Clinical application to significance and growth control of the chromosome instability in carcinogenesis, the progress of gastrointestinal cancer
| Project/Area Number |
15K10127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University (2016-2017)
National Hospital Organization, Kyushu Cancer Center (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
江頭 明典 独立行政法人国立病院機構別府医療センター(臨床研究部), 臨床研究部, その他 (00419524)
藤 也寸志 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 院長 (20217459)
森田 勝 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他 (30294937)
沖 英次 九州大学, 大学病院, 助教 (70380392)
佐伯 浩司 九州大学, 大学病院, 助教 (80325448)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食道癌 / メチル化 / FANCJ / 染色体不安定性 / ファンコニ経路 / LINE-1メチル化 / LINE-1 / 喫煙 / 飲酒 |
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| Outline of Final Research Achievements |
In multiple esophageal cancer and multiple Lugol-voiding lesion of esophagus, the LINE-1 methylation in the esophageal nomal mucosa significantly decreased. We suggest that the genome-wide hypomethylation was wide participated in outbreak of many carcinogenesis. In addition, methylation abnormality of various chemokines and in cancer of the esophagus was associated with genome-wide hypomethylation.
An effect of the preoperation chemotherapy (5FU+CDDP) was high in esophageal cancer that had a low FANCJ expression, and the group that enforced 5FU+CDDP after surgery in a low FANCJ expression had a better prognosis than surgery alone group. Furthermore, in the patients of esophageal cancer that gave chemotherapy after surgery, the low FANCJ expression group significantly had a better prognosis than overexpression group. The expression of FANCJ can become a useful marker as effect measurement of the chemotherapy.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Clinicopathological characteristics of esophageal squamous cell carcinoma in patients younger than 50 years.2015
Author(s)
Kasagi Y, Morita M, Otsu H, Kawano H, Ando K, HiyoshiY, Ito S, Miyamoto Y, Saeki H, Oki E, Maehara Y
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Journal Title
Ann Surg Oncol
Volume: 22
Issue: 1
Pages: 311-315
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of surgical resection for the recurrence of esophageal cancer after radical esophagectomy.2015
Author(s)
Hiyoshi Y, Morita M, Kawano H, Otsu H, Ando K, Ito S, Miyamoto Y, Sakamoto Y, Saeki H, Oki E, Ikeda T, Baba H, Maehara Y
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Journal Title
Ann Surg Oncol
Volume: 22
Issue: 1
Pages: 206-240
DOI
Related Report
Peer Reviewed
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[Journal Article] Discrimination of p53 immunohistochemistry-positive tumors by its staining pattern in gastric cancer.2015
Author(s)
Ando K, Oki E, Saeki H, Yan Z, Tsuda Y, Hidaka G, Kasagi Y, Otsu H, Kawano H, Kitao H, Morita M, Maehara Y.
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Journal Title
Cancer Med.
Volume: 4
Issue: 1
Pages: 75-83
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Correlation of HER2 expression with clinicopathological characteristics and prognosis in resectable gastric cancer.2015
Author(s)
Otsu H, Oki E, Ikawa-Yoshida A, Kawano H, Ando K, Ida S, Kimura Y, Aishima S, Saeki H, Morita M, Kohnoe S, Oda Y, Maehara Y
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Journal Title
Anticancer Res
Volume: 35
Pages: 2441-6
Related Report
Peer Reviewed
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