| Project/Area Number |
15K10265
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮脇 美千代 大分大学, 医学部, 講師 (30404388)
杉尾 賢二 大分大学, 医学部, 教授 (70235927)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 粘液産生性細気管支肺胞上皮癌 / targeted resequencing / primary culture / cell cycle / energy metabolism / 浸潤性粘液産生性腺癌 |
|---|
| Outline of Final Research Achievements |
Genomic DNA was extracted for 13 cases of mucin-producing bronchioloalveolar epithelial cancer (invasive mucinous adenocarcinoma, IMA in the new WHO classification) in which paraffin-embedded sections are available, and targeted resequencing by Ion AmpliSeq Cancer Hotspot Panel v 2 I made Thing. Among 13 cases, 10 cases were analyzable. As gene mutation, 4 cases of K-ras mutation, 3 cases of TP53 mutation, others, LKB1 mutation, PIK3CA mutation, EGFR mutation, ATM mutation were confirmed in each case.
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