Development of the therapy fot AAA induced by mechanichal stress

Research Project

Project/Area Number	15K10242
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cardiovascular surgery
Research Institution	Osaka University
Principal Investigator	TANIYAMA YOSHIAKI 大阪大学, 医学系研究科, 招へい教授 (60372611)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	大動脈瘤 / ペリオスチン / メカニカルストレス / 喫煙 / 大血管 / 腹部大動脈瘤
Outline of Final Research Achievements	The development of the medical therapy to restrain pathologic progress in the state that the aortic aneurysm has only the surgical treatment. We analyze a mouse aortic aneurysm model cyclopedically; and periostin gene (confirmed that PN) increased in response to mechanical stress.) Therefore I confirmed that PN restraint led to improvement of the AAA using two kinds of AAA models and PNKO mice. In addition, I confirmed that blood PN rose by smoking by the analysis of the blood sample before and after the clinical smoking cessation. Possibility of the PN restraint was suggested as a new target of the AAA.

Report

(4 results)