Project/Area Number |
15K10120
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Osaka Medical College |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
赤尾 幸博 岐阜大学, 大学院連合創薬医療情報研究科, 教授 (00222505)
|
Research Collaborator |
TANIGUCHI Kohei 大阪医科大学, 医学部, 助教 (70779686)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | microRNA / Warburg 効果 / PTBP1 / RNA helicase / MYC / Warburg効果 |
Outline of Final Research Achievements |
In this project, we found that cancer-specific energy metabolism (Warburg effect) is regulated by several organ-specific microRNAs (miRNAs). Especially, MIR122, 137 and 206 had organ specificity and regulated Warburg effect-associated genes, i.e., PKM or PTBP1. Also, we indicated that PTBP1 is novel oncogene in colorectal tumors and that up-regulation of PTBP1 was induced by dysregulation of the MIR1 and 133b. Moreover, we partially clarified the functions of the Warburg effect-associated genes in chemo-resistant cancer cells. Namely, PKM2 was dominant in cancer cells, but in chemo-resistant cancer cells, PKM1 was re-up-regulated through the reverse shift of PKM isoforms.
|