| Project/Area Number |
15K10127
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyushu University (2016-2017)
National Hospital Organization, Kyushu Cancer Center (2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
江頭 明典 独立行政法人国立病院機構別府医療センター(臨床研究部), 臨床研究部, その他 (00419524)
藤 也寸志 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 院長 (20217459)
森田 勝 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, その他 (30294937)
沖 英次 九州大学, 大学病院, 助教 (70380392)
佐伯 浩司 九州大学, 大学病院, 助教 (80325448)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食道癌 / メチル化 / FANCJ / 染色体不安定性 / ファンコニ経路 / LINE-1メチル化 / LINE-1 / 喫煙 / 飲酒 |
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| Outline of Final Research Achievements |
In multiple esophageal cancer and multiple Lugol-voiding lesion of esophagus, the LINE-1 methylation in the esophageal nomal mucosa significantly decreased. We suggest that the genome-wide hypomethylation was wide participated in outbreak of many carcinogenesis. In addition, methylation abnormality of various chemokines and in cancer of the esophagus was associated with genome-wide hypomethylation.
An effect of the preoperation chemotherapy (5FU+CDDP) was high in esophageal cancer that had a low FANCJ expression, and the group that enforced 5FU+CDDP after surgery in a low FANCJ expression had a better prognosis than surgery alone group. Furthermore, in the patients of esophageal cancer that gave chemotherapy after surgery, the low FANCJ expression group significantly had a better prognosis than overexpression group. The expression of FANCJ can become a useful marker as effect measurement of the chemotherapy.
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