Chronic inflammation and sarcopenia in radiotherapy for cancer: novel prognosticators over chronological age

• Project/Area Number: 15K09992
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: Matsuo Yukinori 京都大学, 医学研究科, 准教授 (80456897)
• Co-Investigator(Kenkyū-buntansha): 中村 晶 京都大学, 医学研究科, 助教 (40708591)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: サルコペニア / 慢性炎症 / 放射線治療 / がん治療 / 肺癌 / 燃え尽き症候群

Outline of Final Research Achievements

We evaluated relationship of chronic inflammation and sarcopenia with survival outcomes after radiotherapy for cancer. In patients treated with stereotactic body radiotherapy for early stage lung cancer, chronic inflammation and sarcopenia were respectively associated with lung cancer death and non-lung cancer death. Patients with locally-advanced lung cancer with chronic inflammation and lower body mass index had poorer prognosis. The results suggested that chronic inflammation and sarcopenia can be novel prognosticators over chronological age or tumor stage.

Research Products

• [Journal Article] A Retrospective Long-term Follow-up Study of Stereotactic Body Radiation Therapy for Non-Small Cell Lung Cancer From a Single Institution: Incidence of Late Local Recurrence (2018)
  • Author(s): Shintani Takashi、Matsuo Yukinori、Iizuka Yusuke、Mitsuyoshi Takamasa、Mizowaki Takashi
  • Journal Title: International Journal of Radiation Oncology*Biology*Physics Volume: 100 Issue: 5 Pages: 1228-1236
  • DOI: 10.1016/j.ijrobp.2018.01.050
  • Peer Reviewed
• [Journal Article] Pilot Study of the Safety and Efficacy of Dose Escalation in Stereotactic Body Radiotherapy for Peripheral Lung Tumors (2018)
  • Author(s): Mitsuyoshi Takamasa、Matsuo Yukinori、Shintani Takashi、Iizuka Yusuke、Ueki Nami、Nakamura Mitsuhiro、Mizowaki Takashi
  • Journal Title: Clinical Lung Cancer Volume: 19 Issue: 3 Pages: e287-e296
  • DOI: 10.1016/j.cllc.2017.11.008
  • Peer Reviewed
• [Journal Article] Evaluation of a prognostic scoring system based on the systemic inflammatory and nutritional status of patients with locally advanced non-small-cell lung cancer treated with chemoradiotherapy (2017)
  • Author(s): Mitsuyoshi Takamasa、Matsuo Yukinori、Itou Hitoshi、Shintani Takashi、Iizuka Yusuke、Kim Young Hak、Mizowaki Takashi
  • Journal Title: Journal of Radiation Research Volume: 59 Issue: 1 Pages: 50-57
  • DOI: 10.1093/jrr/rrx060
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Significance of Serum CEA for Non-small Cell Lung Cancer Patients Receiving Stereotactic Body Radiotherapy (2017)
  • Author(s): 1. Shintani T, Matsuo Y, Iizuka Y, Mitsuyoshi T, Mizowaki T, Hiraoka M.
  • Journal Title: Anticancer Research Volume: 37 Issue: 9 Pages: 5161-5167
  • DOI: 10.21873/anticanres.11937
  • Peer Reviewed
• [Journal Article] Evaluation of the prevalence of burnout and psychological morbidity among radiation oncologist members of the Kyoto Radiation Oncology Study Group (KROSG) (2017)
  • Author(s): Mampuya Wambaka Ange、Matsuo Yukinori、Nakamura Akira、Hiraoka Masahiro
  • Journal Title: Journal of Radiation Research Volume: 58 Issue: 2 Pages: 217-224
  • DOI: 10.1093/jrr/rrw094
  • Peer Reviewed / Open Access
• [Journal Article] Pretreatment modified Glasgow Prognostic Score predicts clinical outcomes after stereotactic body radiotherapy for early-stage non-small cell lung cancer. (2015)
  • Author(s): Kishi T, Matsuo Y, Ueki N, Iizuka Y, Nakamura A, Sakanaka K, Mizowaki T, Hiraoka M.
  • Journal Title: Int J Radiat Oncol Biol Phys: Volume: in press Issue: 3 Pages: 619-26
  • DOI: 10.1016/j.ijrobp.2015.02.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pretreatment C-reactive protein level predicts outcome and patterns of failure after chemoradiotherapy for locally advanced pancreatic cancer. (2015)
  • Author(s): Kishi T, Nakamura A, Itasaka S, Shibuya K, Matsumoto S, Kanai M, Kodama Y, Takaori K, Mizowaki T, Hiraoka M
  • Journal Title: Pancreatology Volume: 15 Issue: 6 Pages: 694-700
  • DOI: 10.1016/j.pan.2015.09.016
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 松尾 幸憲, 陳 豊史, 濱路 政嗣, 光吉 隆真, 新谷 尭, 飯塚 裕介, 園部 誠, 伊達 洋至 (2017)
  • Author(s): 葉切除高リスク患者のI期非小細胞肺癌に対する体幹部定位放射線治療と縮小手術の治療成績：第２報
  • Organizer: 日本肺癌学会
• [Presentation] Updated Results of Propensity-based Analysis of Stereotactic Body Radiotherapy and Sublobar Resection for Stage I Non-small Cell Lung Cancer in Patients at High Risk for Lobectomy (2017)
  • Author(s): Yukinori Matsuo
  • Organizer: ASTRO2017
  • Int'l Joint Research
• [Presentation] OA 01.08 - Discussant (2017)
  • Author(s): Yukinori Matsuo
  • Organizer: 世界肺癌会議
  • Int'l Joint Research / Invited
• [Presentation] Impact of Inflammation and Sarcopenia on Outcomes after Stereotactic Body Radiotherapy for T1N0M0 Non-Small Cell Lung Cancer (2016)
  • Author(s): Matsuo Y, Nagata Y, Wakabayashi M, Eba J, Ishikura S, Onishi H, Kokubo M, Karasawa K, Shioyama Y, Onimaru R, Hiraoka M
  • Organizer: IASLC 17th World Conference on Lung Cancer
  • Place of Presentation: Messe Wien Exhibition & Congress Center, Vienna, Austria
  • Year and Date: 2016-12-04
  • Int'l Joint Research
• [Presentation] Evaluation of the prevalence of burnout among Japanese radiation oncologists in the KROSG (2016)
  • Author(s): Matsuo Y, Mampuya WA
  • Organizer: 第29回日本放射線腫瘍学会学術大会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2016-11-25
• [Presentation] Impact of low skeletal muscle mass on survival after SBRT for non-small cell lung cancer. (2016)
  • Author(s): Matsuo Y, Mitsuyoshi T, Nakamura A, Iizuka Y, Kishi T, Mampuya AW, Hanazawa H, Hiraoka M
  • Organizer: ESTRO 35
  • Place of Presentation: トリノ、イタリア
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] Impact of low skeletal muscle mass on survival after SBRT for non-small cell lung cancer (2016)
  • Author(s): Y Matsuo T Mitsuyoshi A Nakamura Y Iizuka T Kishi W Mampuya H Hanazawa M Hiraoka
  • Organizer: ESTRO35
  • Place of Presentation: トリノ、イタリア
  • Year and Date: 2016-04-29
  • Int'l Joint Research