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Analysis of medical reasons on reverse causation of leukemia and brain tumor following CT examination in children

Research Project

Project/Area Number 15K09934
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOita University of Nursing and Health Sciences

Principal Investigator

Kai Michiaki  大分県立看護科学大学, 看護学部, 教授 (10185697)

Co-Investigator(Kenkyū-buntansha) 小野 孝二  東京医療保健大学, 看護学部, 教授 (10611171)
Research Collaborator Ishiguchi Tsuneo  
Maeda Toru  
Yoshitake Takayasu  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsCT検査 / 放射線 / 線量 / 脳腫瘍 / がんリスク / 放射線量 / 被ばく / 検査理由 / 放射線リスク / 小児白血病 / 医療被ばく
Outline of Final Research Achievements

Recent studies suggest a causal link of childhood leukemia and brain tumor with repeated computed tomography (CT) scans. The reasons why frequent CT scans are taken in a specific child also remain unclear. A long-term follow-up retrospective study was conducted at a single institution. The medical reasons were classified for the examination of children under 16 years of age who underwent more than three CT scans into trauma, tumor, inflammation, and others. The frequencies of patients by reason were 23.3% for trauma, 5.3% for hydrocephalus, and 2.3% for appendicitis. The frequencies of trauma and inflammation decreased rapidly with an increasing number of CT scans. Hydrocephalus brought high frequency more than ten scans. The main medical reasons for frequent CT scans in children were trauma and hydrocephalus. Multiple follow-up CT scans in children with hydrocephalus would be traded off against the resultant increase in brain tumor risk associated with CT exposure.

Academic Significance and Societal Importance of the Research Achievements

医療におけるCT診断の利用は不可欠な技術である。しかし、他の放射線診断と比較して高い線量をもたらすために、近年CT診断に伴う放射線被ばくの健康リスクに対して国際的な関心が増大している。2012年のPearceらの研究結果は放射線被ばくが原因でリスクが増大したのか、それとも先天的なリスクをもつ小児にCT検査が多いのかという逆因果の関係にあるのかは明らかではないため国際的な争点となっている。本研究の結果は、逆因果の可能性をCT検査の理由を調査検討するだけでなく、小児CT検査回数が多いことは正当化されるのかを考えるためにも、小児CT検査回数がなぜ頻回となるのかを明らかにしたものである。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Presentation (4 results) (of which Int'l Joint Research: 1 results) Funded Workshop (1 results)

  • [Presentation] Analysis of examination reasons for multiple scans in paediatric CT in Japan2018

    • Author(s)
      Takayasu Yoshitake, Koji Ono, Osamu Miyazaki, Michiaki Kai
    • Organizer
      5th Asian and Oceanic Congress on Radiation Protection (AOCRP5)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 複数回CT検査を受けている小児の検査理由の分析2018

    • Author(s)
      吉武貴康、小野孝二、宮嵜修、甲斐倫明
    • Organizer
      日本保健物理学会第51回研究発表会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児頭部CT検査における臓器線量の推定2017

    • Author(s)
      吉武貴康、小野孝二、長谷川隆幸、勝沼泰、甲斐倫明
    • Organizer
      日本保健物理学会第50回発表会日本放射線安全管理学会第16回学術大会合同大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 複数回のCT検査を受けている小児の検査回数とその理由の分析2016

    • Author(s)
      吉武貴康、小野孝二、石口恒男、甲斐倫明
    • Organizer
      日本保健物理学会第49回研究発表会
    • Place of Presentation
      弘前文化センター
    • Year and Date
      2016-06-30
    • Related Report
      2016 Research-status Report
  • [Funded Workshop] 第14回放射線防護学会国際会議2016

    • Place of Presentation
      南アフリカ共和国、ケープタウン
    • Year and Date
      2016-05-09
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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