| Project/Area Number |
15K10241
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SAKATA RYUZO 京都大学, 医学研究科, 名誉教授 (20325781)
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| Co-Investigator(Kenkyū-buntansha) |
池田 義 京都大学, 医学研究科, 准教授 (40281092)
山崎 和裕 京都大学, 医学研究科, 講師 (50464227)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA JUN 京都大学, その他部局等, 教授 (50335288)
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| Research Collaborator |
MASUMOTO HIDETOSHI 京都大学, 大学院医学研究科, 特定助教 (70645754)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 末梢動脈外科学 / iPS細胞 / 血管新生 / 血管内皮細胞 / 抹消動脈外科学 |
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| Outline of Final Research Achievements |
The transplantation of human iPS cell-derived endothelial cells and vascular mural cells with gelatin sponges revealed a significant improvement of blood flow and a higher vascular density in the ischemic lindlimb. Ku-80 positive human cells are observed in the newly-formed vasculature indicating the contribution of transplanted human cells toward the vascular regeneration of the host. Furthermore, the transplantation induced the angiogenesis mediated by the up-regulation of paracrine factors. There results would serve as a basis toward the development of a new vascular regenerative therapy for a severe limb ischemia in the future.
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