| Project/Area Number |
15K10180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
古川 勝規 千葉大学, 大学院医学研究院, 講師 (00400987)
高野 重紹 千葉大学, 大学院医学研究院, 助教 (20436380)
宮崎 勝 国際医療福祉大学, 大学病院, 教授 (70166156)
加藤 厚 国際医療福祉大学, 医学部, 教授 (70344984)
大塚 将之 千葉大学, 大学院医学研究院, 教授 (90334185)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経内分泌腫瘍 / 神経内分泌癌 / Sox2 / Pdx1 / hASH1 / NeuroD / 膵神経内分泌腫瘍 / mASH1 / 膵臓発生 / Pdx-1 |
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| Outline of Final Research Achievements |
The aim of this study is elucidate the pathophysiology and tumor biology of pancreatic neuroendocrine tumors (p-NETs). We assessed the expression of transcription factors SOX2 and Pdx1 essential for the normal fetal development of pancreatic neuroendocrine cells in 46 surgically resected p-NETs. SOX2 was positive in 6 of 46 p-NETs. 71% of NEC patients (5 of 7) showed positive for SOX2. SOX2 was specifically expressed in NEC. Patients with SOX2 positive p-NET showed the significantly shorter survival than patients with SOX2 negative p-NET. By experiments using cell line, Sox2 expression has a role to maintain stem cell related factor, c-myc and Oct4. High Pdx1 expression was seen in 25 of 46 p-NET patients. None of the NEC patients showed high Pdx1 expression. The expression patterns of SOX2 and Pdx1 highly correlated with prognosis of p-NETs. These expression patterns may represent the biological and pathophysiological difference of p-NETs and indicate the origin of tumor.
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