| Project/Area Number |
15K10107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
OKUMURA Hiroshi 鹿児島大学, 医歯学総合研究科, 客員研究員 (10398282)
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| Co-Investigator(Kenkyū-buntansha) |
盛 真一郎 鹿児島大学, 医歯学域附属病院, 助教 (00620519)
内門 泰斗 鹿児島大学, 医歯学域附属病院, 特任准教授 (30464465)
喜多 芳昭 鹿児島大学, 医学部・歯学部附属病院, その他(移行) (30570692)
夏越 祥次 鹿児島大学, 医歯学域医学系, 教授 (70237577)
石神 純也 鹿児島大学, 医歯学総合研究科, 客員研究員 (90325803)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 消化器癌 / 化学放射線療法 / 化学療法 / 幹細胞 / 活性酸素 |
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| Outline of Final Research Achievements |
While chemoradiation therapy is one of the most useful treatments for esophageal squamous cell carcinoma (ESCC), it is important to predict response before treatment by using markers. Fifty-nine patients with ESCC were treated with neoadjuvant chemoradiation therapy. The expression of seven kinds of biomarker candidate proteins (P53，CDC25B，14-3-3sigma，P53R2，ERCC１，Gli1，Nrf2) in biopsy specimens of untreated primary tumor was evaluated whether it correlates with the response and prognosis.
CRT was significantly effective in p53 (-), p53R2 (-), and ERCC1 (-) tumors and p53 (-), p53R2 (-) and ERCC1 (-) were independent correlated factors for effective histological response. Their combined expression of three or two negative expressions had 100% effective response, and was significant prognostic factor. Our results suggest that three or two negative expressions of p53, p53R2, ERCC1 in biopsy specimens of primary tumors were associated with a favorable response to CRT for ESCC.
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