Comprehensive epigenome-transcriptome analysis of hepatocellular carcinoma after eradication of hepatitis C
Project/Area Number |
15K10168
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | National Hospital Organization, Kyushu Cancer Center (2017) Kyushu University (2015-2016) |
Principal Investigator |
SUGIMACHI KEISHI 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 肝胆膵外科医長 (90452763)
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Co-Investigator(Kenkyū-buntansha) |
鈴木 穣 東京大学, 大学院新領域創成科学研究科, 教授 (40323646)
宮野 悟 東京大学, 医科学研究所, 教授 (50128104)
三森 功士 九州大学, 大学病院, 教授 (50322748)
調 憲 群馬大学, 大学院医学系研究科, 教授 (70264025)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 肝細胞癌 / ウイルス学的著効 / エピゲノム / メチル化 / ゲノム・エピゲノムの統合解析 |
Outline of Final Research Achievements |
We aimed to identify epigenomic alteration for carcinogenesis and recurrence of hepatocellular carcinoma (HCC). We employed microarray-based profiling of micro RNA (miR) expression from exosome in plasma of HCC patients. We found miRs which were associated with HCC recurrence. Decreased expression of miR-718 was associated with proliferation and recurrence of HCC by targeting HOXB8. Then, miR expression analysis of bone marrow cells in HCC patients was employed. We identified altered miR expression in macrophage and lymphocyte fractions involved in recurrence. The comprehensive methylation analysis of whole genome was done in HCC patients with or without hepatitis C. The analysis revealed that differentially methylated regions of noncancerous liver tissue was maintained even after eradication of virus. These findings indicated that epigenomic alteration of host cells are involved in recurrence of HCC.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Altered expression of Hippo signaling pathway molecules in intrahepatic cholangiocarcinoma.2017
Author(s)
Sugimachi K, Nishio M, Aishima S, Kuroda Y, Iguchi T, Komatsu H, Hirata H, Sakimura S, Eguchi H, Bekki Y, Takenaka K, Maehara Y, Suzuki A, Mimori K.
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Journal Title
ONCOLOGY
Volume: -
Issue: 1
Pages: 67-74
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Japanese genome-wide association study identifies a significant colorectal cancer susceptibility locus at chromosome 10p14.2017
Author(s)
Takahashi Y, Sugimachi K, Yamamoto K, Niida A, Shimamura T, Sato T, Watanabe M, Tanaka J, Kudo S, Sugihara K, Hase K, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Suzuki Y, Miyano S, Mori M, Mimori K
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Journal Title
Cancer Sci.
Volume: 108(11)
Issue: 11
Pages: 2239-2247
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma.2017
Author(s)
Komatsu H, Masuda T, Iguchi T, Nambara S, Sato K, Hu Q, Hirata H, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
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Journal Title
Anticancer Res.
Volume: 37(3)
Pages: 1083-1090
Related Report
Peer Reviewed / Open Access
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[Journal Article] miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.2016
Author(s)
Iguchi T, Nambara S, Masuda T, Komatsu H, Ueda M, Kidogami S, Ogawa Y, Hu Q, Sato K, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
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Journal Title
PLoS One.
Volume: 11(11)
Issue: 11
Pages: e0165912-e0165912
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma2016
Author(s)
Komatsu H, Iguchi T, Masuda T, Hirata H, Ueda M, Kidogami S, Ogawa Y, Sato K, Hu Q, Nambara S, Saito T, Sakimura S, Uchi R, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
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Journal Title
Ann Surg Oncol.
Volume: 24(3)
Issue: 3
Pages: 850-859
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Somatic mutations in plasma cell-free DNA are diagnostic markers for esophageal squamous cell carcinoma recurrence2016
Author(s)
Ueda M, Iguchi T, Masuda T, Nakahara Y, Hirata H, Uchi R, Niida A, Momose K, Sakimura S, Chiba K, Eguchi H, Ito S, Sugimachi K, Yamasaki M, Suzuki Y, Miyano S, Doki Y, Mori M, Mimori K
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Journal Title
Oncotarget
Volume: 7(38)
Issue: 38
Pages: 62280-62291
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis2016
Author(s)
Sugimachi K, Yamaguchi R, Eguchi H, Ueda M, Niida A, Sakimura S, Hirata H, Uchi R, Shinden Y, Iguchi T, Morita K, Yamamoto K, Miyano S, Mori M, Maehara Y, Mimori K
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Journal Title
Ann Surg Oncol
Volume: 23(Suppl 4)
Issue: S4
Pages: 546-551
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] HOXB7 Expression is a Novel Biomarker for Long-term Prognosis After Resection of Hepatocellular Carcinoma.2016
Author(s)
Komatsu H, Iguchi T, Masuda T, Ueda M, Kidogami S, Ogawa Y, Nambara S, Sato K, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
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Journal Title
Anticancer Res.
Volume: 36(6)
Pages: 2767-73
Related Report
Peer Reviewed / Open Access
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[Journal Article] Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal Cancer.2016
Author(s)
Sugimachi K, Matsumura T, Shimamura T, Hirata H, Uchi R, Ueda M, Sakimura S, Iguchi T, Eguchi H, Masuda T, Morita K, Takenaka K, Maehara Y, Mori M, Mimori K.
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Journal Title
Ann Surg Oncol.
Volume: 23(12)
Issue: 12
Pages: 3948-3955
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma.2016
Author(s)
Hirata H, Sugimachi K, Komatsu H, Ueda M, Masuda T, Uchi R, Sakimura S, Nambara S, Saito T, Shinden Y, Iguchi T, Eguchi H, Ito S, Terashima K, Sakamoto K, Hirakawa M, Honda H, Mimori K.
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Journal Title
Cancer Res.
Volume: 76(11)
Issue: 11
Pages: 3265-76
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased Copy Number of the Gene Encoding SF3B4 Indicates Poor Prognosis in Hepatocellular Carcinoma.2016
Author(s)
Iguchi T, Komatsu H, Masuda T, Nambara S, Kidogami S, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
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Journal Title
Anticancer Res.
Volume: 36(5)
Pages: 2139-44
Related Report
Peer Reviewed / Open Access
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[Journal Article] Integrated Molecular Profiling of Human Gastric Cancer Identifies DDR2 as a Potential Regulator of Peritoneal Dissemination.2016
Author(s)
Kurashige J, Hasegawa T, Niida A, Sugimachi K, Deng N, Mima K, Uchi R, Sawada G, Takahashi Y, Eguchi H, Inomata M, Kitano S, Fukagawa T, Sasako M, Sasaki H, Sasaki S, Mori M, Yanagihara K, Baba H, Miyano S, Tan P, Mimori K.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 22371-22371
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma.2016
Author(s)
Komatsu H, Iguchi T, Ueda M, Nambara S, Saito T, Hirata H, Sakimura S1, Takano Y1, Uchi R1, Shinden Y, Eguchi H, Masuda T, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
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Journal Title
Oncol Rep
Volume: 35
Issue: 4
Pages: 2073-80
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] HOXB7 Expression is a Novel Biomarker for Long-term Prognosis after Resection of Hepatocellular Carcinoma2016
Author(s)
Komatsu H, Iguchi T, Masuda T, Ueda M, Kidogami S, Ogawa Y, Nambara S, Sato K, Hu Q, Saito T, Hitarta H, Sakimura S, Uchi R, Hayashi N, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K
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Journal Title
Anticancer Res
Volume: accept
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Favorable Prognosis in Patients with Sustained Virological Response to Antiviral Therapy, Including Interferon, for Chronic Hepatitis C Before Hepatic Resection for Hepatocellular Carcinoma.2015
Author(s)
Shirabe K, Sugimachi K, Harada N, Kayashima H, Maeda T, Tsujita E, Minagawa R, Kajiyama K, Yoshiya S, Maehara Y.
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Journal Title
Anticancer Res.
Volume: 35
Pages: 6963-9
Related Report
Peer Reviewed
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[Journal Article] Identification of Recurrence-Related microRNAs from Bone Marrow in Hepatocellular Carcinoma Patients.2015
Author(s)
Sugimachi K, Sakimura S, Tomokuni A, Uchi R, Hirata H, Komatsu H, Shinden Y, Iguchi T, Eguchi H, Masuda T, Morita K, Shirabe K, Eguchi H, Maehara Y, Mori M, Mimori K
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Journal Title
J Clin Med.
Volume: 4
Issue: 8
Pages: 1600-11
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Downregulation of PRRX1 Confers Cancer Stem Cell-Like Properties and Predicts Poor Prognosis in Hepatocellular Carcinoma.2014
Author(s)
Hirata H, Sugimachi K, Takahashi Y, Ueda M, Sakimura S, Uchi R, Kurashige J, Takano Y, Nanbara S, Komatsu H, Saito T, Shinden Y, Iguchi T, Eguchi H, Atsumi K, Sakamoto K, Doi T, Hirakawa M, Honda H, Mimori K.
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Journal Title
Ann Surg Oncol.
Volume: epub
Issue: S3
Pages: 1402-9
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 肝内胆管癌の新たな悪性度規定因子としてのHippo 経路コンポーネントの発現異常の意義2017
Author(s)
杉町 圭史, 西尾 美希, 別城 悠樹, 相島 慎一, 小松 久晃:4, 西田 康二郎, 遠藤 和也, 東 秀史, 竹中 賢治, 鈴木 聡, 三森 功士
Organizer
第117回日本外科学会定期学術集会
Related Report
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