| Project/Area Number |
15K10136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
Kawamura Mikio 三重大学, 医学系研究科, リサーチアソシエイト (00722589)
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| Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学部附属病院, 講師 (00422824)
大北 喜基 三重大学, 医学部附属病院, 助教 (20378342)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
荒木 俊光 三重大学, 医学系研究科, 准教授 (70343217)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 回腸嚢炎 / 潰瘍性大腸炎 / DNA methylation / micro RNA / サイトカイン |
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| Outline of Final Research Achievements |
Comprehensive microRNA and mRNA expression patterns related to pouchitis were analyzed using ileal mucosa at the time of colectomy. Interferon gamma and FK506 binding protein mRNA levels in ileal mucosa could be predictive for the onset of pouchitis after surgery.
Using epigenomic analysis, we found specific micro RNAs to be methylated in rectal mucosal samples from patients with ulcerative colitis associated cancer, and could be used to identify patients with ulcerative colitis at high risk for developing neoplasia.
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