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Development of the new therapy for the arteriosclerosis obliterans applying cellular senescence suppressive effect of 5-ALA

Research Project

Project/Area Number 15K10248
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionKawasaki Medical School

Principal Investigator

Hirabayashi Yoko  川崎医科大学, 医学部, 講師 (90341106)

Co-Investigator(Kenkyū-buntansha) 森田 一郎  川崎医科大学, 医学部, 准教授 (30200413)
山辻 知樹  川崎医科大学, 医学部, 准教授 (40379730)
高岡 宗徳  川崎医科大学, 医学部, 講師 (50548568)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywords5-ALA / 5-アミノレブリン酸(ALA)
Outline of Final Research Achievements

There is not the effective therapeutic drug suppressing the vascular endothelial cells injury which are a cause of the arteriosclerosis obliterans (ASO). 5-aminolevulinic acid (ALA) is indispensable to an energy production in the mitochondria and is concerned with cellular aging. It was shown that ALA held oxidative stress and the development of organ damage in check recently. This study aimed at showing that ALA suppress vascular endothelial injury and arteriosclerosis. We gave ALA to arteriosclerosis model mouse, and we tested it, but there was no arteriosclerosis suppression effect, blood cholesterol level, arteriosclerosis, vascular endothelial cells injury. We introduced the high sensitive ELISA system using the antibody for oxidation phosphatidylcholine to measure an oxidation LDL level.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2017 2016 2015

All Presentation (6 results)

  • [Presentation] 両下肢深部静脈血栓症、下大静脈血栓、肺塞栓症を認めた症例に対し下大静脈フィルターを留置と抗凝固療法で加療した1例2017

    • Author(s)
      平林 葉子, 森田 一郎, 吉田 将和, 湯川 拓郎, 深澤 拓也, 杭ノ瀬 昌彦, 猶本 良夫
    • Organizer
      第37回日本静脈学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生命予後からみた下腿血行再建指南2017

    • Author(s)
      森田一郎,平林葉子,磯田竜太郎,渡邊達也,平林葉子,杭ノ瀬昌彦,猶本良夫
    • Organizer
      第58回日本脈管学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 当院における深部静脈血栓症に対する血栓除去術施行 症例の検討2016

    • Author(s)
      平林葉子, 森田一郎, 磯田竜太郎, 湯川拓郎, 猶本良夫
    • Organizer
      第44 回日本血管外科学会学術総会
    • Place of Presentation
      ホテル グランパシフィック LE DAIBA,東京都港区
    • Related Report
      2016 Research-status Report
  • [Presentation] 一次性下肢静脈瘤血管内レーザー治療の合併症と対策2016

    • Author(s)
      平林葉子, 森田一郎, 磯田竜太郎, 吉田将和, 深澤拓也, 猶本良夫
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場,大阪市
    • Related Report
      2016 Research-status Report
  • [Presentation] 下肢静脈瘤血管内レーザー焼灼術後の再疎通症例の検討2015

    • Author(s)
      平林葉子、森田一郎、磯田竜太郎、猶本良夫
    • Organizer
      第43回日本血管外科学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-06-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 一次性下肢静脈瘤における小伏在静脈レーザー焼灼術の治療成績2015

    • Author(s)
      平林葉子、森田一郎、磯田竜太郎、深澤拓也、猶本良夫
    • Organizer
      第115回日本外科学会定期学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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