| Project/Area Number |
15K10092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
FUKAYA MASAHIDE 名古屋大学, 医学部附属病院, 病院講師 (10420382)
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| Co-Investigator(Kenkyū-buntansha) |
山口 淳平 名古屋大学, 医学部附属病院, 助教 (00566987)
梛野 正人 名古屋大学, 医学系研究科, 教授 (20237564)
國料 俊男 名古屋大学, 医学部附属病院, 病院講師 (60378023)
横山 幸浩 名古屋大学, 医学部附属病院, 講師 (80378091)
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| Research Collaborator |
KITAGAWA TOMOMI
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | RAGE / 術後感染症 |
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| Outline of Final Research Achievements |
Severe liver damage was identified in rats with bile duct ligation and liver ischemia re-perfusion. RAGE (Receptor for advanced glycation end products) was highly expressed in these rats. TAK242, a TLR4 inhibitor, suppressed the elevation of serum ALT and AST in the rats with bile duct ligation and liver ischemia re-perfusion. In addition, TAK242 treatment decreased the area of hepatic necrosis and suppressed the expression of IL-1β, IL-6 and HMGB1. TAK242 significantly improved the severity of the liver damage caused by bile duct ligation and liver ischemia re-perfusion. However, the compound was not able to significantly suppress RAGE expression. In addition, bisabolol did not demonstrate an inhibitory effect against RAGE in rats with bile duct ligation and liver ischemia re-perfusion. Further investigations will be required for clinical applications. However, this study suggests that novel therapies using TAK242 for treating severe liver damage could be efficacious.
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