| Project/Area Number |
15K10245
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
元松 祐馬 九州大学, 医学研究院, 共同研究員 (20746870)
田ノ上 禎久 九州大学, 医学研究院, 准教授 (40372742)
藤本 智子 九州大学, 大学病院, その他(移行) (40567377)
園田 拓道 九州大学, 医学研究院, 助教 (50596830)
牛島 智基 九州大学, 大学病院, 助教 (70529875)
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| Project Period (FY) |
2015-10-21 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心臓エナジェティクス / 動脈インピーダンス / 後負荷 / ステントグラフト / 左室肥大 |
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| Outline of Final Research Achievements |
We aimed to elucidate the impact of stent-grafting on cardiac afterload, function and remodeling. In anesthetized dogs, a stent-graft was deployed into the descending aorta. The pressures and volumes of the left ventricle and the pressures and flows of the ascending aorta were measured before, after and 90-day after stent-grafting to obtain the left ventricular pressure-volume relations and aortic input impedance, respectively. After sacrifice, the left ventricle was weighed. The arterial compliance decreased and characteristic impedance increased significantly after stent-grafting, while the total vascular resistance remained unaltered. The arterial elastance significantly increased after stent-grafting, however the ventriculoarterial coupling (LV efficiency) remained unaltered. The indexed LV mass of the stent-graft group was significantly higher compared with the control group. Stent-grafting increased cardiac afterload and caused LV hypertrophy.
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