New criteria of pancreatic neuroendocrine tumors depending on expression levels of transcription factors related to neural and endocrine cell development
| Project/Area Number |
15K10180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
古川 勝規 千葉大学, 大学院医学研究院, 講師 (00400987)
高野 重紹 千葉大学, 大学院医学研究院, 助教 (20436380)
宮崎 勝 国際医療福祉大学, 大学病院, 教授 (70166156)
加藤 厚 国際医療福祉大学, 医学部, 教授 (70344984)
大塚 将之 千葉大学, 大学院医学研究院, 教授 (90334185)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経内分泌腫瘍 / 神経内分泌癌 / Sox2 / Pdx1 / hASH1 / NeuroD / 膵神経内分泌腫瘍 / mASH1 / 膵臓発生 / Pdx-1 |
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| Outline of Final Research Achievements |
The aim of this study is elucidate the pathophysiology and tumor biology of pancreatic neuroendocrine tumors (p-NETs). We assessed the expression of transcription factors SOX2 and Pdx1 essential for the normal fetal development of pancreatic neuroendocrine cells in 46 surgically resected p-NETs. SOX2 was positive in 6 of 46 p-NETs. 71% of NEC patients (5 of 7) showed positive for SOX2. SOX2 was specifically expressed in NEC. Patients with SOX2 positive p-NET showed the significantly shorter survival than patients with SOX2 negative p-NET. By experiments using cell line, Sox2 expression has a role to maintain stem cell related factor, c-myc and Oct4. High Pdx1 expression was seen in 25 of 46 p-NET patients. None of the NEC patients showed high Pdx1 expression. The expression patterns of SOX2 and Pdx1 highly correlated with prognosis of p-NETs. These expression patterns may represent the biological and pathophysiological difference of p-NETs and indicate the origin of tumor.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Identification of a novel serum biomarker for pancreatic cancer, C4b-binding protein α-chain (C4BPA) by quantitative proteomic analysis using tandem mass tags.2016
Author(s)
Sogawa K, Takano S, Iida F, Satoh M, Tsuchida S, Kawashima Y, Yoshitomi H, Sanda A, Kodera Y, Takizawa H, Mikata R, Ohtsuka M, Shimizu H, Miyazaki M, Yokosuka O, Nomura F.
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Journal Title
Br J Cancer.
Volume: 115
Issue: 8
Pages: 949-956
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 膵・神経分化マーカーを用いた転移性pNETの治療戦略2017
Author(s)
賀川真吾, 吉富秀幸, 清水宏明, 古川勝規, 高屋敷 吏, 高野重紹, 久保木 知, 鈴木大亮, 酒井 望, 野島広之 , 細川 勇, 大塚将之
Organizer
第48回 日本膵臓学会大会
Related Report
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