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Depleted tumor suppressor microRNAs in body fluid contribute to poor outcomes and are novel therapeutic targets in digestive system cancers

Research Project

Project/Area Number 15K10112
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Komatsu Shuhei  京都府立医科大学, 医学(系)研究科(研究院), 特任講師 (40578978)

Co-Investigator(Kenkyū-buntansha) 大辻 英吾  京都府立医科大学, 医学(系)研究科(研究院), 教授 (20244600)
市川 大輔  山梨大学, 大学院総合研究部, 教授 (20347446)
Research Collaborator Miyamae Mahito  京都府立医大学, 医学研究科
Okajima Wataru  京都府立医大学, 医学研究科
Ohashi Takuma  京都府立医大学, 医学研究科
Imamura Taisuke  京都府立医大学, 医学研究科
Kiuchi Jun  京都府立医大学, 医学研究科
Nishibeppu Keji  京都府立医大学, 医学研究科
Taniguchi Hiroki  京都第二赤十字病院
Todo Momoko  京都第二赤十字病院
Kondo Yutaka  京都第二赤十字病院
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsリキッドバイオプシー / microRNA / バイオマーカー / 遊離核酸 / エキソソーム / 核酸治療
Outline of Final Research Achievements

The development of minimally invasive biomarkers in body fluids, so-called 'liquid biopsy' have been required. Since the first report in gastric cancer in 2010, we have identified more than 20 candidate microRNAs for liquid biopsy in plasma of patients with digestive tract cancers, which could be useful in early cancer detection, monitoring disease status, and predicting malignant potential, prognosis and treatment sensitivity. During these processes, we also indentified that a low level of some tumor suppressor microRNAs in plasma relates to tumor progression and poor outcomes of esophageal cancer in miR-375 (Expert Opin Biol Ther 2012) and miR-655 (In press 2018), pancreatic cancer in miR-107 (Sci Rep 2017), and gastric cancer in miR-101 (Oncotarget 2017) and miR-148a (In press 2018). Moreover, we demonstrated that the restoration and maintenance of these plasma microRNA levels may be a novel therapy for inhibiting tumor and metastatic progression in the in vivo analyses using mice.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015

All Journal Article (15 results) (of which Peer Reviewed: 15 results,  Open Access: 8 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results)

  • [Journal Article] Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma2018

    • Author(s)
      Imamura T, Komatsu S et al.
    • Journal Title

      Carcinogenesis

      Volume: 39 Issue: 2 Pages: 263-271

    • DOI

      10.1093/carcin/bgx139

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer2017

    • Author(s)
      Imamura T, Komatsu S et al.
    • Journal Title

      Sci Rep

      Volume: 7 Issue: 1 Pages: 5708-5708

    • DOI

      10.1038/s41598-017-06137-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low plasma levels of miR-101 are associated with tumor progression in gastric2017

    • Author(s)
      Imamura T, Komatsu S et al.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 63 Pages: 106538-106550

    • DOI

      10.18632/oncotarget.20860

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Liquid biopsy in patients with hepatocellular carcinoma: Circulating tumor cells and cell-free nucleic acids2017

    • Author(s)
      Okajima W, Komatsu Set al.
    • Journal Title

      World J Gastroenterol

      Volume: 21 Issue: 31 Pages: 5650-5668

    • DOI

      10.3748/wjg.v23.i31.5650

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of CTEN relates to tumor malignant potential and poor outcomes of adenocarcinoma of the esophagogastric junction2017

    • Author(s)
      Aratani K, Komatsu S et al.
    • Journal Title

      Oncotarget

      Volume: 8 Issue: 48 Pages: 84112-84122

    • DOI

      10.18632/oncotarget.21109

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma.2017

    • Author(s)
      Ohashi T, Komatsu S et al.
    • Journal Title

      Br J Cancer

      Volume: 116 Issue: 2 Pages: 218-226

    • DOI

      10.1038/bjc.2016.394

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma microRNA profiles: identification of miR-23a as a novel biomarker for chemoresistance in esophageal squamous cell carcinoma.2016

    • Author(s)
      Komatsu S et al.
    • Journal Title

      Oncotarget

      Volume: 7 Pages: 62034-62048

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating microRNA profiles in plasma: identification of miR-224 as a novel diagnostic biomarker in hepatocellular carcinoma independent of hepatic function.2016

    • Author(s)
      Okajima W, Komatsu S et al.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 33 Pages: 53820-53836

    • DOI

      10.18632/oncotarget.10781

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating MicroRNAs: A Next-Generation Clinical Biomarker for Digestive System Cancers.2016

    • Author(s)
      Kawaguchi T, Komatsu S et al.
    • Journal Title

      Int J Mol Sci.

      Volume: 17 Issue: 9 Pages: 1459-1459

    • DOI

      10.3390/ijms17091459

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Overexpression of YWHAZ as an independent prognostic factor in adenocarcinoma of the esophago-gastric junction.2016

    • Author(s)
      Watanabe N, Komatsu S et al.
    • Journal Title

      Am J Cancer Res.

      Volume: 6 Pages: 2729-2736

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating miR-21 as an independent predictive biomarker for chemoresistance in esophageal squamous cell carcinoma2016

    • Author(s)
      Komatsu S et al.
    • Journal Title

      American Journal of Cancer Research

      Volume: 6

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas2016

    • Author(s)
      Ohtomo-Oda R, Komatsu S, Tsuda H et al.
    • Journal Title

      Hum Pathol

      Volume: 49 Pages: 145-155

    • DOI

      10.1016/j.humpath.2015.08.025

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer2015

    • Author(s)
      Miyamae M, Komatsu S et al.
    • Journal Title

      British Journal of Cancer

      Volume: 113 Issue: 10 Pages: 1467-1476

    • DOI

      10.1038/bjc.2015.366

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Malignant potential in pancreatic neoplasm; new insights provided by circulating miR-223 in plasma2015

    • Author(s)
      Komatsu S et al.
    • Journal Title

      Expert Opin Biol Ther.

      Volume: - Issue: 6 Pages: 1-13

    • DOI

      10.1517/14712598.2015.1029914

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma.2015

    • Author(s)
      Kobayashi H, Komatsu S etal.
    • Journal Title

      Oncotarget

      Volume: 6 Issue: 34 Pages: 36615-36624

    • DOI

      10.18632/oncotarget.5620

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] 食道扁平上皮癌患者血漿における癌抑制型miRNAの発現解析と抗がん核酸治療への応用2017

    • Author(s)
      木内 純、小松周平 他
    • Organizer
      第117回日本外科学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2017-04-27
    • Related Report
      2016 Research-status Report
  • [Presentation] Depleted tumor suppressive miR-148a in plasma as a treatment target in gastric cancer2017

    • Author(s)
      小松周平
    • Organizer
      第89回日本胃癌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Future perspective of liquid biopsy using microRNAs in blood of patients with hepatobiliary and pancreatic neoplasms2017

    • Author(s)
      小松周平
    • Organizer
      第76回日本癌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 胃癌患者血漿における癌抑制型miR-148aの発現解析と抗癌核酸治療への応用2017

    • Author(s)
      小松周平
    • Organizer
      第9回日本RNAi学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer2017

    • Author(s)
      今村泰輔 小松周平 他
    • Organizer
      米国外科学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Depleted tumor suppressor miR-655 in plasma contributes to poor outcomes and is a novel therapeutic target in ESCC2017

    • Author(s)
      木内 純 小松周平 他
    • Organizer
      米国外科学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 胃癌患者血漿における癌抑制型miR-148aの発現解析と抗がん核酸治療への応用2016

    • Author(s)
      小松周平 他
    • Organizer
      第75回癌学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 膵癌患者血漿における癌抑制型miRNAの発現解析と抗がん核酸治療への応用2016

    • Author(s)
      今村泰輔 小松周平 他
    • Organizer
      第116回 日本外科学会定期学術集会 大阪
    • Place of Presentation
      大阪国際会議場・リーガロイヤル大阪
    • Year and Date
      2016-04-14
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 血中遊離核酸を用いたLiquid Biopsyによる消化器がんの新たな外科診療の可能性2016

    • Author(s)
      小松周平 他
    • Organizer
      第116回 日本外科学会定期学術集会 大阪
    • Place of Presentation
      大阪国際会議場・リーガロイヤル大阪
    • Year and Date
      2016-04-14
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2019-03-29  

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