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Comprehensive analysis of lung adenocarcinoma focus on the recurrence and response to chemotherapy

Research Project

Project/Area Number 15K10275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionFukushima Medical University (2016-2017)
National Cancer Center Japan (2015)

Principal Investigator

Saito Motonobu  福島県立医科大学, 医学部, 講師 (90611749)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肺腺癌 / ドライバー遺伝子 / 遺伝子融合 / 遺伝子変異 / 肺腺がん
Outline of Final Research Achievements

We performed a comprehensive genetic analysis for lung adenocarcinomas (LADC) and found that the driver fusion cases showed a distinct profile with smaller numbers of nonsynonymous mutations in cancer-related genes or truncating mutations in SWI/SNF chromatin remodeling. On the other hand, pan-negative LADCs appear to develop from a large number of gene mutations, including mutations in TP53 and other cancer-related genes. Next, we have compared the frequency of each driver genes between Japan and US cohort. EGFR mutations are more prevalent in Japanese patients, whereas KRAS and BRAF mutations are more prevalent in the US. To date, the molecularly targeted drugs for KRAS mutations have not developed yet, targeted therapy have not adapted the patients with LADC in the US. In conclusion, the information of driver genes will aid in the selection of appropriate targeted therapy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (25 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (3 results) Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 10 results,  Open Access: 10 results,  Acknowledgement Compliant: 4 results) Presentation (7 results) (of which Int'l Joint Research: 6 results) Book (4 results) Remarks (1 results)

  • [Int'l Joint Research] NIH(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] National Institutes of Health(米国)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research] IMPPC(Spain)

    • Related Report
      2015 Research-status Report
  • [Journal Article] Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy.2018

    • Author(s)
      Saito M, Suzuki H, Kono K, Takenoshita S, Kohno T.
    • Journal Title

      Surg Today

      Volume: 48 Issue: 1 Pages: 1-8

    • DOI

      10.1007/s00595-017-1497-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer.2018

    • Author(s)
      Saito M, Saito K, Shiraishi K, Maeda D, Suzuki H, Minamiya Y, Kono K, Kohno T, Goto A.
    • Journal Title

      Mol Clin Oncol.

      Volume: 8 Pages: 310-314

    • DOI

      10.3892/mco.2017.1536

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases.2017

    • Author(s)
      Goto A, Tanaka M, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Kuriyama S, Konno H, Imai K, Saito H, Minamiya Y, Maeda D.
    • Journal Title

      PLoS One.

      Volume: 12 Issue: 7 Pages: 1-6

    • DOI

      10.1371/journal.pone.0181270

    • NAID

      120007089063

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer.2017

    • Author(s)
      George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel AH, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Jang SJ, Petersen I, Büttner R, Harris CC, Yokota J, Thomas RK, Kohno T.
    • Journal Title

      Clin Cancer Res

      Volume: 23 Issue: 5 Pages: 1220-1226

    • DOI

      10.1158/1078-0432.ccr-16-1069

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Driver Gene Aberrations for Precision Medicine of Lung Adenocarcinoma.2016

    • Author(s)
      Saito M, Shiraishi K, Kunitoh H, Takenoshita S, Kohno T.
    • Journal Title

      Cancer Science

      Volume: 107 Issue: 6 Pages: 713-720

    • DOI

      10.1111/cas.12941

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Advances in targeted therapy and immunotherapyfor treatment of lung cancer.2016

    • Author(s)
      Saito M, Takenoshita S, Kohno T
    • Journal Title

      Ann. Cancer Res. Ther.

      Volume: 24 Pages: 1-6

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Multiplex Diagnosis of Oncogenic Fusion and MET Exon Skipping by Molecular Counting Using Formalin-Fixed Paraffin Embedded Lung Adenocarcinoma Tissues.2016

    • Author(s)
      Kuniko Sunami, Koh Furuta, Koji Tsuta, Shinji Sasada, Takehiro Izumo, Takashi Nakaoku, Yoko Shimada, Motonobu Saito, Hiroshi Nokihara, Shun-ichi Watanabe, Yuichiro Ohe, Takashi Kohno
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 11(2) Issue: 2 Pages: 203-12

    • DOI

      10.1016/j.jtho.2015.10.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma.2016

    • Author(s)
      Shiraishi K, Okada Y 他44名 Inazawa J 38番目
    • Journal Title

      Nat Commun.

      Volume: 7 Issue: 1 Pages: 12451-12451

    • DOI

      10.1038/ncomms12451

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of lung adenocarcinomas with exclusive dependence on oncogene fusions.2015

    • Author(s)
      Saito M, Shimada Y, Shiraishi K, Sakamoto H, Tsuta K, Totsuka H, Chiku S, Ichikawa H, Kato M, Watanabe S, Yoshida T, Yokota J, Kohno T
    • Journal Title

      Cancer Research

      Volume: 75 Pages: 2264-71

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Comparisons between mouse and human studies will help the prevention, diagnosis, and treatment of the deadliest type of lung cancer.2015

    • Author(s)
      Kohno T, Saito M.
    • Journal Title

      Journal of Thoracic Oncology

      Volume: 10 Issue: 4 Pages: 551-2

    • DOI

      10.1097/jto.0000000000000477

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Gene Aberrations for Precision Medicine against Lung Adenocarcinoma2017

    • Author(s)
      Saito M, Kono K, Kohno T
    • Organizer
      AACR Annual Meeting 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genomic focal amplification of PD-1 ligands in small cell lung cancer2017

    • Author(s)
      Saito M, Kono K, Kohno T
    • Organizer
      The 76th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Lung adenocarcinoma development with exclusive dependence on oncogene fusions2016

    • Author(s)
      Saito M, Takenoshita S, Yokota J, Kohno T
    • Organizer
      21st Congress of Asian Pacific Society of Respirology
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Lung adenocarcinoma development with exclusive dependence on oncogene fusions2016

    • Author(s)
      Saito M, Kono K, Kohno T
    • Organizer
      The 75th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ALK/RET/ROS1遺伝子融合陽性肺腺癌の遺伝子変異プロファイルとそのマウスモデルの検討2015

    • Author(s)
      齋藤元伸、白石航也、横田淳、竹之下誠一、河野隆志
    • Organizer
      第53回癌治療学会
    • Place of Presentation
      京都市
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Genomic focal amplification of the PD-L1 gene in small cell lung cancer2015

    • Author(s)
      齋藤元伸、白石航也、岩川麗香、竹之下誠一、横田淳、河野隆志
    • Organizer
      第74回日本癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] マイクロRNAを用いた肺腺がん術後再発に対するプラチナダブレット治療の効果予測2015

    • Author(s)
      齋藤元伸、白石航也、横田淳、Curtis C. Harris、竹之下誠一、河野隆志
    • Organizer
      第24回癌病態治療研究会
    • Place of Presentation
      栃木県日光市
    • Year and Date
      2015-06-25
    • Related Report
      2015 Research-status Report
  • [Book] 血液内科2017

    • Author(s)
      齋藤元伸、河野隆志
    • Total Pages
      130
    • Publisher
      化学評論社
    • Related Report
      2017 Annual Research Report
  • [Book] Medical Science Digest2016

    • Author(s)
      齋藤元伸、河野隆志
    • Total Pages
      100
    • Publisher
      北隆館
    • Related Report
      2016 Research-status Report
  • [Book] Annual Review 2016呼吸器2016

    • Author(s)
      齋藤元伸、河野隆志
    • Total Pages
      238
    • Publisher
      中外医学社
    • Related Report
      2016 Research-status Report
  • [Book] 次世代シークエンサー解析による新しい肺がん治療標的分子の発見. 呼吸器疾患診療の最先端呼吸器疾患診療の最先端2015

    • Author(s)
      齋藤元伸, 河野隆志
    • Total Pages
      502
    • Publisher
      先端医療技術研究所
    • Related Report
      2015 Research-status Report
  • [Remarks] 融合遺伝子を標的としたがん治療法の開発(ゲノム生物学研究分野)

    • URL

      http://www.nccri.ncc.go.jp/s010/010/010/20151209215834.html

    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2022-06-07  

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