Clinical Significance and elucidation of molecular regulation mechanism of lipid mediators in invasion and metastatic ability of gastric cancer

• Project/Area Number: 15K10087
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Niigata University
• Principal Investigator: Hanyu Takaaki 新潟大学, 医歯学総合病院, 助教 (50719705)
• Co-Investigator(Kenkyū-buntansha): 永橋 昌幸 新潟大学, 医歯学総合病院, 講師 (30743918) ; 若井 俊文 新潟大学, 医歯学系, 教授 (50372470) ; 石川 卓 新潟大学, 医歯学総合病院, 准教授 (70586940) ; 小杉 伸一 新潟大学, 医歯学総合病院, 特任教授 (90401736) ; 小林 隆 新潟大学, 医歯学総合病院, 講師 (40464010)
• Research Collaborator: TAKABE Kazuaki ; Sarah Spiegel
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 胃癌 / 脂質メディエーター / スフィンゴシン-1-リン酸 / スフィンゴシンキナーゼ / リンパ節転移 / スフィンゴシンキナーゼ1型 / リンパ管新生 / リピドミクス解析 / スフィンゴシンキナーゼ１型

Outline of Final Research Achievements

We hypothesized that sphingosine kinase type 1 (SphK1) and sphingosine-1-phosphate (S1P) is associated with the progression of human gastric cancer and lymphatic invasion. To test this hypothesis, we analyzed relationship between SphK1, S1P, clinicopathological features, and prognosis in human gastric cancer by immunohistochemistry and mass spectrometry.
SphK1 expression was correlated with gastric cancer progression, especially diffuse infiltrative type and lymphatic invasion, and furthermore in survival rate SphK1 positive group was poor prognosis as compared with negative group. pSphK1 expression significantly associated with S1P levels in the gastric cancer tissue.
We reported that SphKl and S1P play an important role in the progression of human gastric cancer.

Research Products

• [Journal Article] Expression of phosphorylated sphingosine kinase 1 is associated with diffuse type and lymphatic invasion in human gastric cancer. (2018)
  • Author(s): Hanyu T, Nagahashi M, Ichikawa H, Ishikawa T, Kobayashi T, Wakai T.
  • Journal Title: Surgery Volume: [Epub ahead of print] Issue: 6 Pages: 1301-1306
  • DOI: 10.1016/j.surg.2017.11.024
  • Peer Reviewed / Int'l Joint Research
• [Presentation] リン酸化スフィンゴシンキナーゼ1の発言と胃癌の進行についての関連 (2018)
  • Author(s): 羽入隆晃, 永橋昌幸, 市川寛, 石川卓, 角田知行, 須藤翔, 根本万理子, 小杉伸一, 島田能史, 坂田純, 小林隆, 亀山仁史, 若井俊文
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] Expression of phosphorylated sphingosine kinase 1 is associated with invasiveness of gastric cancer (2017)
  • Author(s): Takaaki Hanyu, Masayuki Nagahashi, Hiroshi Ichikawa, Takashi Ishikawa, Shin-ichi Kosugi, Masato Nakajima, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Toshifumi Wakai
  • Organizer: The 12th Annual Academic Surgical Congress
  • Place of Presentation: Las Vegas（USA）
  • Year and Date: 2017-02-07
  • Int'l Joint Research
• [Presentation] Expression of phosphorylated sphingosine kinase 1 is associated with invasiveness of gastric cancer (2017)
  • Author(s): Takaaki Hanyu, Masayuki Nagahashi, Hiroshi Ichikawa, Takashi Ishikawa, Shin-ichi Kosugi, Masato Nakajima, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Toshifumi Wakai
  • Organizer: The 12th Annual Academic Surgical Congress（国際学会）
  • Int'l Joint Research
• [Presentation] Expression of phosphorylated sphingosine kinase 1 is associated with invasiveness of human gastric cancer (2017)
  • Author(s): Takaaki Hanyu, Masayuki Nagahashi, Hiroshi Ichikawa, Takashi Ishikawa, Shin-ichi Kosugi, Masato Nakajima, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Toshifumi Wakai
  • Organizer: 第89回日本胃癌学会総会