Early diagnosis of dementia with Lewy bodies based on diagnostic imaging: pathologic-diagnostic imaging correlation

• Project/Area Number: 15K09957
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Tottori University
• Principal Investigator: Ogawa Toshihide 鳥取大学, 医学部, 教授 (00125709)
• Co-Investigator(Kenkyū-buntansha): 藤井 進也 鳥取大学, 医学部附属病院, 講師 (10379638) ; 篠原 祐樹 鳥取大学, 医学部附属病院, 助教 (60462470)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: レビー小体型認知症 / パーキンソン病 / 神経メラニンMRイメージング / ドーパミントランスポータイメージング / MIBG心筋シンチグラム / UPDRS III / MRI神経メラニンイメージング / ドパミントランスポータ画像 / 心交感神経機能画像

Outline of Final Research Achievements

We propose a diagnostic approach for dementia with Lewy bodies (DLB) and its related neurodegenerative diseases using MR imaging and SPECT. First, conventional MR imaging and neuromelanin sensitive MR imaging should be applied to the patients with movement disorders and/or dementia. Second, MIBG myocardial scintigraphy should be selected according to these MR imaging findings. Moreover, a combination of these neuroimaging methods including SPECT with 123I-FP-CIT is a useful and practical approach for the differential diagnosis and confirmation of DLB and its related neurodegenerative diseases.

Research Products

• [Journal Article] A Case of Intracranial Subependymoma: Histopathological Confirmation of Ring-shaped Lateral Ventricular Nodule (2018)
  • Author(s): Kuya K, Shinohara Y, Yoshioka H, Kuwamoto S, Kurosaki M, Ogawa T.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 2 Pages: 105-106
  • DOI: 10.2463/mrms.ci.2017-0025
  • NAID: 130006685593
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Evaluation of Parkinson’s disease by neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT (2018)
  • Author(s): Kuya K, Ogawa T, Fujii S, Shinohara Y, Miyosh F, Ishibashi M, Mukuda N, Tanabe
  • Journal Title: Acta Radiologica Volume: 59 Issue: 5 Pages: 593-598
  • DOI: 10.1177/0284185117722812
  • Peer Reviewed
• [Journal Article] Use of high b value diffusion-weighted magnetic resonance imaging in acute encephalopathy/ encephalitis during childhood (2018)
  • Author(s): Tsubouchi Y, Itamura S, Saito Y, Yamashita E, Shinohara Y, Okazaki T, Ohno K, Nishimura Y, Oguri M, Maegaki Y.
  • Journal Title: Brain Dev Volume: 40 Issue: 2 Pages: 116-125
  • DOI: 10.1016/j.braindev.2017.07.012
  • Peer Reviewed
• [Journal Article] Superficial siderosis associated with a pineal cavernous malformation. (2018)
  • Author(s): Ogura T, Kambe A, Sakamoto M, Shinohara Y, Ogawa T, Kurosaki M
  • Journal Title: World Neurosurg Volume: 109 Pages: 230-232
  • DOI: 10.1016/j.wneu.2017.09.197
  • Peer Reviewed
• [Journal Article] Utility of intravoxel incoherent motion MR imaging and arterial spin labeling for recurrent glioma after bevacizumab treatment. (2018)
  • Author(s): Miyoshi F, Shinohara Y, Kambe A, Kuya K, Murakami A, Kurosaki M, Ogawa T.
  • Journal Title: Acta Radiol Volume: 印刷中 Issue: 11 Pages: 1372-1379
  • DOI: 10.1177/0284185118759707
  • Peer Reviewed
• [Journal Article] 認知症の画像診断 (2018)
  • Author(s): 岡沢秀彦，小川敏英
  • Journal Title: 臨放 Volume: 63 Pages: 127-129
• [Journal Article] 認知症と画像診断 -認知症の画像診断の役割と将来展望- (2018)
  • Author(s): 小川敏英
  • Journal Title: Rad fan Volume: 16 Pages: 57-57
• [Journal Article] Differentiating parotid tumors by quantitative signal intensity evaluation on MR imaging (2017)
  • Author(s): Matsusue E, Fujihara Y, Matsuda E, Tokuyasu Y, Nakamoto S, Nakamura K, Ogawa T.
  • Journal Title: Clin Imaging Volume: 46 Pages: 37-43
  • DOI: 10.1016/j.clinimag.2017.06.009
  • Peer Reviewed
• [Journal Article] Evaluation of Fetal Thyroid with 3D Gradient Echo T₁-weighted MR Imaging (2017)
  • Author(s): Fujii S, Nagaishi J, Mukuda N, Kaneda S, Inoue C, Fukunaga T, Ogawa T.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 16 Issue: 3 Pages: 203-208
  • DOI: 10.2463/mrms.mp.2015-0157
  • NAID: 130005797414
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed
• [Journal Article] Utility of high-resolution 3D multi-sequences for peripheral facial palsy: differentiation between Bell's palsy and Ramsay Hunt syndrome (2017)
  • Author(s): Kuya J, Kuya K, Shinohara Y, Kunimoto Y, Yazama H, Ogawa T, Takeuchi H.
  • Journal Title: Otol Neurotol Volume: 38 Issue: 10 Pages: 1523-1527
  • DOI: 10.1097/mao.0000000000001605
  • Peer Reviewed
• [Journal Article] Proximal bright vessel sign on arterial spin labeling magnetic resonance imaging in acute cardioembolic cerebral infarction (2017)
  • Author(s): Kato A, Shinohara Y, Kuya K, Sakamoto M, Kowa H, Ogawa T.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: - Issue: 7 Pages: 1457-1461
  • DOI: 10.1016/j.jstrokecerebrovasdis.2017.03.015
  • Peer Reviewed
• [Journal Article] A case of acute encephalopathy with biphasic seizures and late reduced diffusion: utility of arterial spin labeling sequence in prognosis prediction of febrile status epilepticus (2017)
  • Author(s): Kuya K, Fujii S, Miyoshi F, Ohno K, Shinohara Y, Maegaki Y, Ogawa T.
  • Journal Title: Brain Dev Volume: 39 Issue: 1 Pages: 84-8
  • DOI: 10.1016/j.braindev.2016.07.003
  • Peer Reviewed
• [Journal Article] Reduction of metal artifacts due to dental hardware in computed tomography angiography: assessment of the utility of model-based iterative reconstruction (2017)
  • Author(s): Kuya K, Shinohara Y, Kato A, Sakamoto M, Kurosaki M, Ogawa T.
  • Journal Title: Neuroradiology Volume: - Issue: 3 Pages: 231-235
  • DOI: 10.1007/s00234-017-1811-5
  • Peer Reviewed
• [Journal Article] Carotid plaque evaluation using gemstone spectral imaging: comparison with magnetic resonance angiography (2017)
  • Author(s): Shinohara Y, Sakamoto M, Kuya K, Kishimoto J, Yamashita E, Fujii S, Kurosaki M, Ogawa T.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: - Issue: 7 Pages: 1535-1540
  • DOI: 10.1016/j.jstrokecerebrovasdis.2017.02.036
  • Peer Reviewed
• [Journal Article] Significance of combined use of MRI and perfusion SPECT for evaluation of multiple system atrophy, cerebellar type (2016)
  • Author(s): Miyoshi F, Kanasaki Y, Shinohara Y, Fujii S, Kaminou T, Tanabe Y, Ogawa T.
  • Journal Title: Acta Radiol Volume: 57 Issue: 6 Pages: 742-749
  • DOI: 10.1177/0284185115598810
  • Peer Reviewed
• [Journal Article] Correlation between neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT in patients with parkinsonism (2016)
  • Author(s): Kuya K, Shinohara Y, Miyoshi F, Fujii S, Tanabe Y, Ogawa T.
  • Journal Title: Neuroradiology Volume: 58 Issue: 4 Pages: 351-356
  • DOI: 10.1007/s00234-016-1644-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Diagnosis of dementia with Lewy bodies using neuroimaging -differential diagnoses and diagnostic approach- (2017)
  • Author(s): Toshihide Ogawa, Keita Kuya, Shinichiro Kitao, Yuki Shinohara, Aguni Kato, Mana Ishibashi, Yoshio Tanabe, Shinya Fujii
  • Organizer: 第40回ヨーロッパ神経放射線学会 マルメ（スウェーデン）
  • Int'l Joint Research
• [Presentation] Important imaging findings easily overlooked on brain CT and MR imaging (2017)
  • Author(s): Toshihide Ogawa, Yuki Shinohara, Shinya Fujii
  • Organizer: 第103回北米放射線学会 シカゴ（米国）
  • Int'l Joint Research
• [Presentation] Role of neuroimaging on differentiation of Parkinson’s disease and its related neurodegenerative diseases (2016)
  • Author(s): Ogawa T, Kitao S, Kuya K, Miyoshi F, Shinohara Y, Fujii S, Ishibashi M, Tanabe Y
  • Organizer: 第102回北米放射線学会
  • Place of Presentation: Chicago McCormick Place (USA)
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Evaluation of Parkinson’s disease by neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT (2016)
  • Author(s): Ogawa T, Kuya K, Shinohara Y, Miyoshi F, Fujii S, Ishibashi M, Tanabe Y
  • Organizer: 第29回ヨーロッパ核医学会
  • Place of Presentation: Barcelona International Convention Center (Spain)
  • Year and Date: 2016-10-15
  • Int'l Joint Research
• [Presentation] パーキンソン病患者における 123I-FP-CIT SPECTと神経メラニンMRIとの相関性の検討 (2016)
  • Author(s): 久家圭太、篠原祐樹、三好史倫 石橋 愛、藤井進也、田邉芳雄、小川敏英
  • Organizer: 第51回日本核医学会中国・四国地方会
  • Place of Presentation: 広島県医師会館ホール（広島県広島市）
  • Year and Date: 2016-06-17
• [Presentation] パーキンソン症候群患者における神経メラニンMRIと123I-FP-CIT SPECTの相関性の検討 (2016)
  • Author(s): 久家圭太、篠原祐樹、三好史倫、藤井進也、田邉芳雄、小川敏英
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（ 神奈川県，横浜市）
  • Year and Date: 2016-04-14
• [Presentation] Correlation between neuromelanin-sensitive MR imaging and 123I-FP-CIT SPECT in patients with Parkinson disorder (2015)
  • Author(s): Kuya K, Shinohara Y, Miyoshi F, Fujii S, Tanabe Y, Ogawa T.
  • Organizer: 10th Asian Oceanian Congress of Neuroradiology
  • Place of Presentation: Hilton Fukuoka Sea Hawk（ 福岡県，福岡市）
  • Year and Date: 2015-11-05
  • Int'l Joint Research