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Identification of a new driver oncogene mutation based on comparison of the smoking amount in lung squamous cell carcinoma

Research Project

Project/Area Number 15K10263
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionOita University (2017)
Kyushu University (2015-2016)

Principal Investigator

Okamoto Tatsuro  大分大学, 医学部, 准教授 (80568626)

Co-Investigator(Kenkyū-buntansha) 諸富 洋介  九州大学, 医学研究院, 助教 (60645365)
田川 哲三  九州大学, 大学病院, その他 (90419557)
杉尾 賢二  大分大学, 医学部, 教授 (70235927)
小副川 敦  大分大学, 医学部, 助教 (90432939)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords肺扁平上皮癌 / 次世代シーケンス / 喫煙量 / 遺伝子変異 / 非小細胞肺癌 / 扁平上皮癌
Outline of Final Research Achievements

Recent studies suggest that cancers occurring in never/light smokers and cancers occurring in heavy smokers have different characteristics and genetic alterations in non-small-cell lung cancer. In this study, we investigated comprehensive gene expression by next generation RNA sequence in lung squamous cell carcinoma of never/light smokers and of heavy smokers in detail, and searched for candidate oncogene related to patients prognosis. (2) Clinical significance of mutation burden in lung squamous cell carcinoma was examined by next generation exosome sequence using cancer-related gene panel.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (4 results)

  • [Journal Article] Clinical and Genetic Implications of Mutation Burden in Squamous Cell Carcinoma of the Lung2018

    • Author(s)
      Okamoto Tatsuro、Takada Kazuki、Sato Seijiro、Toyokawa Gouji、Tagawa Tetsuzo、Shoji Fumihiro、Nakanishi Ryota、Oki Eiji、Koike Terumoto、Nagahashi Masayuki、Ichikawa Hiroshi、Shimada Yoshifumi、Watanabe Satoshi、Kikuchi Toshiaki、Akazawa Kouhei、Lyle Stephen、Takabe Kazuaki、Okuda Shujiro、Sugio Kenji
    • Journal Title

      Annals of Surgical Oncology

      Volume: 25 Issue: 6 Pages: 1564-1571

    • DOI

      10.1245/s10434-018-6401-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical Impact and Risk Factors for Skeletal Muscle Loss After Complete Resection of Early Non-small Cell Lung Cancer2018

    • Author(s)
      Takamori Shinkichi、Toyokawa Gouji、Okamoto Tatsuro、Shimokawa Mototsugu、Kinoshita Fumihiko、Kozuma Yuka、Matsubara Taichi、Haratake Naoki、Akamine Takaki、Takada Kazuki、Katsura Masakazu、Hirai Fumihiko、Shoji Fumihiro、Tagawa Tetsuzo、Oda Yoshinao、Honda Hiroshi、Maehara Yoshihiko
    • Journal Title

      Ann Surg Oncol

      Volume: 25 Issue: 5 Pages: 1229-1236

    • DOI

      10.1245/s10434-017-6328-y

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Programmed Death-Ligand 1 Expression and EGFR Mutations in Multifocal Lung Cancer2018

    • Author(s)
      Haratake Naoki、Toyokawa Gouji、Takada Kazuki、Kozuma Yuka、Matsubara Taichi、Takamori Shinkichi、Akamine Takaki、Katsura Masakazu、Shoji Fumihiro、Okamoto Tatsuro、Oda Yoshinao、Maehara Yoshihiko
    • Journal Title

      Ann Thorac Surg

      Volume: 105 Issue: 2 Pages: 448-454

    • DOI

      10.1016/j.athoracsur.2017.09.025

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 喫煙量が肺扁平上皮癌の腫瘍生物学に及ぼす影響2017

    • Author(s)
      岡本 龍郎、高田 和樹、佐藤 征二郎、松原 太一、上妻 由佳、原武 直紀、高森 信吉、赤嶺 貴紀、桂 正和、豊川 剛二、庄司 文裕、土田 正則、前原 喜彦
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺扁平上皮癌に認められる遺伝子異常と遺伝子変異量の臨床的特徴2017

    • Author(s)
      岡本 龍郎、高田 和樹、庄司 文裕、豊川 剛二、沖 英次、永橋 昌幸、杉尾 賢二、若井 俊文、前原 喜彦
    • Organizer
      第76回日本癌学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 非小細胞肺癌N1症例における腫瘍発生部位の重要性2016

    • Author(s)
      岡本龍郎、庄司文裕、豊川剛二、上妻由佳、松原太一、原武直紀、赤嶺貴紀、高森信吉、高田和樹、桂 正和、前原喜彦
    • Organizer
      第69回日本胸部外科学会総会
    • Place of Presentation
      岡山
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 肺癌進展におけるリンパ節転移の腫瘍生物学的役割とリンパ節郭清の意義2016

    • Author(s)
      岡本龍郎,、島松晋一郎、高田和樹、桂正和、原武直紀、赤嶺貴紀、高森信吉、鈴木雄三、 藤下卓才、豊川剛二、庄司文裕、前原喜彦
    • Organizer
      第33回日本呼吸器外科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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