Development of a protection method to prevent spinal cord ischemia by promoting spinal collateral circulation with proangiogenic cytokine-inducer.

Research Project

Project/Area Number	15K10243
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cardiovascular surgery
Research Institution	Osaka University
Principal Investigator	Shimamura Kazuo 大阪大学, 医学系研究科, 助教 (10507205)
Co-Investigator(Kenkyū-buntansha)	倉谷徹大阪大学, 医学系研究科, 寄附講座教授 (90448035) 鳥飼慶大阪大学, 医学系研究科, 講師 (70364792)
Research Collaborator	MIYAGAWA Shigeru
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	大動脈瘤 / 脊髄虚血 / 再灌流障害 / 胸腹部大動脈瘤 / 血管新生
Outline of Final Research Achievements	The objective of this study is to develop a protection method to prevent spinal cord ischemia by promoting spinal collateral circulation with proangiogenic cytokine-inducer (ONO-1301). We found that intravenously injected ONO-1301 incorporated liposome-based nanoparticle was selectively accumulated in ischemic area. Histologically, gene expression of proangiogenic cytokines of hepatocyte growth factor or angiopoietin-1 in the ischemic area were significantly higher and CD31-positive capillaries in the ischemic area were significantly greater in the ONO-1301 group.