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Development of the therapy fot AAA induced by mechanichal stress

Research Project

Project/Area Number 15K10242
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionOsaka University

Principal Investigator

TANIYAMA YOSHIAKI  大阪大学, 医学系研究科, 招へい教授 (60372611)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords大動脈瘤 / ペリオスチン / メカニカルストレス / 喫煙 / 大血管 / 腹部大動脈瘤
Outline of Final Research Achievements

The development of the medical therapy to restrain pathologic progress in the state that the aortic aneurysm has only the surgical treatment. We analyze a mouse aortic aneurysm model cyclopedically; and periostin gene (confirmed that PN) increased in response to mechanical stress.) Therefore I confirmed that PN restraint led to improvement of the AAA using two kinds of AAA models and PNKO mice. In addition, I confirmed that blood PN rose by smoking by the analysis of the blood sample before and after the clinical smoking cessation. Possibility of the PN restraint was suggested as a new target of the AAA.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Presentation] Selective blockade of periostin exon17 preservre cardiac performance in acute myocardial infarction.2016

    • Author(s)
      谷山義明
    • Organizer
      The 4th Inflammation and Regeneration Meeting
    • Place of Presentation
      東京
    • Year and Date
      2016-01-09
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 炎症性疾患におけるペリオスチンバリアントの役割2015

    • Author(s)
      眞田文博
    • Organizer
      脳心血管抗加齢研究会2015
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2015-11-29
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Selective Blockade of Periostin Exon-17 Ameriorates Cardiac Performance in Acute Myocardial Infarction2015

    • Author(s)
      Fumihiro Sanada
    • Organizer
      The 21st Annual Meeting of Japan Socity of Gene Therapy, The 1st International Symposium of the Asia-Pasific Gene Therapy Consortium
    • Place of Presentation
      Osaka
    • Year and Date
      2015-07-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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