| Project/Area Number |
15K09950
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | University of Fukui |
|---|
Principal Investigator |
Mori Tetsuya 福井大学, 高エネルギー医学研究センター, 助教 (40397287)
|
|---|
| Research Collaborator |
KIYONO YASUSHI 福井大学, 高エネルギー医学研究センター, 教授 (50305603)
OKAZAWA HIDEHIKO 福井大学, 高エネルギー医学研究センター, 教授 (50360813)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 放射性薬剤 / PET / FFNP / PET薬剤 / 婦人科腫瘍 / プロゲステロンレセプター / 自動合成装置 / 分子イメージング |
|---|
| Outline of Final Research Achievements |
Progesterone receptor (PR) expression is an important factor to predict tumor responsiveness to hormonal therapy in gynecological oncology. The F-18 labeled fluoro furanyl norprogesterone ([F-18]FFNP) is a candidate for a PR imaging PET radiopharmaceutical, however, the reported method was difficult to adopt an automatic modules because of the complex reaction conditions. In this study, we developed an automatic synthesis for [F-18]FFNP using a plastic cassette-type automatic synthesizer system. The [F-18]FFNP synthesis was started from a mesylate precursor. F-18 fluoride was prepared by a small proton cyclotron, and the fluoride was purified by an ion exchange cartridge. Then the precursor was added to the reaction vial for the labelling. After that, the crude solution was purified by a preparative HPLC system. The radiochemical yields of the final product was 13%, and the radiochemical purity was >95%. The quality adapts for clinical research.
|
