New Pulmonary MR Imaging with Ultra-Short TE for Morphological and Functional Evaluations

• Project/Area Number: 15K09923
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kobe University
• Principal Investigator: Ohno Yoshiharu 神戸大学, 医学研究科, 特命教授 (30324924)
• Co-Investigator(Kenkyū-buntansha): 西村 善博 神戸大学, 医学部附属病院, 特命教授 (20291453) ; 神山 久信 神戸大学, 医学研究科, 非常勤講師 (30546487) ; 吉川 武 神戸大学, 医学研究科, 特命講師 (40332788) ; 眞庭 謙昌 神戸大学, 医学研究科, 教授 (50362778) ; 杉村 和朗 神戸大学, 医学研究科, 教授 (00136384) ; 松本 純明 神戸大学, 医学研究科, 特命准教授 (60397833)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 放射線医学 / 生体情報

Outline of Final Research Achievements

This study was to determine the appropriate sequence for (1) morphological and (2) functional evaluations by pulmonary MR imaging with ultra-short TE (UTE-MRI), and develop the software in this setting. In addition, the newly developed UTE-MRI was directly compare the capability for pulmonary functional and morphological changes with other modalities in patients with pulmonary diseases.

Research Products

• [Int'l Joint Research] Heidelberg University(Germany)
• [Journal Article] Morphological Characterization of Pulmonary Nodules With Ultrashort TE MRI at 3T (2018)
  • Author(s): Wielputz Mark O.、Lee Ho Yun、Koyama Hisanobu、Yoshikawa Takeshi、Seki Shinichiro、Kishida Yuji、Sakai Yasuhiro、Kauczor Hans-Ulrich、Sugimura Kazuro、Ohno Yoshiharu
  • Journal Title: American Journal of Roentgenology Volume: 210 Issue: 6 Pages: 1-10
  • DOI: 10.2214/ajr.17.18961
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pulmonary high-resolution ultrashort TE MR imaging: Comparison with thin-section standard- and low-dose computed tomography for the assessment of pulmonary parenchyma diseases. (2016)
  • Author(s): Ohno Y, Koyama H, Yoshikawa T, Seki S, Takenaka D, Yui M, Lu A, Miyazaki M, Sugimura K.
  • Journal Title: J Magn Reson Imaging. Volume: ４３ Issue: 2 Pages: 512-32
  • DOI: 10.1002/jmri.25008
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Pulmonary Perfusion MR Imaging with Ultra-Short TE: Comparison of Capability for Regional Perfusion Assessment and Postoperative Lung Function Prediction with Perfusion SPECT and/ or Conventional CT Methods (2018)
  • Author(s): Yoshiharu Ohno, Masao Yui, Yu Chen, Yuji Kishida, Shinichiro Seki, Katsusuke Kyotani, Takeshi Yoshikawa.
  • Organizer: Joint Annual Meeting ISMRM-ESMRMB 2018
• [Presentation] Blood Volume-Based MRI with Ultra-Short TE: Capability for Prediction of Postoperative Lung Function in Non-Small Cell Lung Cancer Patients. (2017)
  • Author(s): Yoshiharu Ohno, Masao Yui, Yuji Kishida, Shinichiro Seki, Eiji Takeda, Katsusuke Kyotani, Yu Chen, Yoshimori Kassai, Takeshi Yoshikawa.
  • Organizer: 第45回日本磁気共鳴医学会大会
• [Presentation] Blood Volume-Based MR Imaging with Ultra-Short TE vs. Quantitatively and Qualitatively Assessed CT vs. Perfusion SPECT: Capability for Prediction of Postoperative Lung Function in Non-Small Cell Lung Cancer Patients. (2017)
  • Author(s): Yoshiharu Ohno, Masao Yui, Yu Chen, Shigeharu Ohyu, Yuji Kishida, Shinichiro Seki, Takeshi Yoshikawa, Katsusuke Kyotani, Hisashi Tachizaki.
  • Organizer: RSNA 2017 (103rd Scientific Assembly and Annual Meeting of Radiological Society of North America)
• [Presentation] Blood Volume-Based MR Imaging with Ultra-Short TE: Capability for Prediction of Postoperative Lung Function in NSCLC Patients as Compared with CT and Perfusion SPECT. (2017)
  • Author(s): Yoshiharu Ohno, Masao Yui, Yu Chen, Shigeharu Ohyu, Yuji Kishida, Shinichiro Seki, Takeshi Yoshikawa.
  • Organizer: ECR 2018 (30th Annual Meeting of European Congress of Radiology)
• [Presentation] Ultra-short TE Imaging at 3T for the Morphological Characterization of Pulmonary Nodules (2016)
  • Author(s): Wielptz MO, Lee HY, Ohno Y*, Yui M, Miyazaki M, Kishida Y, Seki S, Koyama H, Yoshikawa T, Kauczor HU, Sugimura K
  • Organizer: 102nd Scientific Assembly and Annual Meeting of Radiological Society of North America/ RSNA 2016
  • Place of Presentation: Chicago
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Pulmonary Thin-Section MRI with Ultra-Short TE: Capability for Lung Nodule Screening and Subtype Classification as Compared with Low- and Standard-Dose CTs (2016)
  • Author(s): Ohno Y, Kishida Y, Seki S, Koyama H, Yoshikawa T, Takenaka D, Yui M, Lu A, Miyazaki M, Kyotani K, Sugimura K
  • Organizer: 24th Scientific Meeting and Exhibition of International Society for Magnetic Resonance in Medicine/ ISMRM 2016
  • Place of Presentation: Shingapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Pulmonary Thin-Section MRI with Ultrashort TE: Capability for Lung Nodule Screening and Subtype Classification as Compared with Low- and Standard-Dose CTs (2016)
  • Author(s): Yoshiharu Ohno, Yuji Kishida, Shinichiro Seki, Hisanobu Koyama, Takeshi Yoshikawa, Daisuke Takenaka, Masao Yui, Aiming Lu, Mitsue Miyazaki, Kazuro Sugimura
  • Organizer: 24th Annual Meeting of International Society of Magnetic Resonance in Medicine/ ISMRM 2016
  • Place of Presentation: Singapore
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Pulmonary MR Imaging with Ultra-Short TE vs. Low- and Standard-Dose CTs: Capability for Lung Nodule Detection and Nodule Type Classification (2016)
  • Author(s): Ohno Y, Kishida Y, Seki S, Koyama H, Yoshikawa T, Takenaka D, Yui M, Lu A, Miyazaki M, Sugimura K
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-04-14
• [Presentation] Pulmonary thin-section MR imaging with ultra-short TE: comparison of capability for lung nodule detection and nodule type classification with low- and standard-dose thin-section CTs (2016)
  • Author(s): Yoshiharu Ohno, Yuji Kishida, Shinichiro Seki, Hisanobu Koyama, Takeshi Yoshikawa, Masao Yui, Aiming Lu, Mitsue Miyazaki, and Kazuro Sugimura
  • Organizer: European Congress of Radiology 2016
  • Place of Presentation: Vienna
  • Year and Date: 2016-03-02
  • Int'l Joint Research
• [Presentation] Pulmonary Thin-Section MR Imaging with Ultra-Short TE vs. Low- and Standard-Dose Thin-Section CTs: Capability for Lung Nodule Detection and Nodule Type Evaluation (2015)
  • Author(s): oshiharu Ohno, Shinichiro Seki, Hisanobu Koyama, Takeshi Yoshikawa, Sumiaki Matsumoto, Daisuke Takenaka, Masao Yui, Aiming Lu, Mitsue Miyazaki, Katsusuke Kyotani, Kazuro Sugimura
  • Organizer: 101st Scientific Assembly and Annual Meeting of Radiological Society of North America/ RSNA 2015
  • Place of Presentation: Chicago
  • Year and Date: 2015-11-29
  • Int'l Joint Research