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2017 Fiscal Year Final Research Report

Comprehensive analysis of lung adenocarcinoma focus on the recurrence and response to chemotherapy

Research Project

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Project/Area Number 15K10275
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionFukushima Medical University (2016-2017)
National Cancer Center Japan (2015)

Principal Investigator

Saito Motonobu  福島県立医科大学, 医学部, 講師 (90611749)

Project Period (FY) 2015-04-01 – 2018-03-31
Keywords肺腺癌 / ドライバー遺伝子 / 遺伝子融合
Outline of Final Research Achievements

We performed a comprehensive genetic analysis for lung adenocarcinomas (LADC) and found that the driver fusion cases showed a distinct profile with smaller numbers of nonsynonymous mutations in cancer-related genes or truncating mutations in SWI/SNF chromatin remodeling. On the other hand, pan-negative LADCs appear to develop from a large number of gene mutations, including mutations in TP53 and other cancer-related genes. Next, we have compared the frequency of each driver genes between Japan and US cohort. EGFR mutations are more prevalent in Japanese patients, whereas KRAS and BRAF mutations are more prevalent in the US. To date, the molecularly targeted drugs for KRAS mutations have not developed yet, targeted therapy have not adapted the patients with LADC in the US. In conclusion, the information of driver genes will aid in the selection of appropriate targeted therapy.

Free Research Field

ゲノム生物学

URL: 

Published: 2019-03-29  

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