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Intraoperative collection of autologous platelet-rich plasma from the cardiopulmonary bypass circuit upon initiation of extracorporeal circulation

Research Project

Project/Area Number 15K10247
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionKawasaki Medical School

Principal Investigator

Tanemoto Kazuo  川崎医科大学, 医学部, 教授 (90330547)

Research Collaborator Honda Takeshi  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords血小板 / 自己血 / ヘパリン / 血小板機能 / 血小板凝集能 / 心臓手術 / 止血 / 成分採血
Outline of Final Research Achievements

Under cardiac surgery with cardiopulmonary bypass, an autologous platelet product was prepared using the Haemonetics Component Collection System(R) by drawing blood from the cardiopulmonary circuit immediately after cardiopulmonary bypass was initiated. The blood sample ware taken at three points for examination, A: beginning of surgery, B: immediately after heparin reversal with protamine following discontinuation of cardiopulmonary bypass, C: after the collected autologous platelet product was returned to the patient. Platelet count and platelet aggregation ability were compared.
Autologous platelets can be collected by drawing blood from the cardiopulmonary bypass circuit, and this method maintains effective aggregation ability upon returning the platelets to the patient.

Academic Significance and Societal Importance of the Research Achievements

少子高齢化に伴い、近い将来に直面するであろう血液製剤不足に対し、有効な打開策として自己血小板を採取する方法を確立した。心臓大血管手術中に人工心肺回路から有効な血小板凝集能を持った自己血小板を採取することができ、それを返血することによって血小板数および血小板凝集能の改善が得られることが確認された。また、人工心肺回路からの自己血小板採取は、これらの手術での出血量減少および血液製剤使用量の削減についての効果も期待できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2017 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Intraoperative collection of autologous platelet-rich plasma from the cardiopulmonary bypass circuit upon initiation of extracorporeal circulation.2019

    • Author(s)
      Takeshi Honda, Taishi Tamura, Noriaki Kuwada, Takahiko Yamasawa, Yoshiko Watanabe, Hiroshi Furukawa, Yasuhiro Yunoki, Atushi Tabuchi, Yuji Kanaoka, Kazuo Tanemoto
    • Journal Title

      General Thoracic and Cardiovascular Surgery

      Volume: 投稿中

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 自己血小板貯血における採血前ヘパリン投与が採取血小板の凝集能に及ぼす影響に関する検討2015

    • Author(s)
      滝内宏樹,種本和雄
    • Journal Title

      川崎医学会誌

      Volume: 41 Pages: 143-151

    • NAID

      110009986976

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 心臓大血管手術中人工心肺回路からの自己濃厚血小板採取方法確立に関する研究2018

    • Author(s)
      本田 威、田村 太志、桑田 憲明、山澤 隆彦、渡部 芳子、古川 博史、柚木 靖弘、田淵 篤、種本 和雄
    • Organizer
      第48回日本心臓血管外科学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Intraoperative Autologous Platelet-Rich Plasma Collection from the Cardiopulmonary Bypass Circuit.2018

    • Author(s)
      Takeshi Honda, Kazuo Tanemoto, Takahiko Yamasawa, Hiroshi Furukawa
    • Organizer
      The 26th Annual Meeting of the Asian Society for Cardiovascular and Thoracic Surgery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 心臓大血管手術中人工心肺回路からの自己濃厚血小板採取方法確立に関する研究2017

    • Author(s)
      本田 威、田村 太志、桒田 憲明、山澤 隆彦、渡部 芳子、古川 博史、柚木 靖弘、田淵 篤、種本 和雄
    • Organizer
      第70回日本胸部外科学会定期学術集会
    • Related Report
      2017 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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