘導体の異常型プリオンイメージングプローブとしての評価2016
Author(s)
川崎 仁央, 淵上 剛志, 小山 隆介, 片山 史博, 中垣 岳大, 佐野 和憲, 新 竜一郎, 吉田 さくら, 原武 衛, 小野 正博, 渡邊 裕之, 佐治 英郎, 西田 教行, 中山 守雄
Organizer
第16回放射性医薬品・画像診断薬研究会
Place of Presentation
京都勧業館「みやこめっせ」(京都府・京都市）
Related Report
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