Diagnostic approach to breast cancer patients based on target metabolomics in saliva

Research Project

Project/Area Number	15K10060
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	General surgery
Research Institution	Nagoya City University
Principal Investigator	Toyama Tatsuya 名古屋市立大学, 大学院医学研究科, 教授 (30315882)
Co-Investigator(Kenkyū-buntansha)	豊岡利正静岡県立大学, 薬学部, 特任教授 (40183496) 吉本信保名古屋市立大学, 大学院医学研究科, 研究員 (10551244) 遠藤友美名古屋市立大学, 大学院医学研究科, 講師 (20566228)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	乳癌 / ポリアミン
Outline of Final Research Achievements	Eight polyamines strongly correlated with the cancer patients. A simple 1-order equation was developed for the discrimination of the breast cancer patients and healthy persons. The concordance rate of the breast cancer patients and the healthy persons by the equation was 88% and 76% on the training set, respectively, whereas those on the validation set was both 88%. The score in the equation tended to correlate with the cancer stage of the patients and increased with the more serious conditions.