Development of the new therapy for the arteriosclerosis obliterans applying cellular senescence suppressive effect of 5-ALA
| Project/Area Number |
15K10248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular surgery
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
森田 一郎 川崎医科大学, 医学部, 准教授 (30200413)
山辻 知樹 川崎医科大学, 医学部, 准教授 (40379730)
高岡 宗徳 川崎医科大学, 医学部, 講師 (50548568)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | 5-ALA / 5-アミノレブリン酸（ALA） |
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| Outline of Final Research Achievements |
There is not the effective therapeutic drug suppressing the vascular endothelial cells injury which are a cause of the arteriosclerosis obliterans (ASO). 5-aminolevulinic acid (ALA) is indispensable to an energy production in the mitochondria and is concerned with cellular aging. It was shown that ALA held oxidative stress and the development of organ damage in check recently. This study aimed at showing that ALA suppress vascular endothelial injury and arteriosclerosis. We gave ALA to arteriosclerosis model mouse, and we tested it, but there was no arteriosclerosis suppression effect, blood cholesterol level, arteriosclerosis, vascular endothelial cells injury. We introduced the high sensitive ELISA system using the antibody for oxidation phosphatidylcholine to measure an oxidation LDL level.
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Report
(4 results)
Research Products
(6 results)
