Multilateral approach toward realization of next generation boron neutron capture therapy
| Project/Area Number |
15K09986
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
増永 慎一郎 京都大学, 原子炉実験所, 教授 (80238914)
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| Co-Investigator(Renkei-kenkyūsha) |
KUMADA Hiroaki 筑波大学, 医学医療系, 准教授 (30354913)
FUKUMISTU Nobuyoshi 筑波大学, 医学医療系, 准教授 (40277075)
SAKURAI Yoshinori 京都大学複合原子力化学研究所, 放射線生命科学研究部門, 准教授 (20273534)
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| Research Collaborator |
HATTORI Kenjiro
SAKURAI Hideyuki
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | BNCT / DDS / Folate receptor / Cyclodextrin / high LET / ホウ素中性子捕捉療法 / 葉酸受容体 / シクロデキストリン / 粒子線治療 / ホウ素化合物 / radiation / BSH / BPA / 葉酸 |
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| Outline of Final Research Achievements |
The stability constants Kc was 1.4×104 (/ M) in BSH and the value suggests that ND201 and BSH shows stable complex in culture medium and human blood. The stoichiometry of a host-guest complex was determined by the continuous variation plot method. The plots made by monitoring the fluorescence intensity change gave a maximum peak at 0.5, indicating that ND201 forms an inclusion complex with BSH at a 1:1 molar ratio. Next, the boron concentration in tumors and blood was measured by ICP-MS. The concentration in blood showed similar time course kinetics after BSH and BSH-ND201 without depending on the tumor type. On the other hand, the concentration in tumor showed drastic decrease immediately after BSH administration, whereas it increased to 24 hours and showed high value at 72 hours after BSH-ND201 administration. The T/B ratio when the intratumoral boron concentration was peak was calculated and BSH-ND201 showed high T/B ratio (10.6) for Colon-26 tumor.
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Determination of the relative biological effectiveness and oxygen enhancement ratio for micronuclei formation using high-LET radiation in solid tumor cells: An in vitro and in vivo study2015
Author(s)
Ryoichi Hirayama, Akiko Uzawa, Maki Obara, Nobuhiro Takase, Kana Koda, Masakuni Ozaki, Miho Noguchi, Yoshitaka Matsumoto, Huizi Li, Kei Yamashita, Sachiko Koike, Koichi Ando, Toshiyuki Shirai, Naruhiro Matsufuji and Yoshiya Furusawa
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Journal Title
Mutation Research
Volume: 793
Pages: 41-47
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] In vivo radiobiological assessment of the new clinical carbon ion beams at CNAO.2015
Author(s)
Angelica Facoetti, Barbara Vischioni, Mario Ciocca, Michele Ferrarini, Yohsiya Furusawa, Andrea Mairani, Yoshitaka Matsumoto, Alfredo Mirandola, Silvia Molinelli, Akiko Uzawa, Freixas G. Vilches and Roberto Orecchia
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Journal Title
Radiation Protection Dosimetry
Volume: 166
Issue: 1-4
Pages: 379-382
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] RhoA correlates clinical outcomes of the chemoradiotherapy for StageIII cervical cancer2016
Author(s)
Keiichi Tanaka, Hitoshi Ishikawa, Yoshitaka Matsumoto, Haruko Numajiri, Takashi Saito, Reiko Kanuma, Yoshiko Oshiro, Toshiyuki Okumura, Todomi Stach and Hideyuki Sakurai
Organizer
29th Annual Meeting of JASTRO
Place of Presentation
国立京都国際会館, 京都, 京都
Year and Date
2016-11-25
Related Report
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[Presentation] The effect of uneven fractionation using high LET carbon-ion beams for tumor metastatic abilities2016
Author(s)
Yoshitaka Matsumoto, Ryoichi Hirayama, Akiko Uzawa, Huizi Li, Kei Yamashita, Yumiko Kaneko, Koji Tsuboi, Toshiyuki Shirai, Koichi Ando, Yoshiya Furusawa and Hideyuki Sakurai
Organizer
PTCOG 55
Place of Presentation
Prague, Czech
Year and Date
2016-05-23
Related Report
Int'l Joint Research
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[Presentation] The usefulness of heavy-ion beam to the radioresistance and the metastatic potential enhanced by cyclic hypoxia condition.2015
Author(s)
Yoshitaka Matsumoto, Kei Yamashita, Huizu Li, Yumiko Kaneko, Lue Sun, Takeshi Moritake, Akiko Uzawa, Ryoichi Hirayama, Koichi Ando, Shinichiro Masunaga, Toshiyuki Shirai, Yoshiya Furusawa, Hideyuki Sakurai
Organizer
15th International Congress of Radiation Research
Place of Presentation
Kyoto International Conference Center, Kyoto
Year and Date
2015-05-27
Related Report
Int'l Joint Research
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