Development of the therapy fot AAA induced by mechanichal stress
| Project/Area Number |
15K10242
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 大動脈瘤 / ペリオスチン / メカニカルストレス / 喫煙 / 大血管 / 腹部大動脈瘤 |
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| Outline of Final Research Achievements |
The development of the medical therapy to restrain pathologic progress in the state that the aortic aneurysm has only the surgical treatment. We analyze a mouse aortic aneurysm model cyclopedically; and periostin gene (confirmed that PN) increased in response to mechanical stress.) Therefore I confirmed that PN restraint led to improvement of the AAA using two kinds of AAA models and PNKO mice. In addition, I confirmed that blood PN rose by smoking by the analysis of the blood sample before and after the clinical smoking cessation. Possibility of the PN restraint was suggested as a new target of the AAA.
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Report
(4 results)
Research Products
(3 results)
